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Topic Review
YAP/TAZ Activation in Head and Neck Cancer
The Hippo signaling pathway, originally discovered as a mechanism regulating tissue growth and organ size, transduces intracellular and extracellular signals to regulate the transcriptional co-activators YAP and TAZ. Alterations in the Hippo pathway resulting in persistent YAP and TAZ activation have emerged as major oncogenic drivers. The researchers' analysis of the human Head and neck squamous cell carcinoma (HNSCC) oncogenome revealed multiple genomic alterations impairing Hippo signaling and activating YAP and TAZ, which in turn contribute to HNSCC development. This includes mutations and deletions of the FAT1 gene (29%) and amplification of the WWTR1 (encoding TAZ, 14%) and YAP1 genes (8%), together representing one of the most genetically altered signaling mechanisms in this malignancy. 
  • 2.5K
  • 11 May 2022
Topic Review
Hydrogen Bond
The hydrogen bond may be treated as a local stabilizing interaction that acts between the proton or the electron charge deficient region of hydrogen centre and the electron rich region that is related to one or more centres. This may be named as the two-sites hydrogen bond definition. However in numerous studies the A-H proton donating bond with the positively charged H-atom and the proton acceptor, say B, being the electron rich centre are taken into account. Thus so-called A-H∙∙∙B hydrogen bridges are often considered. In such a way the three-sites hydrogen bond definition may be proposed that the hydrogen bond is the A-H∙∙∙B local stabilizing system with the proton situated between two A and B electron rich sites, most often closer to one of them, forming the A-H covalent bond; both A and B may correspond to one or more atomic centres.
  • 2.5K
  • 07 Sep 2021
Topic Review
The Key Precursors of Brain Acetyl-CoA
Acetyl-CoA  is a principal substrate feeding tricarboxylic acid (TCA). cycle  and energy production. Brain displays high demand for energy due to high frequency of neuronal depolarizatio-repolarization cycles. Therefore, adequate provision of acetyl-CoA precursors is critical factor for proper neuronal activity and survival. 
  • 2.5K
  • 22 Sep 2022
Topic Review
Zeaxanthin and Lutein in Humans
Many factors in the environment (including radiation, pathogens, and various stresses) prompt internal formation of oxidants that orchestrate beneficial adjustments in human metabolism and but can also lead to damage and disease. To prevent adverse effects of these oxidants, humans require antioxidants and anti-inflammatories, many of which are vitamins and other essential micronutrients that must be consumed with the diet. The xanthophylls zeaxanthin and lutein are unique human micronutrients that protect the integrity and function of biological membranes – especially in the human eye and brain.
  • 2.5K
  • 16 Feb 2021
Topic Review
Role of MPO in Human Diseases and Inflammation
Myeloperoxidase (MPO), also called hydrogen peroxide oxidoreductase with a particular (EC 1.11.1.7), is an enzyme found in the primary granules of granulocytic cells (neutrophils, eosinophils, and, to a lesser extent, monocytes). Lymphocytes lack MPO enzyme activity. However, the most common sources are neutrophils, where the enzyme is located at the lysosomal level in the azurophil granules.
  • 2.5K
  • 27 Sep 2022
Topic Review
Sex-Reversed Females of Salmonid Fish
Sex-reversed females (SRFs; masculinised females, neomales) are genetically females; however, owing to masculinisation, they are capable of producing spermatozoa.
  • 2.5K
  • 12 May 2021
Topic Review
Neurodegeneration in Multiple Sclerosis
Neurodegeneration in multiple sclerosis is believed to underlie disease progression and permanent disability. Many mechanisms of neurodegeneration in MS have been proposed, such as mitochondrial dysfunction, oxidative stress, neuroinflammation, and most recently RNA-binding protein dysfunction. Studying RNA-binding protein dysfunction addresses a gap in our understanding of the pathogenesis of MS, which may allow for novel therapies to be generated to attenuate neurodegeneration before irreversible central nervous system damage occurs.
  • 2.5K
  • 29 Jun 2021
Topic Review
Electrodiffusion in Neuroscience and NPP-Equations
There are two main processes governing the ionic transport, i.e., diffusion—the particle motion caused by a gradient of concentration, and migration—motion of ions caused by a gradient of electrical potential. These two processes are referred to as electrodiffusion. Electrodiffusion of electrolytes serves as a mean for communication in the nervous system. It can directly affect the excitatory transmission in the synaptic cleft. Electrodiffusion maintains the local ions concentration in brain extracellular spaces at heathy levels but may be also involved in the propagation of epileptic seizures during pathological conditions. The accurate interpretation of physiological observations requires better understanding of the underlying electrodiffusion phenomena.The description of electrodiffusion is very often performed using the Nernst–Planck–Poisson (NPP) model. It has been acknowledged that the spatiotemporal dynamics of the ion concentrations in thin dendrites and dendritic spines of nerve cells follow the Nernst–Planck equation, and sub-membrane currents in neuronal membrane have already been successfully described using the NPP model.
  • 2.5K
  • 29 Apr 2021
Topic Review
B-cell non-Hodgkin lymphoma
The term B-cell non-Hodgkin lymphoma (B-NHL) encompasses different neoplasms characterized by an abnormal proliferation of lymphoid B cells.
  • 2.5K
  • 13 Jan 2022
Topic Review
Nature and Cultural Aspects of Astaxanthin
Astaxanthin (AX), a lipid-soluble pigment belonging to the xanthophyll carotenoids family, has recently garnered significant attention due to its unique physical properties, biochemical attributes, and physiological effects.
