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Topic Review
Hypothyroidism-Associated Dyslipidemia and NAFLD
Thyroid hormones control lipid metabolism by exhibiting specific effects on the liver and adipose tissue in a coordinated manner. Different diseases of the thyroid gland can result in hypothyroidism. Hypothyroidism is frequently associated with dyslipidemia. Hypothyroidism-associated dyslipidemia subsequently results in intrahepatic accumulation of fat, leading to nonalcoholic fatty liver disease (NAFLD), which leads to the development of hepatic insulin resistance. 
  • 1.3K
  • 07 Dec 2021
Topic Review
Fatigue Life Prediction of BGA Solder Joints
Ball grid array (BGA) packaging is a new type of surface mount multi-terminal packaging technology. BGA packaging is widely used in the field of microelectronic manufacturing industries due to its multiple I/O volumes and excellent electric characteristics. However, due to environmental loads such as vibration and impact during its production and application, defects inevitably emerge in BGA solder joint defects, which will lead to the failure of electronic products. 
  • 1.3K
  • 28 Feb 2022
Topic Review
Oxidative Stress Related to Plasmalemmal/Mitochondrial Phosphate Transporters
Inorganic phosphate (Pi) is essential for maintaining cellular function but excess of Pi leads to serious complications, including vascular calcification. Accumulating evidence suggests that oxidative stress contributes to the pathogenic progression of calcific changes. However, the molecular mechanism underlying Pi-induced reactive oxygen species (ROS) generation and its detrimental consequences remain unclear. Type III Na+-dependent Pi cotransporter, PiT-1/-2, play a significant role in Pi uptake of vascular smooth muscle cells. Pi influx via PiT-1/-2 increases the abundance of PiT-1/-2 and depolarization-activated Ca2+ entry due to its electrogenic properties, which may lead to Ca2+ and Pi overload and oxidative stress. At least four mitochondrial Pi transporters are suggested, among which the phosphate carrier (PiC) is known to be mainly involved in mitochondrial Pi uptake. Pi transport via PiC may induce hyperpolarization and superoxide generation, which may lead to mitochondrial dysfunction and endoplasmic reticulum stress, together with generation of cytosolic ROS. Increase in net influx of Ca2+ and Pi and their accumulation in the cytosol and mitochondrial matrix synergistically increases oxidative stress and osteogenic differentiation, which could be prevented by suppressing either Ca2+ or Pi overload. Therapeutic strategies targeting plasmalemmal and mitochondrial Pi transports can protect against Pi-induced oxidative stress and vascular calcification. 
  • 1.3K
  • 25 Mar 2022
Topic Review
A New Perspective on Perceived Overqualification
A new perspective on perceived overqualification:This article contains five variables, perceived overqualification, innovative behavior, felt trust, ability face pressure and length of service. Perceived overqualifications refer to the level of knowledge, skills, experience, and ability that an individual possesses that exceeds the requirements of the current job, which is a situation of underemployment. Employee innovative behavior refers to the new ideas, new products, new services, or new methods that employees generate in their work that are meaningful to the enterprise. Felt trust refers to the perception of one party’s willingness to take risks for the actions of another party. Ability face pressure, also known as “perceived face threat based on ability,” is a result of the perceived possibility and potential risk of losing face due to the individual’s desire for others to recognize their own abilities, achievements, and status. Length of service is the length of time an employee has worked since entering an organization, where the length of service can have an important impact on employees’ perceptions, self-evaluations, attitudes, and even behaviors. In studying the relationship between perceived overqualification and innovation behavior, this entry introduces new perspectives and variables, felt trust, ability face pressure, and length of service to conduct research, and has made some findings, as detailed in the entry.
  • 1.3K
  • 08 Apr 2022
Topic Review
Being Nonreligious in Croatia
Catholicism in the Croatian context has been one of the most powerful sources of collective belonging for centuries. Since the fall of socialism, desecularization tendencies have manifested as homogenization, collectivization, and deprivatization of religion. (Non)religiosity became a contested issue, which not only implied belonging (ethnic, national, historical) but was also highly politicized.
  • 1.3K
  • 12 May 2022
Topic Review
Work-Related Stress during Home-Based Remote Work
Remote work takes place outside a designated work location, such as corporate offices, and is often associated with working from home or working (home-based remote work) at a client’s location. In contrast, telework can be conducted remotely as well, but also focuses on the use of personal electronical devices . Ideally, job demands and job resources behave in a dynamic, balanced manner that lead to or maintain employee health. However, when work demands exceed work resources and work resources are inadequate for work demands, an imbalance occurs that leads to WRS over time.
  • 1.3K
  • 31 May 2022
Topic Review
Fault Detection and Classification of Wind Turbines
Wind turbines are widely used worldwide to generate clean, renewable energy. The biggest issue with a wind turbine is reducing failures and downtime, which lowers costs associated with operations and maintenance. Wind turbines’ consistency and timely maintenance can enhance their performance and dependability.
