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Topic Review
MAPK Pathways in Cancer Metastasis
Metastasis is perhaps the most common reason for treatment failure in cancer patients, as well as the leading cause of cancer-related death. Mitogen-activated protein kinase (MAPK) are serine/threonine-protein kinases that can be activated by a variety of extracellular stimuli including growth factors, cytokines, insulin, environmental factors, and oxidative and genotoxic stress. It is becoming increasingly clear that MAPKs are involved in all the steps required for hyperproliferating cells to develop into metastatic tumors. However, scholars are currently lacking in vivo data to fully understand how MAPK signaling pathways can affect the progression of metastatic disease. 
  • 5.5K
  • 26 May 2022
Topic Review
Cemetery Tourism
Cemetery tourism (thanatourism) is a specific sub-section of dark tourism that is becoming increasingly popular. Tourists wander through burial grounds with the aim of discovering the artistic, architectural, historical, and scenic heritage that often abounds in cemeteries. The changing perception of cemeteries from a place for burial towards a cultural heritage space provides several opportunities for tourism. It enables the community to explore the development of products and services that help the destination to gain new income while preserving its heritage.
  • 5.5K
  • 10 Mar 2022
Topic Review
Greenery Systems
Urbanization, when it is not planned carefully, are highly effecting the urban heat island. To mitigate the problem, urbanization planning must take into consideration the implementation of greenery systems and sustainable ecosystems for buildings as part of the solution in addition to the outer space. The mitigation techniques that are influencing the urban heat index may be the greenery systems applied on buildings, or urban green spaces that include large land and large scale systems, such as lakes and parks. The objective of the current article is to compile, discusses and compare the previous studies on greenery systems, like green roofs and green walls, how they are supporting the energy saving and improve thermal conditions in the building sector, as well as improving the urban heat index. The fundamental  of greenery systems, which are thermal insulation, evapotranspiration, and shading effect, are also discussed. The benefits of greenery systems are including the improvement of stormwater management,  improvement of air quality, the reduction of sound pollution, the reduction of carbon dioxide, and the improvement of aesthetic building value. 
  • 5.5K
  • 29 Oct 2020
Topic Review
Co-Pyrolysis and Its Mechanism
Usually, a single feedstock is employed in pyrolysis for anoxygenic generation of biochar together with bio-oil at elevated temperatures (350–600 °C). Bio-oil produced through pyrolysis can be upgraded to crude oil after some modification. However, these modifications of bio-oil are one of the major drawbacks for its large-scale adoption, as upgradation increases the overall cost. Therefore, in recent years the scientific community has been researching co-pyrolysis technology that involves the pyrolysis of lignocellulosic biomass waste with non-biodegradable waste. Co-pyrolysis reduces the need for post-modification of bio-oil, unlike pyrolysis of a single feedstock. 
  • 5.5K
  • 18 Jul 2022
Topic Review
Improvised Artillery in the Syrian Civil War
Improvised artillery in the Syrian Civil War are improvised firearms created and used by factions of the Syrian Civil War, most notably Syrian opposition forces. The weapons include the Hell Cannon and its variants, the Thunder Cannon and the Mortar Cannon. The weapons have been criticized for being inaccurate.
  • 5.5K
  • 21 Oct 2022
Topic Review
Airport Business Model
The growth in demand for air transport caused airports to invest in the development of infrastructure and service quality. Therefore, airports, which are mostly owned and operated by governments, shifted to public enterprise management and multi-business companies to become more competitive and profitable. Massive funding was required to refurbish airports and improve their cost efficiency. The airports were tasked with finding managerial instruments to provide a new business model. 
