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Topic Review
Exosome-Derived MicroRNAs of Human Milk
Multiple biologically active components of human milk support infant growth, health and development. Milk provides a wide spectrum of mammary epithelial cell-derived extracellular vesicles (MEVs) for the infant. Although the whole spectrum of MEVs appears to be of functional importance for the growing infant, the majority of recent studies report on the MEV subfraction of milk exosomes (MEX) and their miRNA cargo, which are in the focus of this entry.
  • 1.3K
  • 23 Jun 2021
Topic Review
Gluten Detection Methods
Celiac disease, wheat sensitivity, and allergy represent three different reactions, which may occur in genetically predisposed individuals on the ingestion of wheat and derived products with various manifestations. Improvements in the disease diagnostics and understanding of disease etiology unveiled that these disorders are widespread around the globe affecting about 7% of the population. The only known treatment so far is a life-long gluten-free diet, which is almost impossible to follow because of the contamination of allegedly “gluten-free” products. Accidental contamination of inherently gluten-free products could take place at any level from field to shelf because of the ubiquity of these proteins/grains. Gluten contamination of allegedly “gluten-free” products is a constant threat to celiac patients and a major health concern. Several detection procedures have been proposed to determine the level of contamination in products for celiac patients. 
  • 1.3K
  • 13 Jul 2021
Topic Review
Epithelial to Mesenchymal Transition
Pancreatic ductal adenocarcinoma (PDAC) is one of the malignancies with the worst prognosis despite a decade of efforts. The effectiveness of PDAC therapies is challenged by the early and widespread metastasis. Epithelial to mesenchymal transition (EMT) is a major driver of cancer progression and metastasis. 
  • 1.3K
  • 05 Aug 2021
Topic Review
SMYD3
The SMYD3 methyltransferase has been found overexpressed in several types of cancers of the gastrointestinal (GI) tract. While high levels of SMYD3 have been positively correlated with cancer progression in cellular and advanced mice models, suggesting it as a potential risk and prognosis factor, its activity seems dispensable for autonomous in vitro cancer cell proliferation. We first describe the oncogenic activity of SMYD3 as a transcriptional activator of genes involved in tumorigenesis, cancer development and transformation and as a co-regulator of key cancer-related pathways. Then, we dissect its role in orchestrating cell cycle regulation and DNA damage response (DDR) to genotoxic stress by promoting homologous recombination (HR) repair, thereby sustaining cancer cell genomic stability and tumor progression. Based on this evidence and on the involvement of PARP1 in other DDR mechanisms, we also outline a synthetic lethality approach consisting of the combined use of SMYD3 and PARP inhibitors, which recently showed promising therapeutic potential in HR-proficient GI tumors expressing high levels of SMYD3. Overall, these findings identify SMYD3 as a promising target for drug discovery.
  • 1.3K
  • 14 Sep 2021
Topic Review
Intracellular Sensors——Nod-like Receptors
NOD-like receptors are functionally diverse intracellular sensors with heterogeneous signaling pathways. With the exception of NLRP10, which lacks an Leucine-rich repeats (LRR) domain, all the containing receptors (NLR) families share a common nucleotide-binding and oligomerization (NACHT) and LRR domain organization.
  • 1.3K
  • 03 Nov 2021
Topic Review
Main Characteristics of CircRNAs
Circular RNAs (circRNAs) represent a category of non-coding RNAs (ncRNAs) and constitute functional RNAs that are predetermined not to be translated, but transcribed. CircRNAs are characterized by single-stranded closed-loop structures without 5′-3′-polarity or a polyadenylated tail. The term “circRNA” was first used by Sanger et al. when identifying the structure of viroids.
  • 1.3K
  • 06 Jan 2022
Topic Review
Integrated Multi-Omics
Advancements in high-throughput technology provide new opportunities for omics research to understand the pathological process of various complex human diseases. The integration of multi-omics technologies can systematically reveal the interactions among aging molecules from a multidimensional perspective.
