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Topic Review
Hydrotropism
Hydrotropism is the movement or growth of a plant towards water. It is a type of tropism, or directional growth response, that is triggered by water. Plants are able to detect water through various stimuli, including changes in moisture levels and changes in water potential. 
  • 1.3K
  • 23 Feb 2023
Topic Review
Nutriepigenomics in Environmental-Associated Oxidative Stress
Complex molecular mechanisms define our responses to environmental stimuli. Beyond the DNA sequence itself, epigenetic machinery orchestrates changes in gene expression induced by diet, physical activity, stress and pollution, among others. Importantly, nutrition has a strong impact on epigenetic players and, consequently, sustains a promising role in the regulation of cellular responses such as oxidative stress. As oxidative stress is a natural physiological process where the presence of reactive oxygen-derived species and nitrogen-derived species overcomes the uptake strategy of antioxidant defenses, it plays an essential role in epigenetic changes induced by environmental pollutants and culminates in signaling the disruption of redox control. 
  • 1.3K
  • 18 Apr 2023
Topic Review
Tracing the Timber Supply Chain
Traceability is the ability to follow the processes that a raw material or product goes through. For forestry, this means identifying the wood from the standing tree to the mill entrance and recording all information about the technical (production) and spatial (transportation) manipulation of the timber by linking it to the ID.
  • 1.3K
  • 11 Sep 2023
Topic Review
Direct Laser Deposition of Inconel 625
The direct laser deposition (DLD) process has seen rigorous research in the past two decades due to its ability to directly manufacture products followed by minimal machining. The process input variables play a vital role in determining the properties achieved in the products manufactured by the DLD method. Inconel 625, a nickel-based superalloy with exceptional mechanical performance and corrosion resistance, has been used in critical applications within the aerospace, process, and marine industry.
  • 1.3K
  • 11 May 2023
Topic Review
The Single Toxin Origin of Alzheimer’s Disease
New data suggest that the aggregation of misfolded native proteins initiates and drives the pathogenic cascade that leads to Alzheimer’s disease (AD) and other age-related neurodegenerative disorders. Researchers propose a unifying single toxin theory of brain neurodegeneration that identifies new targets and approaches to the development of disease-modifying treatments. An extensive body of genetic evidence suggests soluble aggregates of beta-amyloid (Aβ) as the primary neurotoxin in the pathogenesis of AD. New insights from fluid biomarkers, imaging, and clinical studies provide further evidence for the decisive impact of toxic Aβ species in the initiation and progression of AD.
  • 1.3K
  • 21 Mar 2024
Topic Review
Loop Mediated Isothermal Amplification
The recent progress of molecular diagnostics has allowed the generation of different sophisticated tools, like loop-mediated isothermal amplification (LAMP). This technique has become a well-established in different fields, including medicine, agriculture, and food industry, due to its high specificity, analytical sensitivity, technical simplicity, short analysis time, and low cost. LAMP involves isothermal amplification of target DNA and is highly accordant with point-of-care analysis. It has great potential to improve plant protection diagnostics, especially for in field analyses, detection of plant quarantine pathogens or virus pathogens in early infection stages. In this review, the authors provide detailed overview of the LAMP, describing in particular evolution of the technique, design and main features of the primer set, different visualization methods of LAMP results, its evolution and use in different fields, reporting in detail LAMP application in plant virology, and the main advantages of this technique.
  • 1.3K
  • 28 Oct 2020
Topic Review
Dendritic Cell Extracellular Vesicles
Dendritic cells have a central role in starting and regulating immune functions in anticancer responses. The crosstalk of dendritic cells with tumors and other immune cell subsets is partly mediated by extracellular vesicles (EVs) secreted by both cell types and is multidirectional. In the case of dendritic cell EVs, the presence of stimulatory molecules and their ability to promote tumor antigen-specific responses, have raised interest in their uses as therapeutics vehicles.
  • 1.3K
  • 17 Dec 2020
Topic Review
Voltage Gated Ion Channels
Safety Pharmacology is one of the most dynamically developing disciplines, whose objective is to assess the potential risks of improperly conducted pharmacotherapy. Evaluation of a potential risks in the use of a given substance is vital for placing a new medicine on the market. The Organisation for Economic Co-operation and Development (OECD) has issued a number of guidelines for drug safety testing [1, 2]. However, the continuous development of medicine demands the extension and refinement of the test panel that a new molecule must undergo before it can be released for use by patients. Toxic effects of compounds on the most important organs are among the most frequent reasons of elimination of substances from further tests. Additionally, safety tests are also performed for medicines already approved for use. Such trials are required, e.g., to register new indications for "old" drugs.  The above mentioned activities require a suitable identifications of the antitargets which are commonly defined as undesirable molecular targets that play an essential role in the proper functioning of cells. Down modulation of an antitarget results in clinically unacceptable side effects, initiation of disease, or deleterious alterations in disease progression. This results in shorter onset time of the disease, increased disease burden, poorer patient outcome, or decreased survival time.
  • 1.3K
  • 27 Jan 2021
Topic Review
Toxic Wasting Disorders in Sheep
Infectious and parasitic agents have been frequently associated with debilitating and wasting conditions in sheep. The prevalence of these agents has probably undermined the role of toxic causes as contributors to such disorders. In addition, many of these intoxications frequently produce acute clinical disease with specific and characteristic lesions, thus a causal relationship with the toxic substance may be relatively easy to establish. However, persistent exposure to some of these organic or inorganic toxic substances may lead to emaciation, ill-thrift, and poor external aspect. The anti-nutritional factors and alkaloids of several plants, including pyrrolizidine alkaloids, among others, have also been associated with emaciation and/or poor general performance in sheep flocks.