  • 1.3K
  • 27 Sep 2022
Topic Review
Charge
In physics, a charge is any of many different quantities, such as the electric charge in electromagnetism or the color charge in quantum chromodynamics. Charges correspond to the time-invariant generators of a symmetry group, and specifically, to the generators that commute with the Hamiltonian. Charges are often denoted by the letter Q, and so the invariance of the charge corresponds to the vanishing commutator [math]\displaystyle{ [Q,H]=0 }[/math], where H is the Hamiltonian. Thus, charges are associated with conserved quantum numbers; these are the eigenvalues q of the generator Q.
  • 1.3K
  • 14 Oct 2022
Topic Review
Social Security
Social security is "any government system that provides monetary assistance to people with an inadequate or no income". In the United States, this is usually called welfare or a social safety net, especially when talking about Canada and European countries. Social security is asserted in Article 22 of the Universal Declaration of Human Rights, which states: In simple terms, the signatories agree that the society in which a person lives should help them to develop and to make the most of all the advantages (culture, work, social welfare) which are offered to them in the country. Social security may also refer to the action programs of an organization intended to promote the welfare of the population through assistance measures guaranteeing access to sufficient resources for food and shelter and to promote health and well-being for the population at large and potentially vulnerable segments such as children, the elderly, the sick and the unemployed. Services providing social security are often called social services. Terminology in this area is somewhat different in the United States from in the rest of the English-speaking world. The general term for an action program in support of the well being of poor people in the United States is welfare program, and the general term for all such programs is simply welfare. In American society, the term welfare arguably has negative connotations. In the United States, the term Social Security refers to the US social insurance program for all retired and disabled people. Elsewhere the term is used in a much broader sense, referring to the economic security society offers when people are faced with certain risks. In its 1952 Social Security (Minimum Standards) Convention (nr. 102), the International Labour Organization (ILO) defined the traditional contingencies covered by social security as including: People who cannot reach a guaranteed social minimum for other reasons may be eligible for social assistance (or welfare, in American English). Modern authors often consider the ILO approach too narrow. In their view, social security is not limited to the provision of cash transfers, but also aims at security of work, health, and social participation; and new social risks (single parenthood, the reconciliation of work and family life) should be included in the list as well. Social security may refer to: A report published by the ILO in 2014 estimated that only 27% of the world's population has access to comprehensive social security.
  • 1.3K
  • 04 Nov 2022
Topic Review
Bertielliasis
Bertielliasis is the infection of Bertiella, a cestode tapeworm parasite that primarily infects nonhuman primates, rodents and Australia n marsupials. Occasionally, human infections have been documented by one of two species: Bertiella studeri, or Bertiella mucronata. Of 29 different Bertiella species, only these two can infect humans. These infections present with symptoms similar to most tapeworm cases, and are frequently misdiagnosed. Bertiella transmission is through oribatid mites that are often present in the soil of problem areas, and can be easily prevented by avoiding contact with nonhuman primates, rodents and soil in these areas.
  • 1.3K
  • 14 Nov 2022
Topic Review
New Pedestrianism
New Pedestrianism (NP) is a more pedestrian and ecology-oriented variation of New Urbanism in urban planning theory, founded in 1999 by Michael E. Arth, an American artist, urban/home/landscape designer, futurist, and author. NP addresses the problems associated with New Urbanism and is an attempt to solve various social, health, energy, economic, aesthetic, and environmental problems, with special focus on reducing the role of the automobile.A neighborhood or new town utilizing NP is called a Pedestrian Village. Pedestrian Villages can range from being nearly car-free to having automobile access behind nearly every house and business, but pedestrian lanes are always in front. To a large extent New Urbanism is a revival of traditional street patterns and urban design. New Pedestrianism also respects traditional town design, but seeks to further reduce the negative impact of the automobile, the use of which has increased dramatically since WWII. By eliminating the front street and replacing it with a tree-lined pedestrian lane, emphasis is placed on low-impact alternative travel such as walking and cycling. Pedestrian lanes are usually 12 to 15 feet (5 m) wide, with one smooth side for rolling conveyances such as bicycles, Segways, and skates and the other, narrower, textured side for pedestrians and wheelchairs. Eliminating the automobile street from the front allows for intimate scale plazas, fountains, pocket parks, as well as an unspoiled connection to natural features such as lakes, streams, and forests that may border or be included in a Pedestrian Village. A vast public realm is created that is free from the sight, smell, and sound of automobiles, yet automobiles are still served on a separate network. New Pedestrianism has been proposed for Kisima Kaya, a new town in Kenya, for Tiger Bay Village, FL as a solution to the homeless problem, and for new towns and neighborhoods that can be built anywhere whether as rehabilitation of existing neighborhoods, infill, edge-of-town neighborhoods, or new towns.
