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Topic Review
Higher Education Quality Standards in University Colleges
Universities worldwide strive to achieve excellence in research, learning, teaching, and community services, which are the pillars of their strategic plans.
  • 1.3K
  • 28 Aug 2023
Topic Review
Chitosan-Based Delivery Systems for Carotenoids
Carotenoids are secondary metabolites present in microorganisms (bacteria, yeast, fungi, and microalgae) and higher plants. They cannot be produced by the human organism. In nature, their principal role is to attract different light wavelengths and transfer their energy to chlorophylls, a function occurring mainly in photosynthetic organisms. Moreover, they can act as photo-protectors, precursors of hormonal substances, antistress secondary metabolites, and attractive agents in plant–insect interaction.
  • 1.3K
  • 27 Sep 2023
Topic Review
Research Progress on the Features of Rural Settlements
During the development of rural settlements, the loss of distinctive rural characteristics, caused by the contradiction between urban expansion and the ideal of pastoralism, has attracted widespread attention from researchers worldwide.
  • 1.3K
  • 08 Nov 2023
Topic Review
Immune Landscape in Multiple Myeloma
Multiple myeloma (MM) is a dyscrasia of plasma cells (PCs) characterized by abnormal immunoglobulin (Ig) production. The disease remains incurable due to a multitude of mutations and structural abnormalities in MM cells, coupled with a favorable microenvironment and immune suppression that eventually contribute to the development of drug resistance. The bone marrow microenvironment (BMME) is composed of a cellular component comprising stromal cells, endothelial cells, osteoclasts, osteoblasts, and immune cells, and a non-cellular component made of the extracellular matrix (ECM) and the liquid milieu, which contains cytokines, growth factors, and chemokines. The bone marrow stromal cells (BMSCs) are involved in the adhesion of MM cells, promote the growth, proliferation, invasion, and drug resistance of MM cells, and are also crucial in angiogenesis and the formation of lytic bone lesions. Classical immunophenotyping in combination with advanced immune profiling using single-cell sequencing technologies has enabled immune cell-specific gene expression analysis in MM to further elucidate the roles of specific immune cell fractions from peripheral blood and bone marrow (BM) in myelomagenesis and progression, immune evasion and exhaustion mechanisms, and development of drug resistance and relapse. 
  • 1.3K
  • 15 Nov 2023
Topic Review
Monitoring and Evaluation of National Vaccination Implementation
An effective Monitoring and Evaluation (M&E) framework helps vaccination programme managers determine progress and effectiveness for agreed indicators against clear benchmarks and targets. Improving national vaccination programme implementation requires collection and analysis of data on relevant vaccination components. Monitoring and evaluation (M&E) or more recent Monitoring, Evaluation, Accountability and Learning (MEAL) frameworks support decision-making by consolidating available information on agreed indicators, benchmarked targets, and methods to collect, analyse, and report necessary data to strengthen vaccination programmes.
  • 1.3K
  • 22 Apr 2022
Topic Review
Biomarkers of Stress in Different Animal Species
When studying stress in animals, it is important to understand the types of stress and their classification, and how to assess the stress levels in different animal species using different matrices accurately and precisely. Among biomarkers, it is crucial to always identify the reliable ones depending on the applicability of the sample, as the markers must be highly correlated with the specific pathophysiological aspects of the particular stress. 
  • 1.3K
  • 15 Nov 2022
Topic Review
Marine Carotenoids Astaxanthin
Photodamage is an umbrella term that includes general phototoxicity, photoaging, and cancer caused by UVR. All these phenomena are mediated by direct or indirect oxidative stress and inflammation and are strictly connected one to the other. Astaxanthin (ASX) is a peculiar marine carotenoids characterized by outstanding antioxidant properties. In particular, ASX has an exceptional efficacy in counteracting all categories of photodamages, in vitro and in vivo, thanks to both antioxidant potential and activation of different pathways.