  • 5.5K
  • 22 Jul 2022
Topic Review
Puma (IFV)
The Puma is a Germany infantry fighting vehicle (IFV) (Schützenpanzer or short SPz) designed to replace the aging Marder IFVs currently in service with the German Army. Production of the first batch of 350 vehicles began in 2010 and is scheduled for completion by the second quarter of 2021. A second batch of 210 Pumas has received funding. Mass production began on 6 July 2009. The companies responsible for this project are Krauss-Maffei Wegmann and Rheinmetall Landsysteme, who created a joint venture in the form of Projekt System Management GmbH (PSM). The Puma is one of the world's best-protected IFVs, while still having a high power-to-weight ratio.
  • 5.5K
  • 28 Sep 2022
Topic Review
Flat Panel Display
Flat-panel displays are electronic viewing technologies used to enable people to see content (still images, moving images, text, or other visual material) in a range of entertainment, consumer electronics, personal computer, and mobile devices, and many types of medical, transportation and industrial equipment. They are far lighter and thinner than traditional cathode ray tube (CRT) television sets and video displays and are usually less than 10 centimetres (3.9 in) thick. Flat-panel displays can be divided into two display device categories: volatile and static. Volatile displays require that pixels be periodically electronically refreshed to retain their state (e.g., liquid-crystal displays (LCD)). A volatile display only shows an image when it has battery or AC mains power. Static flat-panel displays rely on materials whose color states are bistable (e.g., e-book reader tablets from Sony), and as such, flat-panel displays retain the text or images on the screen even when the power is off. As of 2016, flat-panel displays have almost completely replaced old CRT displays. In many 2010-era applications, specifically small portable devices such as laptops, mobile phones, smartphones, digital cameras, camcorders, point-and-shoot cameras, and pocket video cameras, any display disadvantages of flat-panels (as compared with CRTs) are made up for by portability advantages (thinness and lightweightness). Most 2010s-era flat-panel displays use LCD and/or LED technologies. Most LCD screens are back-lit as color filters are used to display colors. Flat-panel displays are thin and lightweight and provide better linearity and they are capable of higher resolution than typical consumer-grade TVs from earlier eras. The highest resolution for consumer-grade CRT TVs was 1080i; in contrast, many flat-panels can display 1080p or even 4K resolution. As of 2016, some devices that use flat-panels, such as tablet computers, smartphones and, less commonly, laptops, use touchscreens, a feature that enables users to select onscreen icons or trigger actions (e.g., playing a digital video) by touching the screen. Many touchscreen-enabled devices can display a virtual QWERTY or numeric keyboard on the screen, to enable the user to type words or numbers. A multifunctional monitor (MFM) is a flat-panel display that has additional video inputs (more than a typical LCD monitor) and is designed to be used with a variety of external video sources, such as VGA input, HDMI input from a VHS VCR or video game console and, in some cases, a USB input or card reader for viewing digital photos). In many instances, an MFM also includes a TV tuner, making it similar to a LCD TV that offers computer connectivity.
  • 5.5K
  • 25 Nov 2022
Topic Review
Calcium Propionate in Dairy Cows
Calcium propionate is a safe and reliable food and feed additive. It can be metabolized and absorbed by humans and animals as a precursor for glucose synthesis. In addition, calcium propionate provides essential calcium to mammals. In the perinatal period of dairy cows, many cows cannot adjust to the tremendous metabolic, endocrine, and physiological changes, resulting in ketosis and fatty liver due to a negative energy balance (NEB) or milk fever induced by hypocalcemia. On hot weather days, cow feed (TMR or silage) is susceptible to mildew, which produces mycotoxins. These two issues are closely related to dairy health and performance. Propionic acid is the primary gluconeogenic precursor in dairy cows and one of the safest mold inhibitors. Therefore, calcium propionate, which can be hydrolyzed into propionic acid and Ca2+ in the rumen, may be a good feed additive for alleviating NEB and milk fever in the perinatal period of dairy cows. It can also be used to inhibit TMR or silage deterioration in hot weather and regulate rumen development in calves. This paper reviews the application of calcium propionate in dairy cows.