  • 1.3K
  • 07 Jan 2022
Topic Review
Wearable Sensors and Machine Learning for Hypovolemia Problems
Hypovolemia is a physiological state of reduced blood volume that can exist as either (1) absolute hypovolemia because of a lower circulating blood (plasma) volume for a given vascular space (dehydration, hemorrhage) or (2) relative hypovolemia resulting from an expanded vascular space (vasodilation) for a given circulating blood volume (e.g., heat stress, hypoxia, sepsis). The external environment and the user's level of physical activity can exacerbate hypovolemic challenges to the body. Noninvasive, wearable sensing systems are being developed to track a user's ability to compensate for these challenges. 
  • 1.3K
  • 13 Jan 2022
Topic Review
Non-Equilibrium Thermodynamics and Psychology in Biological Aging
In humans, biological aging (age-associated degrading changes), widely observed in molecular and cellular processes, underly the time-dependent decline in spatial navigation, time perception, cognitive and psychological abilities, and memory. Cross-talk of biological, cognitive, and psychological clocks provides an integrative contribution to healthy and advanced aging. At the molecular level, genome, proteome, and lipidome instability are widely recognized as the primary causal factors in aging. Through stress response systems (SRS), the environmental and psychological stressors contribute to the age-associated “collapse” of protein homochirality. The role of prevalent protein chirality and entropy of protein folding in biological aging is mainly overlooked. In a more generalized context, the time-dependent shift from enzymatic to the nonenzymatic transformation of biochirality might represent an important and yet underappreciated hallmark of aging. We provide the experimental arguments in support of the racemization theory of aging.
  • 1.3K
  • 17 Jan 2022
Topic Review
Anisakiasis
Anisakiasis is a zoonosis caused by the ingestion of raw or undercooked seafood infected with third-stage larvae (L3) of the marine nematode Anisakis. Based on L3 localization in human accidental hosts, gastric, intestinal or ectopic (extra-gastrointestinal) anisakiasis can occur, in association with mild to severe symptoms of gastrointestinal and/or allergic nature.
  • 1.3K
  • 20 Apr 2022
Topic Review
World-Wide Data of Organochlorine Pesticide in Agricultural Soils
Soil constitutes the central environmental compartment that, primarily due to anthropogenic activities, is the recipient of several contaminants. Among these are organochlorine pesticides (OCPs), which are of major concern, even though they were banned decades ago due to their persistence and the health effects they can elicit. Soil pollution by OCPs should be an essential aspect of the characterization of whole soil quality, considering that a significant percent of soils on a global scale are in the borderline of suitability for cultivation and pertinent activities. The latter, to an extent, is attributed to the presence of organic contaminants, especially those of persistent chemical natures.
  • 1.3K
  • 30 May 2022
Topic Review
O-GlcNAcylation Regulate Skeletal Muscle
O-GlcNAcylation is a highly dynamic, reversible and atypical glycosylation that regulates the activity, biological function, stability, sublocation and interaction of target proteins. O-GlcNAcylation receives and coordinates different signal inputs as an intracellular integrator similar to the nutrient sensor and stress receptor, which target multiple substrates with spatio-temporal analysis specifically to maintain cellular homeostasis and normal physiological functions.
  • 1.3K
  • 13 Jun 2022
Topic Review
Oxidative Pathways in the Pathogenesis of PD
Parkinson’s disease (PD) is a progressive neurodegenerative disorder that arises due to a complex and variable interplay between elements including age, genetic, and environmental risk factors that manifest as the loss of dopaminergic neurons. Contemporary treatments for PD do not prevent or reverse the extent of neurodegeneration that is characteristic of this disorder and accordingly, there is a strong need to develop new approaches which address the underlying disease process and provide benefit to patients with this debilitating disorder. Mitochondrial dysfunction, oxidative damage, and inflammation have been implicated as pathophysiological mechanisms underlying the selective loss of dopaminergic neurons seen in PD.