  • 1.3K
  • 15 Nov 2022
Topic Review
Multi-Anvil Press
The multi-anvil press is a type of device designed to produce extremely high pressures in a relatively small volume. This type of anvil press is used in materials science and geology for the synthesis and study of solid phase materials under extreme pressure, as well as for the industrial production of valuable minerals, especially synthetic diamonds. These instruments allow the simultaneous compression and heating of millimeter size solid phase samples such as rocks, minerals, ceramics, glasses, composite materials, or metal alloys and are capable of reaching pressures above 25 GPa and temperatures exceeding 2500 °C. This allows mineral physicists and petrologists studying the Earth’s interior to experimentally reproduce the conditions found throughout the lithosphere and upper mantle, to a depth of 700 km (citation, figure 1,2). Diamond anvil cells and light-gas guns can access even higher pressures, but the multi-anvil apparatus can accommodate much larger samples, which simplifies sample preparation and improves the precision of measurements and the stability of the experimental parameters (citation needed).
  • 1.3K
  • 17 Nov 2022
Topic Review
Action of Eugenol in Cancer
The last decade has seen a breakthrough in the investigations related to the anticancer potential of dietary phytoconstituents. Interestingly, a handsome number of bioactive principles, ranging from phenolic acids, phenylpropanoids, flavonoids, stilbenes, and terpenoids to organosulphur compounds have been screened for their anticancer properties. Among the phenylpropanoids currently under clinical studies for anticancer activity, eugenol is a promising candidate. Eugenol is effective against cancers like breast, cervical, lung, prostate, melanomas, leukemias, osteosarcomas, gliomas, etc., as evident from preclinical investigations.
  • 1.3K
  • 18 Nov 2022
Topic Review
Sustainable Valorisation of Agri-Food Wastes
In the upcoming years, the world will face societal challenges arising, in particular, from the impact of climate change and the inefficient use of natural resources, in addition to an exponential growth of the world population, which according to the United Nations (UN) estimations will be 9.8 billion in 2050. This increasing trend requires optimized management of natural resources with the use of value-added waste and a significant reduction in food loss and food waste. Moreover, the recent pandemic situation, COVID-19, has contributed indisputably. Along with the agri-food supply chain, several amounts of waste or by-products are generated.
  • 1.3K
  • 28 Dec 2022
Topic Review
Cap-Independent Circular mRNA Translation
The mRNA platform has become the method of choice in vaccine development to find new ways to fight infectious diseases.  This instability is due to the fact that the five-prime and three-prime ends of the mRNA are a substrate for the ubiquitous exoribonucleases. To address the problem, circular mRNAs have been proposed for transgene delivery as they lack these ends. Notably, circular RNAs do not have a capped five-prime end, which makes it impossible to initiate translation canonically.
  • 1.3K
  • 13 Feb 2023
Topic Review
Multitrophic Interactions of Entomopathogenic Fungi, Crops, and Insects
Multitrophic interactions link several trophic levels, including plants, phytophagous, predators, parasitoids, and/or pathogens.
  • 1.3K
  • 21 Feb 2023
Topic Review
Different Types of Solar Cells
Solar energy is free from noise and environmental pollution. It could be used to replace non-renewable sources such as fossil fuels, which are in limited supply and have negative environmental impacts. The first generation of solar cells was made from crystalline silicon. They were relatively efficient, however very expensive because they require a lot of energy to purify the silicon. The production of solar cells has been improved since the first generation (thin-film solar cells, dye-sensitized solar cells, perovskite solar cells, and organic solar cells).
  • 1.3K
  • 08 May 2023
Topic Review
Molecular Dynamics Simulations for DNAs
DNA carries the genetic information required for the synthesis of RNA and proteins and plays an important role in many processes of biological development. Understanding the three-dimensional (3D) structures and dynamics of DNA is crucial for understanding their biological functions and guiding the development of novel materials. Molecular dynamics (MD) simulations can generally reproduce the behavior of DNAs in a computer, providing detailed structural and dynamical insights that enhancing our comprehension of relevant experimental data. MD simulations using classical force fields such as AMBER and CHARMM have provided highly detailed and flexible descriptions of DNA dynamics, including structural transformations, stability of non-canonical conformations, salt ion cohesion effects, twist-stretch coupling of stress, flexibility under methylation modifications, and interactions with other macromolecules. It is always fascinating to obtain microscopic insights into DNA dynamics through MD simulations. However, the innumerable degrees of freedom, interconnected in complex ways, can make it practically impossible to detect DNA dynamics on biologically relevant time scales and length scales using currently available computer hardware
  • 1.3K
  • 28 Jun 2023
Topic Review
Digital Twins
Digital Twins, which are virtual representations of physical systems mirroring their behavior, enable real-time monitoring, analysis, and optimization. Understanding and identifying the temporal dependencies included in the multivariate time series data that characterize the behavior of the system are crucial for improving the effectiveness of Digital Twins. Long Short-Term Memory (LSTM) networks have been used to represent complex temporal dependencies and identify long-term links in the Industrial Internet of Things (IIoT).
  • 1.3K
  • 03 Nov 2023
Topic Review
DNA Damage Response
Genomic instability is responsible for the progression of acute leukemia, caused by the dysfunction of the DDR genes and activation of certain oncogenes
  • 1.3K
  • 26 Oct 2020
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