  • 5.5K
  • 27 Oct 2020
Topic Review
Water Content of Different Plant Parts
Water is indispensable for the functioning of all biological organisms. In plants, water has several functions in comparison to other organisms, including transport processes and transpiration. The mechanical properties of plants are highly dependent on water and its localization in tissues and cells.
  • 5.5K
  • 15 Mar 2023
Topic Review
Family of Meghan, Duchess of Sussex
Members of the Markle and Ragland families have been related by marriage to the British royal family since the wedding of Meghan Markle and Prince Harry, Duke of Sussex, on May 19, 2018, when she became the Duchess of Sussex. The Markle (originally spelled Merckel) family is of German descent and originates in Alsace on the modern French–German border, and her ancestors moved to the United States in the 18th century; among her father's other ancestors are American settlers of English, Dutch, and Irish descent. Her mother is of African American descent and her early ancestors hailed from the U.S. state of Georgia.
  • 5.5K
  • 27 Nov 2022
Topic Review
Orion
Orion, one of the most recognizable constellations in the night sky, is steeped in mythology and astronomical significance. Named after the legendary hunter from Greek mythology, Orion is adorned with bright stars, including the famous Orion's Belt, and hosts a plethora of celestial wonders, such as the Orion Nebula, making it a favorite among stargazers.
  • 5.5K
  • 15 Mar 2024
Topic Review
Water-Related Issues in Bhutan
Water for hydropower in Bhutan has been in focus as compared to that allocated for irrigation, industries, and environmental demand. The demand for water in Bhutan has also increased in the last decade due to population increase, changes in lifestyle, and economic advancements through tourism and hydropower projects.
  • 5.5K
  • 28 Apr 2021
Topic Review
Phosphoribosyl Pyrophosphate Synthetase
Phosphoribosyl pyrophosphate synthetase (PRS EC 2.7.6.1) is a rate-limiting enzyme that irreversibly catalyzes the formation of phosphoribosyl pyrophosphate (PRPP) from ribose-5-phosphate and adenosine triphosphate (ATP). This key metabolite is required for the synthesis of purine and pyrimidine nucleotides, the two aromatic amino acids histidine and tryptophan, the cofactors nicotinamide adenine dinucleotide (NAD+) and nicotinamide adenine dinucleotide phosphate (NADP+), all of which are essential for various life processes. Despite its ubiquity and essential nature across the plant and animal kingdoms, PRPP synthetase displays species-specific characteristics regarding the number of gene copies and architecture permitting interaction with other areas of cellular metabolism. The impact of mutated PRS genes in the model eukaryote Saccharomyces cerevisiae on cell signalling and metabolism may be relevant to the human neuropathies associated with PRPS mutations. Human PRPS1 and PRPS2 gene products are implicated in drug resistance associated with recurrent acute lymphoblastic leukaemia and progression of colorectal cancer and hepatocellular carcinoma.
  • 5.5K
  • 02 Aug 2022
Topic Review
Turing Reduction
In computability theory, a Turing reduction from a problem A to a problem B, is a reduction which solves A, assuming the solution to B is already known (Rogers 1967, Soare 1987). It can be understood as an algorithm that could be used to solve A if it had available to it a subroutine for solving B. More formally, a Turing reduction is a function computable by an oracle machine with an oracle for B. Turing reductions can be applied to both decision problems and function problems. If a Turing reduction of A to B exists then every algorithm for B can be used to produce an algorithm for A, by inserting the algorithm for B at each place where the oracle machine computing A queries the oracle for B. However, because the oracle machine may query the oracle a large number of times, the resulting algorithm may require more time asymptotically than either the algorithm for B or the oracle machine computing A, and may require as much space as both together. The first formal definition of relative computability, then called relative reducibility, was given by Alan Turing in 1939 in terms of oracle machines. Later in 1943 and 1952 Stephen Kleene defined an equivalent concept in terms of recursive functions. In 1944 Emil Post used the term "Turing reducibility" to refer to the concept. A polynomial-time Turing reduction is known as a Cook reduction, after Stephen Cook.
