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Topic Review
Physiology of the Endocannabinoid System
The endocannabinoid system (ECS) is involved in various processes, including brain plasticity, learning and memory, neuronal development, nociception, inflammation, appetite regulation, digestion, metabolism, energy balance, motility, and regulation of stress and emotions.
  • 1.3K
  • 10 Feb 2023
Topic Review
Racism
Racism is a deeply ingrained social phenomenon characterized by the systemic discrimination, prejudice, and unequal treatment of individuals or groups based on their racial or ethnic background. It manifests in various forms, including institutional practices, interpersonal biases, and structural inequalities, perpetuating disparities in access to opportunities, resources, and social privileges among different racial or ethnic communities. Understanding and addressing racism necessitate a comprehensive examination of historical legacies, societal structures, and individual attitudes to promote equity and justice.
  • 1.3K
  • 25 Jan 2024
Topic Review
Ultrasound for the Characterization of Renal Masses
Ultrasound is a widely available, approachable, and relatively inexpensive imaging modality that allows for real-time evaluation of a suspected renal mass without the drawbacks of ionizing radiation and the risk of an MRI. CEUS has several advantages over traditional grayscale ultrasound in the characterization of indeterminate renal masses. It has a distinct value in the characterization of cystic renal masses and has the potential to differentiate benign from malignant renal masses to some extent. Ultrasound molecular imaging could potentially be an extension of the use of CEUS for serial disease monitoring and longitudinal assessment of treatment response, though it remains in preclinical stages of development at this time. While emerging micro-Doppler techniques and elastography have shown some encouraging applications, current evidence is limited, and neither is ready for widespread clinical use.
  • 1.3K
  • 09 Mar 2022
Topic Review
Chromosome 7
Humans normally have 46 chromosomes in each cell, divided into 23 pairs. Two copies of chromosome 7, one copy inherited from each parent, form one of the pairs.
  • 1.3K
  • 24 Dec 2020
Topic Review
Inorganic Pyrophosphatase Activities Non-Radioactive Assays
Inorganic pyrophosphatase (PPase) is a ubiquitous enzyme that converts pyrophosphate (PPi) to phosphate and, in this way, controls numerous biosynthetic reactions that produce PPi as a byproduct. PPase activity is generally assayed by measuring the product of the hydrolysis reaction, phosphate. This reaction is reversible, allowing PPi synthesis measurements and making PPase an excellent model enzyme for the study of phosphoanhydride bond formation. 
  • 1.3K
  • 30 Apr 2021
Topic Review
Hyaluronic Acid-Based Scaffolds
There are HA-based scaffolds that can be used in wound healing as potential bioactive dressings such as bandages, topical gels, microspheres, nanoparticles, hydrocolloids, foams, transdermal/matrix patches, etc. Hussain et al. reported HA-functionalized nanoparticles for the co-delivery of resveratrol and curcumin for chronic diabetic wound treatment. 
  • 1.3K
  • 14 Jul 2021
Topic Review
VGs' impact on Pediatric Age
A growing number of children and adolescents play video games (VGs) for long amounts of time. The current outbreak of the Coronavirus pandemic has significantly reduced outdoor activities and direct interpersonal relationships. Therefore, a higher use of VGs can become the response to stress and fear of illness.
  • 1.3K
  • 26 Jul 2021
Topic Review
Human HtrA Family Proteases
The mammalian high temperature requirement A (HtrA) proteins are a family of evolutionarily conserved serine proteases, consisting of four homologs (HtrA1-4) that are involved in many cellular processes such as growth, unfolded protein stress response and programmed cell death. In humans, while HtrA1, 2 and 3 are widely expressed in multiple tissues with variable levels, HtrA4 expression is largely restricted to the placenta with the protein released into maternal circulation during pregnancy. This limited expression sets HtrA4 apart from the rest of the family. All four HtrAs are active proteases, and their specific cellular and physiological roles depend on tissue type. The dysregulation of HtrAs has been implicated in many human diseases such as cancer, arthritis, neurogenerative ailments and reproductive disorders.