  • 1.3K
  • 18 Feb 2021
Topic Review
LGMD2D myotubes
LGMD2D (LGMD-R3 according to the new nomenclature) is a rare autosomal recessive disease affecting striated muscle. It belongs to the group of limb girdle muscular dystrophies because of the involvement of the proximal musculature of the shoulders and pelvic girdle. LGMD2D is caused by mutations in the SGCA gene coding for α-sarcoglycan (SG).  
  • 1.3K
  • 01 Nov 2020
Topic Review
Versatile Nutraceutical Potentials of Watermelon
Watermelon (Citrulus lantus) is an important horticultural crop which belongs to the Curcubitaceae family. The nutraceutical potential of watermelon has been illustrated by several researchers, which makes it a better choice of functional food. Watermelon has been used to treat various ailments, such as cardio-vascular diseases, aging related ailments, obesity, diabetes, ulcers, and various types of cancers. The medicinal properties of watermelon are attributed by the presence of important phytochemicals with pharmaceutical values such as lycopene, citrulline, and other polyphenolic compounds. Watermelon acts as vital source of l-citrulline, a neutral-alpha amino acid which is the precursor of l-arginine, an essential amino acid necessary for protein synthesis. Supplementation of l-citrulline and lycopene displayed numerous health benefits in in vitro and in vivo studies. Similarly, the dietary intake of watermelon has proven benefits as functional food in humans for weight management. 
  • 1.3K
  • 18 Nov 2020
Topic Review
Smart Porous Multi-Stimulus Polysaccharide-Based Biomaterials
Recently, tissue engineering and regenerative medicine studies have evaluated smart biomaterials as implantable scaffolds and their interaction with cells for biomedical applications. Porous materials have been used in tissue engineering as synthetic extracellular matrices, promoting the attachment and migration of host cells to induce the in vitro regeneration of different tissues. Biomimetic 3D scaffold systems allow control over biophysical and biochemical cues, modulating the extracellular environment through mechanical, electrical, and biochemical stimulation of cells, driving their molecular reprogramming. In this review, first we outline the main advantages of using polysaccharides as raw materials for porous scaffolds, as well as the most common processing pathways to obtain the adequate textural properties, allowing the integration and attachment of cells. The second approach focuses on the tunable characteristics of the synthetic matrix, emphasizing the effect of their mechanical properties and the modification with conducting polymers in the cell response. The use and influence of polysaccharide-based porous materials as drug delivery systems for biochemical stimulation of cells is also described. Overall, engineered biomaterials are proposed as an effective strategy to improve in vitro tissue regeneration and future research directions of modified polysaccharide-based materials in the biomedical field are suggested.
  • 1.3K
  • 24 Nov 2020
Topic Review
Tauvid™
Tauvid has been approved by the U.S. Food and Drug Administration (FDA) in 2020 for positron emission tomography (PET) imaging of adult patients with cognitive impairments undergoing evaluation for Alzheimer’s disease (AD) based on tau pathology.
  • 1.3K
  • 18 Mar 2021
Topic Review
Treatment of Human Babesiosis
Babesiosis is an emerging tick-borne disease caused by apicomplexan parasites of the genus Babesia. With its increasing incidence worldwide and the risk of human-to-human transmission through blood transfusion, babesiosis is becoming a rising public health concern.
  • 1.3K
  • 16 Sep 2021
Topic Review
Synthetic Oleanolic Acid Derivatives
Oleanolic acid (3β-hydroxyolean-12-en-28-oic acid) is a pentacyclic triterpenoid, widely occurring in the plant kingdom, which includes edible and medicinal plants. The richest source of oleanolic acid (OA) are the leaves of the olive plant. Common culinary spices such as garden thyme and clove plants, as well as fruits, are also sources of OA.