  • 5.5K
  • 14 Oct 2022
Topic Review
Long and Short Scale
The long and short scales are two of several naming systems for integer powers of ten which use some of the same terms for different magnitudes. For whole numbers smaller than 1,000,000,000 (109), such as one thousand or one million, the two scales are identical. For larger numbers, starting with 109, the two systems differ. For identical names, the long scale proceeds by powers of one million, whereas the short scale proceeds by powers of one thousand. For example, "one billion" means one thousand millions in the short scale, while it means one million millions in the long scale. The long scale system uses additional terms for the intervening values, typically replacing the word ending -ion with -iard.
  • 5.5K
  • 24 Nov 2022
Topic Review
Ethical Dilemmas in Emerging Technologies
Emerging technologies have featured prominently in the research on technology ethics, which is progressively concentrating on early-stage intervention in technological innovation. Techno Ethics (TE) serves as a multidisciplinary research field that incorporates theories and techniques from various domains including communications systems, sociology, innovation, ethical theories, and principles. Cybercrime is an umbrella term for all illicit activities made possible by access to an IT infrastructure including unauthorized access, unlawful data comparison interception, system disruption, digital identity fraud, etc. The goal of cybersecurity (counterpart to cybercrime) is to assist people in mitigating risks in their systems, networks, and data, ensuring security and privacy. To secure cyberspace, formal and informal resources, including equipment, people, infrastructure, services, policies, training, and technologies are used. As more firms post details to demonstrate their public commitment to ethical ideals while promoting security, discussions regarding ethical standards for emerging technologies are becoming more common. 
  • 5.5K
  • 13 Feb 2023
Topic Review
Okara and Gut
Okara is a white-yellow fibrous residue consisting of the insoluble fraction of the soybean seeds remaining after extraction of the aqueous fraction during the production of tofu and soymilk, and is generally considered a waste product. It is packed with a significant number of proteins, isoflavones, soluble and insoluble fibers, soyasaponins, and other mineral elements, which are all attributed with health merits. With the increasing production of soy beverages, huge quantities of this by-product are produced annually, which poses significant disposal problems and financial issues for producers. Extensive studies have been done on the biological activities, nutritional values, and chemical composition of okara as well as its potential utilization. Owing to its peculiar rich fiber composition and low cost of production, okara might be potentially useful in the food industry as a functional ingredient or good raw material and could be used as a dietary supplement to prevent varied ailments such as prevention of diabetes, hyperlipidemia, obesity, as well as to stimulate the growth of intestinal microbes and production of microbe-derived metabolites (xenometabolites), since gut dysbiosis (imbalanced microbiota) has been implicated in the progression of several complex diseases.
  • 5.5K
  • 31 Jan 2021
Topic Review
Polymers in Wastewater Treatment
The utilization of various types of natural and modified polymers for removing toxicant dyes in wastewater generated by the dye industry is reviewed in this article. Dye wastewater contains large amounts of metals, surfactants, and organic matter, which have adverse effects on human health, potentially causing skin diseases and respiratory problems. The removal of dyes from wastewaters through chemical and physical processes has been addressed by many researchers. Currently, the use of natural and modified polymers for the removal of dyes from wastewater is becoming more common. Although modified polymers are preferred for the removal of dyes, due to their biodegradability and non-toxic nature, large amounts of polymers are required, resulting in higher costs. 
  • 5.5K
  • 20 Oct 2020
Topic Review
Tomatine
Tomatine (sometimes called tomatin or lycopersicin) is a glycoalkaloid, found in the stems and leaves of tomato plants, and in the fruits at much lower concentrations. Chemically pure tomatine is a white crystalline solid at standard temperature and pressure. Tomatine is sometimes confused with the glycoalkaloid solanine, which is found in potatoes.
  • 5.5K
  • 26 Oct 2022
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