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Topic Review
Perturbation
In astronomy, perturbation is the complex motion of a massive body subjected to forces other than the gravitational attraction of a single other massive body. The other forces can include a third (fourth, fifth, etc.) body, resistance, as from an atmosphere, and the off-center attraction of an oblate or otherwise misshapen body.
  • 1.3K
  • 28 Oct 2022
Topic Review
Pectins and The Health Effects
Pectin, a plant-derived polysaccharide, possesses immense technological and biological application value. Several variables influence pectin’s physicochemical aspects, resulting in different fermentations, interactions with receptors, and other functional properties. Some of those variables are molecular weight, degree of methylation and blockiness, and monosaccharide composition. Cancer cell cytotoxicity, important fermentation-related byproducts, immunomodulation, and technological application were found in cell culture, animal models, and preclinical and clinical assessments. 
  • 1.3K
  • 07 Aug 2023
Topic Review
Tropomyosin mutation Glu173Ala
Substitution of Glu173 for Ala in Tpm3.12 (E173A) is associated with congenital muscle weakness. It was found that this mutation increases myofilament Ca2+-sensitivity and inhibits in vitro actin-activated ATPase activity of myosin subfragment-1 at high Ca2+. In order to determine the critical conformational changes in myosin, actin and tropomyosin caused by the mutation, we used the polarized fluorimetry technique. We observed changes in the spatial arrangement of actin monomers and myosin heads, and in the position of the mutant tropomyosin on the thin filaments in muscle fibres at various ATPase cycle stages. At low Ca2+ the E173A mutant tropomyosin shifts abnormally towards the inner domains of actin at all stages of the cycle. The number of switched-on actin monomers and strong-binding myosin heads increases even at relaxation. Contrarily, at high Ca2+ the amount of the myosin heads strongly bound with F-actin slightly decreases. The changes in the balance of the strongly bound myosin heads in the ATPase cycle may underlie the occurrence of muscle weakness. W7, an inhibitor of troponin Ca2+-sensitivity, restores the number of strong-binding myosin heads at high Ca2+ and inhibits it at relaxation, suggesting the possibility of using Ca2+-desensitizers to reduce the damaging effect of the E173A mutation on muscle fibre contractility.
  • 1.3K
  • 27 Oct 2020
Topic Review
Hepatitis B Virus Cure
Hepatitis B virus (HBV) is a small, enveloped, and partially double-stranded DNA virus of the Hepadnaviridae family that infects hepatocytes, establishes its replication cycle, and persists in the nucleus.
  • 1.3K
  • 18 Mar 2021
Topic Review
Ownership of Organization Behavior
Ownership of organization behavior (OOB) is that the psychological influence of the tour leader will affect their behavior, and the psychological consequences of the tour leader will be affected by experience (such as seniority of the team leader or number of tour groups).
  • 1.3K
  • 05 Jul 2021
Topic Review
Thermochemical Recycling of Waste Tyres
Utilising pyrolysis as a waste tyre processing technology has various economic and social advantages, along with the fact that it is an effective conversion method. Despite extensive research and a notable likelihood of success, this technology has not yet seen implementation in industrial and commercial settings. In this review, over 100 recent publications are reviewed and summarised to give attention to the current state of global tyre waste management, pyrolysis technology, and plastic waste conversion into liquid fuel. The study also investigated the suitability of pyrolysis oil for use in diesel engines and provided the results on diesel engine performance and emission characteristics. Most studies show that discarded tyres can yield 40–60% liquid oil with a calorific value of more than 40 MJ/kg, indicating that they are appropriate for direct use as boiler and furnace fuel. It has a low cetane index, as well as high viscosity, density, and aromatic content. According to diesel engine performance and emission studies, the power output and combustion efficiency of tyre pyrolysis oil are equivalent to diesel fuel, but engine emissions (NOX, CO, CO, SOX, and HC) are significantly greater in most circumstances. These findings indicate that tyre pyrolysis oil is not suitable for direct use in commercial automobile engines, but it can be utilised as a fuel additive or combined with other fuels. 
