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Topic Review
Renal Nanomedicine
The kidneys are vital organs performing several essential functions. Their primary function is the filtration of blood and the removal of metabolic waste products as well as fluid homeostasis. Renal filtration is the main pathway for drug removal, highlighting the importance of this organ to the growing field of nanomedicine. The kidneys (i) have a key role in the transport and clearance of nanoparticles (NPs), (ii) are exposed to potential NPs’ toxicity, and (iii) are the targets of diseases that nanomedicine can study, detect, and treat. 
  • 1.4K
  • 12 Aug 2021
Topic Review
Computer Modeling of the Heart
Computer modeling of the electrophysiology of the heart has undergone significant progress. A healthy heart can be modeled starting from the ion channels via the spread of a depolarization wave on a realistic geometry of the human heart up to the potentials on the body surface and the ECG.
  • 1.4K
  • 25 Aug 2021
Topic Review
Trypanothione Reductase: Structural Analysis for Drug Discovery
Leishmaniasis, Chagas disease, and human African trypanosomiasis (HAT), also known as sleeping sickness, are vector borne zoonosis that affect millions of people worldwide and lead to the death of about 100,000 humans per year. Among several molecular targets proposed, trypanothione reductase (TR) is of particular interest for its critical role in controlling the parasite’s redox homeostasis. 
  • 1.4K
  • 25 Nov 2021
Topic Review
Anaplastic large cell lymphoma, anaplastic lymphoma kinase (ALK)-negative
Anaplastic large cell lymphoma (ALCL) is a subtype of T-cell lymphoma composed of large cells and a characteristic strong and diffuse expression of the activation marker CD30 (>75% of the cells). ALCL is composed of large epithelioid and anaplastic cells and cells with horseshoe-shaped nucleus (hallmark cells). This lymphoma is divided into two major groups based on the presence/absence of the rearrangement and of the expression of anaplastic lymphoma kinase (ALK) into ALK-positive and ALK-negative. The latter is currently classified into systemic, primary cutaneous, and breast implant-associated ALCL.
  • 1.4K
  • 02 Dec 2021
Topic Review
Stylometry and Numerals Usage: Benford's Law and Beyond
Benford’s Law is a strange manifestation of the law of large numbers (understood as the combined action of a large number of random factors leading to a result that is almost independent of the case).
  • 1.4K
  • 11 Jan 2022
Topic Review
Low-Grade Serous Carcinoma of the Ovary
Low-grade serous carcinoma (LGSC) of the ovary is a rare histological subtype of epithelial ovarian carcinoma. It has distinct clinical behavior and a specific molecular profile. Compared with high-grade serous carcinoma, this tumor presents at a younger age, has an indolent course, and is associated with prolonged survival. LGSC can arise de novo or originate following a serous borderline tumor (SBT). 
  • 1.4K
  • 14 Mar 2022
Topic Review
Range Anxiety
Range anxiety is the fear that a vehicle has insufficient range to reach its destination and would thus strand the vehicle's occupants. The term, which is primarily used in reference to battery electric vehicles (BEVs), is considered to be one of the major barriers to large-scale adoption of all-electric cars. The term range anxiety was first reported in the press on September 1, 1997, in the San Diego Business Journal by Richard Acello referring to worries of GM EV1 electric car drivers. On July 6, 2010, General Motors filed to trademark the term, stating it was for the purpose of "promoting public awareness of electric vehicle capabilities". The Norwegian equivalent rekkeviddeangst was assigned second place in a list of Norwegian "words of the year" for 2013 by the Norwegian Language Council. The main strategies to alleviate range anxiety among electric car drivers are the deployment of extensive charging infrastructure, the development of higher battery capacity at a cost-effective price, battery swapping technology, use of range extenders, accurate navigation and range prediction and availability of free loan vehicles for long trips. According to a study by the American Automobile Association, the cure to range anxiety is owning an electric vehicle.
  • 1.4K
  • 18 Nov 2022
Topic Review
Pyrroloiminoquinones
Pyrroloiminoquinones are a group of cytotoxic alkaloids most commonly isolated from marine sponges. Structurally, they are based on a tricyclic pyrrolo[4,3,2-de]quinoline core and encompass marine natural products such as makaluvamines, tsitsikammamines and discorhabdins.