  • 1.3K
  • 09 Feb 2021
Topic Review
Acute Promyelocytic Leukemia in Children
Acute promyelocytic leukemia (APL) represents a paradigm of precision medicine.
  • 1.3K
  • 07 May 2021
Topic Review
Inflammation in TGFβ-Dependent EMT
Epithelial–mesenchymal transition (EMT) is a complex cellular program known to be a crucial driver in the context of embryonic development, wound healing and tumour progression.
  • 1.3K
  • 03 Mar 2021
Topic Review
Geochemical Characteristics of Oceanic Carbonatites
The occurrence of carbonatites in oceanic settings is very rare if compared with their continental counterpart, having been reported only in Cape Verde and Canary Islands. This entry provides an overview of the main geochemical characteristics of oceanic carbonatites, around which many debates still exist regarding their petrogenesis.
  • 1.3K
  • 26 Mar 2021
Topic Review
Vitamin K2 in “Bone-Vascular Crosstalk”
Osteoporosis (OP) and vascular calcification (VC) represent relevant health problems that frequently coexist in the elderly population. Traditionally, they have been considered independent processes, and mainly age-related. However, an increasing number of studies have reported their possible direct correlation, commonly defined as “bone-vascular crosstalk”. Vitamin K2 (VitK2), a family of several natural isoforms also known as menaquinones (MK), has recently received particular attention for its role in maintaining calcium homeostasis.
  • 1.3K
  • 14 Apr 2021
Topic Review
Liver Surgery
Major high-risk surgery (HRS) exposes patients to potential perioperative adverse events. Hepatic resection of colorectal metastases can surely be included into the HRS class of operations. Limiting such risks is the main target of the perioperative medicine.
  • 1.3K
  • 24 May 2021
Topic Review
Propofol Sedation
Propofol is a commonly used intravenous sedative for ventilator-dependent patients. Its advantage over other sedative agents, such as benzodiazepines, is in its rapid onset and short half-life which allows for daily awakening and spontaneous breathing trials. The use of propofol is recommended by the Brain Trauma Foundation for the treatment of elevated intracranial pressure and sometimes prolonged continuous large doses are required.
  • 1.3K
  • 07 Jul 2021
Topic Review
FHL2
Four and a half LIM domains 2 (FHL2) was originally described as ‘Down-regulated in Rhabdomyosarcoma LIM protein’ (DRAL) and is composed of LIM domains that are named after their initial discovery in the proteins Lin11, Isl-1 and Mec-3. FHL2 consists of four and a half LIM domains, each composed of two zinc fingers, except the first ‘half’ LIM-domain which has only one. While the structure of the four and a half LIM domains had been uncovered previously using Nuclear Magnetic Resonance (NMR) spectroscopy, the complete FHL2 protein structure is unknown; however, it has recently been predicted using the protein structure neural network AlphaFold.
  • 1.3K
  • 19 Oct 2021
Topic Review
Bamboo Bambusa tulda Roxb
Bamboos belong to the monocotyledonous plant family Poaceae and subfamily Bambusoideae. They are globally distributed from 51° North to 47° South except in the polar regions. There are ~125 genera and 1670 species of bamboos identified so far. Compared to other grasses, flowering in bamboo is quite divergent, yet complex with respect to time to flower, number of individual culms in a population that have been induced at a time (sporadic vs. gregarious), nature of monocarpy, morphology of inflorescences (solitary spikelet vs. pseudospikelet), biology of pollen and nature of genetic compatibility. Wide diversity exists even across species and genotypes. However, due to the rarity of flowering and inaccessibility, few studies have been done to systematically analyse diverse aspects of the reproductive behaviour of bamboo.
  • 1.3K
  • 11 Nov 2021
Topic Review
Integration of Environmental Justice and Sustainability in Practice
The environmental justice (EJ) movement has been a key factor in the United States’ struggle to provide a healthy environment for all to thrive. The origins of the movement date as far back as the 1960’s, led primarily by people of color and low economic status communities living in America’s most polluted environments. More recently, the just sustainability movement calls for the inclusion of EJ considerations, including social justice, equity, and human rights, into sustainability science and initiatives.
  • 1.3K
  • 13 Jan 2022
Topic Review
Dairy Sheep Milk Genes
The dairy sheep industry is an important but lacking part of the small ruminant industry. For a sheep breeding program, in addition to wool and meat use, sheep milk can also be processed into high-end dairy products such as cheese and milk powder and bring high economic interests for businesses home and abroad. The nutritional value of sheep milk is found higher than that of goat milk and cow milk, with abundant fat yield, protein percentage, and mineral contents, which provide a good opportunity for the development of the sheep milk industry. 
  • 1.3K
  • 28 Feb 2022
Topic Review
Current Advanced on Raman Spectroscopy
Nowadys, Raman spectroscopy (RS) has been used in several studies on animal cells. Also, the method is popular among biophysicists and life science researchers. RS allows for the study of living cells in their natural conditions without any damage. RS is a well-known approach used in many of biomedical studies. Since biomolecules are involved, the main obstacle to the use of such methods in life science research is the low signal of Raman scattering. There are a number of modifications of RS that allow Raman scattering to be improved. There are existing approaches to detect Raman signals not only on the surface of human skin, but also inside the vasculature and various organs of patients.
  • 1.3K
  • 23 Apr 2022
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