  • 1.3K
  • 23 Jan 2022
Topic Review
Genetics and Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) is the commonest cause of chronic liver disease worldwide. It is closely related to obesity, insulin resistance (IR) and dyslipidemia so much so it is considered the hepatic manifestation of the Metabolic Syndrome. The NAFLD spectrum extends from simple steatosis to nonalcoholic steatohepatitis (NASH), a clinical condition which may progress up to fibrosis, cirrhosis and hepatocellular carcinoma (HCC). NAFLD is a complex disease whose pathogenesis is shaped by both environmental and genetic factors.
  • 1.3K
  • 15 Oct 2021
Topic Review
CRLF1 and CLCF1
Cytokines and their receptors have a vital function in regulating various processes such as immune function, inflammation, haematopoiesis, cell growth and differentiation. The interaction between a cytokine and its specific receptor triggers intracellular signalling cascades that lead to altered gene expression in the target cell and consequent changes in its proliferation, differentiation, or activation.
  • 1.3K
  • 10 Feb 2022
Topic Review
Reminiscence Therapy in Depression Treatment in the Elderly
Reminiscence therapy is a mechanism to help someone remember events from their life. It is often used as a therapy tool for reducing depression, calming behavioral and psychological symptoms of dementia, or affecting mood of the elderly. Although its most common use is for the elderly and people affected with dementia or depression, it has also been used with people of all ages, including children. The reminiscing process can take place in a group or individually or by using technological devices such as mobile devices or robots. It is marked by remembering notable events from the past.
  • 1.3K
  • 03 Mar 2022
Topic Review
Photocatalytic Desulfurization
Desulfurization of fuels such as diesel, gasoline, kerosene, and jet fuel has been a challenging operation and remains critical to the petrochemical industry. The main naturally occurring sulfur-containing organic compounds (SCCs) are sulfides, disulfides, mercaptans, thiophene (Th) and its derivatives (benzothiophene (BT), dibenzothiophenes (DBTs), 4-methylbenzothiophene (4-MBT), 4,6-dimethyldibenzothiophene (4,6-DMDBT), 3,7-dimethyldibenzothiophene (3,7-DMDBT), and 2,8-dimethyldibenzothiophene (2,8-DMDBT)). The presence of these SCCs in fuels is undesirable since they create problems during refining, namely deactivation of some catalysts and corrosion of equipment. Moreover, sulfur compounds release toxic SOx and cause severe environmental problems: water and air pollution, global warming, ecological instability, as well as the harmful impact on living organisms. Many countries (USA, European Union, Japan, China and so on) have introduced strict standards to limit the content of sulfur in fuels to 10 ppm.
  • 1.3K
  • 23 Sep 2022
Topic Review
Vibrational Spectroscopy of Linear Molecules
To determine the vibrational spectroscopy of linear molecules, the rotation and vibration of linear molecules are taken into account to predict which vibrational (normal) modes are active in the infrared spectrum and the Raman spectrum.
  • 1.3K
  • 11 Nov 2022
Topic Review
Transactive Energy
Transactive energy is a highly effective technique for peers to exchange and trade energy resources. Several interconnected blocks, such as generation businesses, prosumers, the energy market, energy service providers, transmission and distribution networks, and so on, make up a transactive energy framework.
  • 1.3K
  • 16 Nov 2022
Topic Review
Rural Internet
Rural Internet describes the characteristics of Internet service in rural areas (also referred to as "the country" or "countryside"), which are settled places outside towns and cities. Inhabitants live in villages, hamlets, on farms and in other isolated houses. Mountains and other terrain can impede rural Internet access. Internet service in many rural areas is provided over voiceband by 56k modem. Poor-quality telephone lines, many of which were installed or last upgraded between the 1930s and the 1960s, often limit the speed of the network to bit rates of 26kbit/s or less. Since many of these lines serve relatively few customers, phone company maintenance and speed of repair of these lines has degraded and their upgrade for modern quality requirements is unlikely. This results in a digital divide. High-speed, wireless Internet service is becoming increasingly common in rural areas. Here, service providers deliver Internet service over radio-frequency via special radio-equipped antennas. Methods for broadband Internet access in rural areas include:
  • 1.3K
  • 18 Nov 2022
Topic Review
Ocular Extra-Intestinal Manifestations in Adults Inflammatory Bowel Disease
Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic, inflammatory, polygenic, multifactorial, and multifactorial illness with unknown etiology. Studies have reported extraintestinal manifestations (EIMs) or issues in several organ systems, including musculoskeletal, dermatologic, ocular, pulmonary, renal, and hepatobiliary systems.