  • 1.4K
  • 22 Dec 2022
Topic Review
Pyrvinium Pamoate Mechanisms of Action as an Anti-Cancer Agent
Pyrvinium, a lipophilic cation belonging to the cyanine dye family, has been used in the clinic as a safe and effective anthelminthic for over 70 years. Its structure, similar to some polyaminopyrimidines and mitochondrial-targeting peptoids, has been linked with mitochondrial localization and targeting. Unsurprisingly for a small-molecule compound, pyrvinium pamoate (PP) has been shown to act through multiple mechanisms. The majority of the published articles assessing PP specifically as an anticancer therapeutic have focused on two main MOA, which appear to be at the root of PP action: inhibition of the WNT pathway and inhibition of mitochondrial function.
  • 1.4K
  • 30 Dec 2022
Topic Review
Plant Growth-Promoting Rhizobacteria in Medicinal Plants
Plants are constantly exposed to both biotic and abiotic stresses which limit their growth and development and reduce productivity. In order to tolerate them, plants initiate a multitude of stress-specific responses which modulate different physiological, molecular and cellular mechanisms. The microbial community in the rhizosphere (known as the rhizomicrobiome) undergoes intraspecific as well as interspecific interaction and signaling. The rhizomicrobiome, as biostimulants, play a pivotal role in stimulating the growth of plants and providing resilience against abiotic stress. Such rhizobacteria which promote the development of plants and increase their yield and immunity are known as PGPR (plant growth promoting rhizobacteria). On the basis of contact, they are classified into two categories, extracellular (in soil around root, root surface and cellular space) and intracellular (nitrogen-fixing bacteria). They show their effects on plant growth directly (i.e., in absence of pathogens) or indirectly. Generally, they make their niche in concentrated form around roots, as the latter exude several nutrients, such as amino acids, lipids, proteins, etc. Rhizobacteria build a special symbiotic relationship with the plant or a section of the plant’s inner tissues. There are free-living PGPRs with the potential to work as biofertilizers. Additionally, studies show that PGPRs can ameliorate the effect of abiotic stresses and help in enhanced growth and development of plants producing therapeutically important compounds. 
  • 1.4K
  • 20 Jan 2023
Topic Review
Efficient Pollination Technology of Crops
Pollination is essential to maintain ecosystem balance and agricultural production. Domesticated bee pollination, which is easy to feed and manage, and mechanized pollination, which is not restricted by the environment, are considered the main technical means to alleviate the “pollinating insect crisis”. The selection of pollination method should be based on the physiological characteristics of crops and the actual environmental conditions of natural pollination. The pollination ability of bees is closely related to the status of the bees. Maintaining the pollination ability of bees in a reasonable range is the goal of bee pollination services. Colony state control technology needs to develop in two directions. First, there is a need to develop colony state monitoring technology based on multi-feature information fusion and to explore the self-regulation mechanisms of the colony in response to various factors. Second, based on these self-regulation mechanisms, there is a need to develop a low-cost and non-invasive bee colony state and pollination capacity estimation model, monitoring technology, and equipment based on single feature information. The goals of mechanized pollination are “efficiency” and “precision”. Mechanized pollination technology needs to be developed in two directions. First, the mechanisms of pollen abscission, transport, and sedimentation in different crops and mechanized pollination conditions should be explored. Second, research and development of efficient and accurate pollination equipment and technology based on the integration of multiple technologies such as pneumatic assistance, auxiliaries, static electricity, target, variables, and navigation, are needed.
  • 1.4K
  • 07 Feb 2023
Topic Review
Idiopathic Pulmonary Fibrosis and Lipid Metabolism
It has become evident that lipid metabolism is involved in the fibrosis of lungs, and various reports have been made at the cellular level as well as at the organic level. The balance among eicosanoids, sphingolipids, and lipid composition has been reported to be involved in fibrosis, with particularly close attention being paid to a bioactive lipid “lysophosphatidic acid (LPA)” and its pathway.
  • 1.4K
  • 20 Feb 2023
Topic Review
Cyberattacks in Wireless Sensor Networks
As an Internet of Things (IoT) technological key enabler, Wireless Sensor Networks (WSNs) are prone to different kinds of cyberattacks. WSNs have unique characteristics, and have several limitations which complicate the design of effective attack prevention and detection techniques.
  • 1.4K
  • 19 Sep 2023
Topic Review
Antidepressant-like Effect of Flavonoids
Depressive disorders are among the most disabling diseases experienced around the world. The search for new pharmacological alternatives to treat depression is a global priority. In preclinical research, molecules obtained from plants, such as flavonoids, have shown promising antidepressant-like properties through several mechanisms of action that have not been fully elucidated, including crossing of the blood brain barrier (BBB). 