  • 1.3K
  • 25 Oct 2021
Topic Review
Link of Mitochondrial Quality Control and Parkinson’s Disease
Dysfunctional mitochondrial quality control (MQC) is implicated in the pathogenesis of Parkinson’s disease (PD). The improper selection of mitochondria for mitophagy increases reactive oxygen species (ROS) levels and lowers ATP levels. The downstream effects include oxidative damage, failure to maintain proteostasis and ion gradients, and decreased NAD+ and NADPH levels, resulting in insufficient energy metabolism and neurotransmitter synthesis. A ketosis-based metabolic therapy that increases the levels of (R)-3-hydroxybutyrate (BHB) may reverse the dysfunctional MQC by partially replacing glucose as an energy source, by stimulating mitophagy, and by decreasing inflammation. Fasting can potentially raise cytoplasmic NADPH levels by increasing the mitochondrial export and cytoplasmic metabolism of ketone body-derived citrate that increases flux through isocitrate dehydrogenase 1 (IDH1). NADPH is an essential cofactor for nitric oxide synthase, and the nitric oxide synthesized can diffuse into the mitochondrial matrix and react with electron transport chain-synthesized superoxide to form peroxynitrite. Excessive superoxide and peroxynitrite production can cause the opening of the mitochondrial permeability transition pore (mPTP) to depolarize the mitochondria and activate PINK1-dependent mitophagy. Both fasting and exercise increase ketogenesis and increase the cellular NAD+/NADH ratio, both of which are beneficial for neuronal metabolism.
  • 1.3K
  • 31 Aug 2022
Topic Review
Foundation Fieldbus
Other than 4-20 mA analogue standard which is the most popular analogue standard in the field of industrial automation, smart transmitters based on wired digital communication protocols such as Foundation Fieldbus might be a good alternative to consider for the purpose of improved performance and increased reliability in measurement and control process. 
  • 1.3K
  • 13 Oct 2022
Topic Review
Technology Strategy
Technology strategy (information technology strategy or IT strategy) is the overall plan which consists of objectives, principles and tactics relating to use of technologies within a particular organization. Such strategies primarily focus on the technologies themselves and in some cases the people who directly manage those technologies. The strategy can be implied from the organization's behaviors towards technology decisions, and may be written down in a document. The strategy includes the formal vision that guide the acquisition, allocation, and management of IT resources so it can help fulfill the organizational objectives. Other generations of technology-related strategies primarily focus on: the efficiency of the company's spending on technology; how people, for example the organization's customers and employees, exploit technologies in ways that create value for the organization; on the full integration of technology-related decisions with the company's strategies and operating plans, such that no separate technology strategy exists other than the de facto strategic principle that the organization does not need or have a discrete 'technology strategy'. A technology strategy has traditionally been expressed in a document that explains how technology should be utilized as part of an organization's overall corporate strategy and each business strategy. In the case of IT, the strategy is usually formulated by a group of representatives from both the business and from IT. Often the Information Technology Strategy is led by an organization's Chief Technology Officer (CTO) or equivalent. Accountability varies for an organization's strategies for other classes of technology. Although many companies write an overall business plan each year, a technology strategy may cover developments somewhere between 3 and 5 years into the future. The United States identified the need to implement a technology strategy in order to restore the country's competitive edge. In 1983 Project Socrates, a US Defense Intelligence Agency program, was established to develop a national technology strategy policy.
  • 1.3K
  • 14 Oct 2022
Topic Review
Diabetic Macular Edema
Diabetic retinopathy (DR), with increasing incidence, is the major cause of vision loss and blindness worldwide in working-age adults. Diabetic macular edema (DME) remains the main cause of vision impairment in diabetic patients, with its pathogenesis still not completely elucidated. Vascular endothelial growth factor (VEGF) plays a pivotal role in the pathogenesis of DR and DME. 
  • 1.3K
  • 02 Nov 2022
Topic Review
Tropical Diseases Caused by Mosquitoes
Tropical diseases (TDs) are among the leading cause of mortality and fatality globally. The emergence and reemergence of TDs continue to challenge healthcare system. Several tropical diseases such as yellow fever, tuberculosis, cholera, Ebola, HIV, rotavirus, dengue, and malaria outbreaks have led to endemics and epidemics around the world, resulting in millions of deaths. The increase in climate change, migration and urbanization, overcrowding, and other factors continue to increase the spread of TDs.