  • 1.3K
  • 22 Sep 2021
Topic Review
B Corps’ Social Media Communications
A growing emphasis on stakeholder values of social and environmental responsibility and the triple bottom line (TBL) thinking led to the emergence of B Corporations (hereafter B Corps). B Corps are social enterprises that are committed to the TBL and certified by B Lab, a non-profit organization that assesses corporations’ overall impact of their decisions on their workers, customers, community, and the environment. Although B Corps serves as a catalyst for sustainable development, little is known about how they communicate on social media during a crisis. In this study, we examined the social media communications of B Corps to (1) identify salient topics and themes, (2) analyze how these themes align with the TBL, and (3) evaluate social media performance against industry benchmarks. We focused on the apparel, footwear, and accessories (AFA) sectors in the U.S. and chose Twitter, a platform known for crisis communication. Using a qualitative method, we found four topics and 21 underlying themes. Topics related to social/environmental issues and COVID-19 were most dominant, followed by product/brand promotions. Further classification of specific themes and cases from a TBL perspective demonstrated that, overall, B Corps in the AFA sectors leveraged various approaches to promote balance between each TBL dimension. Lastly, although collectively B Corps exceeded some of the Twitter industry benchmarks, at an individual level, most brands had room for improvement to build a stronger community and promote synergy among the three pillars of the TBL.
  • 1.3K
  • 23 Sep 2021
Topic Review
Gluten Enteropathy
Gluten enteropathy, namely Celiac disease (CD), is a hereditary predisposed disease, accompanied by the atrophy of the small intestine mucosa, associated malabsorption syndrome, and the development of various deficiency conditions. Celiac disease is caused by food containing gluten—the proteins of cereals that are the diet of the majority of the world population. Some immunogenic peptides of gluten proteins formed during digestion, mainly gliadins from wheat, rye, and barley, are resistant to proteolysis by human digestive peptidases and cause CD in predisposed people.
  • 1.3K
  • 19 Oct 2021
Topic Review
Point-Based Groundwater Monitoring
The initial type of groundwater investigation started with level measurements with different types of instruments, which is called point-based groundwater monitoring. These methods and instruments include steel tape, electronic measuring tapes, pressure transducers, sounding devices, test drilling, geophysical investigation techniques, piezometers, digital water level recorders, exploratory well drilling, and isotopes, etc.
  • 1.3K
  • 15 Feb 2022
Topic Review
Insights into the Pharmacological Effects of Flavonoids
Flavonoids are widely occurring secondary metabolites of plants. Currently, there is a trend of article numbers increasing, which focuses on the computer modeling of flavonoid interactions with biological targets. Such studies help to accumulatethe data on lead compounds that can find medicinal implementation, including COVID-19. Flavanonol taxifolin demonstrated wound-healing activity. Luteolin, apigenin, and wogonin, which can be classified as flavones, show induced neutrophil apoptosis and have potential as neutrophil apoptosis-inducing anti-inflammatory, proresolution agents.
  • 1.3K
  • 10 Jun 2022
Topic Review
Monocular Depth Estimation with Deep Learning
Significant advancements in robotics engineering and autonomous vehicles have improved the requirement for precise depth measurements. Depth estimation (DE) is a traditional task in computer vision that can be appropriately predicted by applying numerous procedures.  This is vital in disparate applications such as augmented reality and target tracking. Conventional monocular DE (MDE) procedures are based on depth cues for depth prediction. Various deep learning techniques have demonstrated their potential applications in managing and supporting the traditional ill-posed problem.
  • 1.3K
  • 12 Aug 2022
Topic Review
Gift
A gift or a present is an item given to someone without the expectation of payment or anything in return. An item is not a gift if that item is already owned by the one to whom it is given. Although gift-giving might involve an expectation of reciprocity, a gift is meant to be free. In many countries, the act of mutually exchanging money, goods, etc. may sustain social relations and contribute to social cohesion. Economists have elaborated the economics of gift-giving into the notion of a gift economy. By extension the term gift can refer to any item or act of service that makes the other happier or less sad, especially as a favor, including forgiveness and kindness. Gifts are also first and foremost presented on occasions such as birthdays and holidays.
  • 1.3K
  • 06 Oct 2022
Topic Review
Information Culture
Information culture is closely linked with Information Technology, Information Systems and the digital world. It is difficult to give one definition of Information Culture and many approaches exist.
  • 1.3K
  • 21 Oct 2022
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