  • 2.5K
  • 13 Oct 2023
Topic Review
Hsp70 and Hsp90
Hsp70, Hsp90, and their co-chaperones are crucial members of the proteostasis network that are able to recognize misfolded proteins, aberrant condensates and protein aggregates, triaging proteins for refolding or degradation. These members of the chaperome are considered major sentinels impeding the molecular processes that lead to cell damage in the course of degenerative proteinopathies. Indeed, Hsp70, Hsp90 and their co-chaperones are increasingly recognized as therapeutic targets for the development of treatments against prevalent protein misfolding diseases.
  • 2.5K
  • 23 Dec 2020
Topic Review
L-Carnitine in Autism Spectrum Disorder
L-carnitine plays an important role in the functioning of the central nervous system, and especially in the mitochondrial metabolism of fatty acids. Altered carnitine metabolism, abnormal fatty acid metabolism in patients with autism spectrum disorder (ASD) has been documented. ASD is a complex heterogeneous neurodevelopmental condition that is usually diagnosed in early childhood. Patients with ASD require careful classification as this heterogeneous clinical category may include patients with an intellectual disability or high functioning, epilepsy, language impairments, or associated Mendelian genetic conditions. L-carnitine participates in the long-chain oxidation of fatty acids in the brain, stimulates acetylcholine synthesis (donor of the acyl groups), stimulates expression of growth-associated protein-43, prevents cell apoptosis and neuron damage and stimulates neurotransmission.
  • 2.4K
  • 16 May 2022
Topic Review
Bone ECM Signaling
Bone mineral density, a bone matrix parameter frequently used to predict fracture risk, is not the only one to affect bone fragility. Other factors, including the extracellular matrix (ECM) composition and microarchitecture, are of paramount relevance in this process. The bone ECM is a noncellular three-dimensional structure secreted by cells into the extracellular space, which comprises inorganic and organic compounds. The main inorganic components of the ECM are calcium-deficient apatite and trace elements, while the organic ECM consists of collagen type I and noncollagenous proteins. Bone ECM dynamically interacts with osteoblasts and osteoclasts to regulate the formation of new bone during regeneration. Thus, the composition and structure of inorganic and organic bone matrix may directly affect bone quality. Moreover, proteins that compose ECM, beyond their structural role have other crucial biological functions, thanks to their ability to bind multiple interacting partners like other ECM proteins, growth factors, signal receptors and adhesion molecules. Thus, ECM proteins provide a complex network of biochemical and physiological signals.
  • 2.4K
  • 17 Dec 2020
Topic Review
GLP-1R Signaling
Glucagon-like peptide-1 receptor (GLP-1R) is a critical therapeutic target for type 2 diabetes mellitus (T2DM). The GLP-1R cellular signaling mechanism relevant to insulin secretion and blood glucose regulation has been extensively studied. Numerous drugs targeting GLP-1R have entered clinical treatment. Novel functional molecules with reduced side effects and enhanced therapeutic efficacy are still in high demand. 
  • 2.4K
  • 06 Feb 2023
Topic Review
Artemisia Genus as Biopesticides
The Artemisia L. genus includes over 500 species with worldwide distribution and diverse chemical composition. Many secondary metabolites of this genus are known for their antimicrobial, insecticidal, parasiticidal, and phytotoxic properties, which recommend them as possible biological control agents against plant pests. Given the negative impact of synthetic pesticides on human health and on the environment, Artemisia‐derived biopesticides and their nanoformulations emerge as promising ecofriendly alternatives to pest management.
  • 2.4K
  • 02 Jul 2021
Topic Review
Molecular Structure and Biochemistry of Post-Proline Cleaving Enzymes
Post-proline cleaving enzymes (PPCEs) are involved in various biological functions in diverse taxa of organisms including microbes, fungi, animals, and plants.
  • 2.4K
  • 24 May 2022
Topic Review
Coriandrum sativum L.
Coriandrum sativum (C. sativum), belonging to the Apiaceae (Umbelliferae) family, is widely recognized for its uses in culinary and traditional medicine. C. sativum contains various phytochemicals such as polyphenols, vitamins, and many phytosterols, which account for its properties including anticancer, anti-inflammatory, antidiabetic, and analgesic effects.
  • 2.4K
  • 13 Jan 2022
Topic Review
Antioxidant Activity of Natural Products
Natural products identified with potential antioxidant activity need to be further evaluated in the cellular model. Antioxidant activity of a large number of natural products will not extrapolate its performance in the biological system, either in vitro as cellular assays or in vivo as animal model studies. Thus, it is necessary to examine the bioavailability, metabolism and mechanism of action in a living system to prove potential antioxidant activities of new natural products.
  • 2.4K
  • 09 Dec 2021
Topic Review
LncRNA-Protein Interactions
LncRNA can act as gene regulators, and like other epigenetic mechanisms are involved in numerous biological processes. They achieve their regulatory function with their ability to interact with a wide range of biological molecules, such as other nucleic acids and proteins. These lncRNA-protein interactions (LPI) are involved in many biological pathways including development and disease. A variety of computational LPI predictors exist, each applying different strategies to achieve their goals, and are dependent on a few biological databases containing subsets of experimentally validated LPI. Most modern lncRNA-protein interaction (LPI) prediction algorithms use machine learning approaches, where algorithms are trained on large datasets with attributes of interest.
  • 2.4K
  • 05 Jul 2021
Topic Review
Fe Uptake and Transport
The mode of iron (Fe) uptake and transport in cereal species is distinguished from that in other plant species by the synthesis and utilization of phytosiderophores, which are a group of Fe chelators involved in Fe mobilization from the environment as well as within the plant body. In this entry, the overview of the molecular mechanisms behind the Fe uptake and transport is presented, highlighting the commonality and diversity among cereal species.
  • 2.4K
  • 29 Oct 2020
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