  • 1.3K
  • 10 Nov 2022
Topic Review
Genetics of Impulsivity
In psychology, impulsivity (or impulsiveness) is a tendency to act on a whim, displaying behavior characterized by little or no forethought, reflection, or consideration of the consequences. Impulsive actions are typically "poorly conceived, prematurely expressed, unduly risky, or inappropriate to the situation that often result in undesirable consequences," which imperil long-term goals and strategies for success. Impulsivity can be classified as a multifactorial construct. A functional variety of impulsivity has also been suggested, which involves action without much forethought in appropriate situations that can and does result in desirable consequences. "When such actions have positive outcomes, they tend not to be seen as signs of impulsivity, but as indicators of boldness, quickness, spontaneity, courageousness, or unconventionality" Thus, the construct of impulsivity includes at least two independent components: first, acting without an appropriate amount of deliberation, which may or may not be functional; and second, choosing short-term gains over long-term ones. Impulsivity is both a facet of personality and a major component of various disorders, including ADHD, substance use disorders, bipolar disorder, antisocial personality disorder, and borderline personality disorder. Abnormal patterns of impulsivity have also been noted instances of acquired brain injury and neurodegenerative diseases. Neurobiological findings suggest that there are specific brain regions involved in impulsive behavior, although different brain networks may contribute to different manifestations of impulsivity, and that genetics may play a role. Many actions contain both impulsive and compulsive features, but impulsivity and compulsivity are functionally distinct. Impulsivity and compulsivity are interrelated in that each exhibits a tendency to act prematurely or without considered thought and often include negative outcomes. Compulsivity may be on a continuum with compulsivity on one end and impulsivity on the other, but research has been contradictory on this point. Compulsivity occurs in response to a perceived risk or threat, impulsivity occurs in response to a perceived immediate gain or benefit, and, whereas compulsivity involves repetitive actions, impulsivity involves unplanned reactions. Impulsivity is a common feature of the conditions of gambling and alcohol addiction. Research has shown that individuals with either of these addictions discount delayed money at higher rates than those without, and that the presence of gambling and alcohol abuse lead to additive effects on discounting.
  • 1.3K
  • 15 Nov 2022
Topic Review
Simultaneous Localisation and Mapping Techniques for Autonomous Vehicles
The advancements in Information and Communication Technology (ICT) as well as increasing demand for vehicular safety has led to significant progressions in Autonomous Vehicle (AV) technology. Perception and Localisation are major operations that determine the success of AV development and usage. Therefore, significant research has been carried out to provide AVs with the capabilities to not only sense and understand their surroundings efficiently, but also provide detailed information of the environment in the form of 3D maps. Visual Simultaneous Localisation and Mapping (V-SLAM) has been utilised to enable a vehicle understand its surroundings, map the environment, and identify its position within the area.
  • 1.3K
  • 22 Nov 2022
Topic Review
Hypouricemia and the Kidneys
Hypouricemia, defined as a serum uric acid level ≤ 2.0 mg/dL, can be produced by the renal wasting of uric acid. Considering normal values of the fractional excretion of uric acid (~10%), the essential role of the kidneys is closer to the conservation rather than elimination of uric acid. Thus, impaired uric-acid-transport function in the proximal tubule leads to hypouricemia. In many cases, hypouricemia can go unnoticed because it usually occurs without symptoms. Its clinical consequences need to be investigated.
  • 1.3K
  • 30 Nov 2022
Topic Review
Battery Thermal Management of Electric Vehicles
Lithium-ion batteries (LIBs), as energy storage devices, are considered to have a significant role in determining the performance of electric vehicles (EVs). LIBs depend vastly on temperature for facilitating an optimum performance and lifetime, with the commonly suggested operating temperature being in the range from 25 to 40 °C. Operation at lower or higher temperatures than the range can adversely affect or degrade the performance and lifetime of LIBs. Lower-temperature operation with a high current rate leads to lithium plating on the anode, capacity loss, impedance rises, ionic conductivity decreases, and internal short circuits due to metallic lithium dendrites. Meanwhile, higher-temperature operation could reduce the active materials and increase the internal resistance, even for overly high temperatures, potentially causing thermal runaways that might prompt fires and explosions.
  • 1.3K
  • 29 Dec 2022
Topic Review
Lipids in Macrophages of Different Tissue Location
Lipid metabolism is the major intracellular mechanism driving a variety of cellular functions such as energy storage, hormone regulation and cell division. Lipids, being a primary component of the cell membrane, play a pivotal role in the survival of macrophages. Lipids are crucial for a variety of macrophage functions including phagocytosis, energy balance and ageing. Lipid-loaded macrophages have recently been emerging as a hallmark for several diseases.
  • 1.3K
  • 12 Jan 2023
Topic Review
ProMatch: Semi-Supervised Learning with Prototype Consistency
Semi-supervised learning (SSL) methods have made significant advancements by combining consistency-regularization and pseudo-labeling in a joint learning paradigm. The core concept of these methods is to identify consistency targets (pseudo-labels) by selecting predicted distributions with high confidence from weakly augmented unlabeled samples. 
  • 1.3K
  • 04 Sep 2023
Topic Review
Decoding Sepsis-Induced Disseminated Intravascular Coagulation
Disseminated intravascular coagulation (DIC) is a pathological disease that often manifests as a complication in patients with sepsis. Sepsis is a systemic inflammatory response caused by infection and is a major public health concern worldwide.
  • 1.3K
  • 25 Sep 2023
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