  • 1.4K
  • 23 Sep 2022
Topic Review
Molecular and Clinical Aspects of Anti-VEGF Drugs
Vascular endothelial growth factor (VEGF) is a major angiogenic molecule that induces choroid neovascularization (CNV). VEGF has five ligand member in human: VEGFA, VEGFB, VEGFC, VEGFD, and placenta growth factor, and there are three receptors: VEGFR1, VEGFR2 and VEGFR3. VEGFs play an important role in vascular development and choroid maintenance in the normal eye. The basolateral secretion of VEGF from the retinal pigment epithelium (RPE) continues throughout life and mediates RPE survival. However, the increase in VEGF secretion from RPE and the loss of RPE polarity are causes of the pathologic CNV condition. Since the off- label bevacizumab started to be used to treat CNV, neovascular age-related macular degeneration (nAMD), there are several anti-VEGF agents approved: pegaptanib, ranibizumab, aflibercept, conbercept, brolucizumab, faricimab.
  • 1.4K
  • 04 Sep 2023
Topic Review
Additive Manufacturing for Electromobility
Additive manufacturing (AM) offers the possibility to produce components in a resource-efficient and environmentally friendly way. AM can also be used to optimise the design of components in mechanical and physical terms. In this way, functionally integrated, lightweight, highly efficient, and innovative components can be manufactured with the help of additive manufacturing in terms of Industry 4.0. The development of drivetrains for electromobility offers far more potential than simply replacing the combustion engine with an electric motor. With the possibility of power-specific AM design, and the resulting wide variety of electric machine designs, new drivetrain topologies can be designed. The gradual reduction in mechanical drive components improves the overall efficiency of the drivetrain (tank to wheel). With regard to metal 3D printing, it is possible to combine components, functionalise them, and design them using lightweight construction approaches, so as to incur weight and component savings. 
  • 1.4K
  • 02 Nov 2022
Topic Review
The Multifaceted Sensemaking Theory
There are several key sensemaking models and theories that have attracted a lot of attention among researchers and practitioners. The adaptation and application of sensemaking has varied by field of study, organizational type, and industry. Sensemaking has been acknowledged as the catalyst for shifting research focus from a system-centered to user-centered phenomena in the field of information sciences. Sensemaking has also shifted the focus away from sender and receiver transactions in communications studies to constructions that are entangled with time, places, and perspectives.
  • 1.4K
  • 30 Jan 2024
Topic Review
Vascular Calcification
A variety of actively regulated processes on cellular and systemic level with various contributing and inhibiting factors can result in vascular calcification (VC). Currently, treatment is limited to management of risk factors including regulation of the calcium-phosphate metabolism. Due to the complex pathophysiology, the mechanisms underlying ectopic calcification are studied in various, distinctly different research models. Beside in vitro models using cells of different origin, ex vivo settings using aortic tissue are available. In addition, various in vivo disease-induced animal models are currently used in research. All of these experimental settings depict (patho)physiologic mechanisms within the vascular calcification process.
  • 1.4K
  • 29 Oct 2020
Topic Review
Climate-Related Prudential Risks
Climate change creates financial risks to the safety and soundness of banks, insurers and the wider financial system, posing a significant threat to the stability of the financial system. Climate-related financial and sustainability risks are already starting to crystallise and have the potential to increase substantially in the future. For instance, physical risks that arise from increasing the severity and frequency of climate and weather-related events may lead to a reduction in asset values, a fall in profitability and an increase in the cost of settling underwriting losses for insurers. On the other hand, adjustment towards a carbon-neutral economy may prompt a reassessment of asset values, a fluctuation in energy prices, and a deterioration of the creditworthiness of borrowers, potentially leading to credit losses. While there is a pressing need for central banks, regulators and financial institutions to accelerate their capacity to assess and manage such financial risks that may result from climate change, academic research will be a key impetus to drive and support the ongoing efforts of the financial sector and the regulatory bodies in building capacity to address these risks. 
  • 1.4K
  • 15 Jul 2020
Topic Review
Polysaccharide-Based Edible Coatings for Plum
Polysaccharide-based edible coatings are served as an attractive preservation method for postharvest maintenance of most fruits. The current study examined the effect of carboxymethylcellulose (CMC)- and pectin (Pec)-based edible coatings on titratable acidity (TA), firmness; vitamin C (vit C); total soluble solids (TSS); pH; total phenolics; anthocyanin and flavonoid contents; total antioxidant capacity (based on 1,1-Diphenyl-2-picryl-hydrazyl hydrate (DPPH)); the activities of peroxidase (POD), polyphenol oxidase (PPO) and polygalacturonase (PG) enzymes; and weight loss during cold storage.
  • 1.4K
  • 18 Sep 2020
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