  • 1.3K
  • 15 Dec 2022
Topic Review
Mitochondrial Disorders
Mitochondrial disorders represent a heterogeneous group of genetic disorders with variations in severity and clinical outcomes, mostly characterized by respiratory chain dysfunction and abnormal mitochondrial function. More specifically, mutations in the human synthesis of cytochrome c oxidase 2 (SCO2) gene, encoding the mitochondrial inner membrane Sco2 cytochrome c oxidase (COX) assembly protein, have been implicated in the mitochondrial disorder fatal infantile cardioencephalomyopathy with COX deficiency. 
  • 1.3K
  • 28 Jan 2023
Topic Review
Dasatinib-Mediated Immunomodulatory Effects in Chronic Myeloid Leukemia
Tyrosine kinase inhibitors (TKIs) have been extensively used as a treatment for chronic myeloid leukemia (CML). Dasatinib is a broad-spectrum TKI with off-target effects that give it an immunomodulatory capacity resulting in increased innate immune responses against cancerous cells and viral infected cells.
  • 1.3K
  • 15 Mar 2023
Topic Review
Neurotrophins in the Pathogenesis of Alzheimer’s Disease
The involvement of the changed expression/function of neurotrophic factors in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD), has been suggested. AD is one of the age-related dementias, and is characterized by cognitive impairment with decreased memory function. Developing evidence demonstrates that decreased cell survival, synaptic dysfunction, and reduced neurogenesis are involved in the pathogenesis of AD. On the other hand, it is well known that neurotrophic factors, especially brain-derived neurotrophic factor (BDNF) and its high-affinity receptor TrkB, have multiple roles in the central nervous system (CNS), including neuronal maintenance, synaptic plasticity, and neurogenesis, which are closely linked to learning and memory function. 
  • 1.3K
  • 07 Apr 2023
Topic Review
Docking Studies of Recently Synthesized MAO-B Inhibitors
With the significant growth of patients suffering from neurodegenerative diseases (NDs), novel classes of compounds targeting monoamine oxidase type B (MAO-B) are promptly emerging as distinguished structures for the treatment of the latter. As a promising function of computer-aided drug design (CADD), structure-based virtual screening (SBVS) is being heavily applied in processes of drug discovery and development. The utilization of molecular docking, as a helping tool for SBVS, is providing essential data about the poses and the occurring interactions between ligands and target molecules. 
  • 1.3K
  • 13 Jul 2023
Topic Review
Uses of Magnetic Fields for Health Applications
Early life on Earth evolved in the contexts of temperature, available elements, and molecules (including water), as well as the biophysical boundary conditions of the planet. The latter include gravity (1 g), exogenous and endogenous radiation from particles from beyond Earth and radioactive elements on Earth, and magnetic fields due to the planet’s magnetic field and local concentrations of molecules such as iron. Humans and other animals, plants, and microorganisms have been exposed to a variety of magnetic fields other than the geomagnetic field of Earth and deposits of ferro materials. Magnetic fields, static or electromagnetic, have been used in attempts to improve outcomes for the repair of a variety of tissues.
  • 1.3K
  • 19 Jun 2024
Topic Review
Quantitative Vitamin A Analysis Approaches
Ensuring that animals receive a well-balanced diet and appropriate feed formulation can significantly enhance animal productivity, improve the quality of their products, and promote better animal welfare. Vitamin A, also known as retinol, is a vital micronutrient crucial for maintaining optimal health and well-being in livestock. It plays a central role in various physiological functions, including immune response regulation, vision maintenance, and cellular differentiation. Consequently, the accurate determination of vitamin A levels in animal feed and premixes is essential for ensuring animal health and production. Beyond preventing deficiencies and associated health issues, it forms the foundation for their overall growth and performance.
  • 1.3K
  • 18 Feb 2024
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