  • 1.3K
  • 05 Jul 2022
Topic Review Peer Reviewed
Evolutionary Perspective on Improving Mental Health
Mental issues are by many considered the main challenge for health authorities in industrialized nations. In this entry, I discuss an approach that may prove useful for ameliorating the situation and thereby improving quality of life. The analysis uses an understanding of the brain based on evolution and neurobiology, so consequently the ideas presented differ somewhat from traditional psychological thinking. Briefly, it appears likely that the problems with psychopathology are partly due to a lifestyle at odds with human nature. The key for finding preventive measures then is to identify the contributing mismatches. Based on the present perspective, therapeutic interventions can be construed as altering the brain by exercising functions that ought to be strengthened. By understanding brain plasticity, and the functions that are likely to need improvement in relation to mental health, we stand a better chance at devising interventions that work. 
  • 1.3K
  • 26 Aug 2022
Topic Review
2008–2009 Kenya Drought
Template:Infobox famine Between 2008 and early 2010, Kenya, one of the countries of Eastern Africa, was affected by a severe drought, which put ten million people at risk of hunger and caused a large number of deaths to livestock in Kenyan Arid and Semi-Arid Lands (ASALs), constituting around 88% of the country. The areas which experienced the worst effects were Northern Kenya, Somalia and Southern Ethiopia, most severely in Kajiado and Laikipia. These predominantly pastoral regions reported deaths of up to half of the livestock. Droughts in Kenya have become more frequent causing crop failures and devastation as three-quarters of the population are sustained by agriculture.
  • 1.3K
  • 17 Oct 2022
Topic Review
Court of Auditors (Spain)
The Tribunal de Cuentas (Court of Auditors) is the supreme governmental accounting body of Spain responsible of the comptrolling of the public accounts and the auditing of the accountancy of the political parties, in accordance with the Constitution and its Organic Law. The Court of Auditors is composed by the President and 12 counsellors. The Counsellors are appointed by the Cortes Generales, six of them by the Congress and the other six by the Senate. To be appointed Counsellor of the Court it is needed to be a person with knowledge in audit, judge, prosecutor, university teacher or a public servant in an office that requieres superior studies, lawyer, economist or trade profesor, all of them with recognized experience and with fifteen years of professional activity. The Court Account Counselors are independent and irremovable. Their term is 9 years.
  • 1.3K
  • 21 Nov 2022
Topic Review
Machine Learning in Molecular Design for Fragrance Molecules
The demand for new novel flavour and fragrance (F&F) molecules has boosted the need for a systematic approach to designing fragrance molecules. However, the F&F-related industry still relies heavily on experimental approaches or on existing databases without considering the consequences resulting from changes in concentration, which could omit potential fragrances. Computer-aided molecular design (CAMD) has great potential to identify novel molecular structures to be used as fragrances. 
  • 1.3K
  • 30 Dec 2022
Topic Review
Treatment of Posthemorrhagic Ventricular Dilatation
Volpe IV is defined as intraventricular hemorrhage combined with venous infarction) and probably lead to posthemorrhagic ventricular dilatation (PHVD). Severe IVH and subsequent PHVD have become the leading causes of brain injury and neurodevelopmental dysplasia in preterm infants. Researchers reviewed the literature on the diagnosis and therapeutic strategies for PHVD and provide some recommendations for management to improve the neurological outcomes.
  • 1.3K
  • 03 Feb 2023
Topic Review
Electric Vehicle Charging Infrastructure in EU
Fast charging points are located within the public charging infrastructure, mainly along highways. In many regions the fast charging infrastructure for electric cars is still insufficiently developed. Due to the great economic diversity of EU countries, the development of charging infrastructure proceeds at different paces. For this reason, it is important to ensure that fast charging points are located primarily along the Trans-European Network (TEN-T) network and highways.
  • 1.3K
  • 30 Jan 2023
Topic Review
Physiology of the Endocannabinoid System
The endocannabinoid system (ECS) is involved in various processes, including brain plasticity, learning and memory, neuronal development, nociception, inflammation, appetite regulation, digestion, metabolism, energy balance, motility, and regulation of stress and emotions.
  • 1.3K
  • 10 Feb 2023
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