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Topic Review
Characterization of Ti/SnO2 Interface by X-ray Photoelectron Spectroscopy
The Ti/SnO2 interface has been investigated in situ via the technique of x-ray photoelectron spectroscopy. Thin films (in the range from 0.3 to 1.1 nm) of titanium were deposited on SnO2 substrates via the e-beam technique. The deposition was carried out at two different substrate temperatures, namely room temperature and 200 °C. The photoelectron spectra of tin and titanium in the samples were found to exhibit significant differences upon comparison with the corresponding elemental and the oxide spectra. These changes result from chemical interaction between SnO2 and the titanium overlayer at the interface. The SnO2 was observed to be reduced to elemental tin while the titanium overlayer was observed to become oxidized. Complete reduction of SnO2 to elemental tin did not occur even for the lowest thickness of the titanium overlayer. The interfaces in both the types of the samples were observed to consist of elemental Sn, SnO2, elemental titanium, TiO2, and Ti-suboxide. 
  • 1.4K
  • 26 Jan 2022
Topic Review
Iron in Porphyrias
Despite the strict link between iron and heme, the role of iron in the different types of porphyrias, particularly as a risk factor for disease development/progression or as a potential therapeutic target or molecule, is still being debated, since contrasting results have emerged from clinical observations, in vitro studies and animal models.
  • 1.4K
  • 28 Jan 2022
Topic Review
Signal Transduction by VIP and PACAP Receptors
Homeostasis of the human immune system is regulated by many cellular components, including two neuropeptides, VIP and PACAP, primary stimuli for three class B G protein-coupled receptors, VPAC1, VPAC2, and PAC1. Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) regulate intestinal motility and secretion and influence the functioning of the endocrine and immune systems. Inhibition of VIP and PACAP receptors is an emerging concept for new pharmacotherapies for chronic inflammation and cancer, while activation of their receptors provides neuroprotection. Major molecular switches of VPAC1, VPAC2, and PAC1 may act as triggers for receptor activation and compare them with similar non-covalent interactions changing upon activation that were observed for other GPCRs. Interhelical interactions in VIP and PACAP receptors that are important for agonist binding and/or activation provide a molecular basis for the design of novel selective drugs demonstrating anti-inflammatory, anti-cancer, and neuroprotective effects. As to the genetic variants of VIP, PACAP, and their receptors on signalling mediated by endogenous agonists, this sequence diversity resulting from gene splicing has a significant impact on agonist selectivity and potency as well as on the signalling properties of VIP and PACAP receptors. 
  • 1.4K
  • 28 Mar 2022
Topic Review
Construction Projects Based on the Causes of Claims
Conflict in human relations is unavoidable; therefore, it can occur in construction projects that are full of many human relationships. These conflicts can lead to claims if interlocutors do not agree. The main result of the claims is the delay and overrun of costs in construction projects. Additionally, poor management of claims affects the success of construction projects and their budget and schedule. Moreover, controlling claims ensures the successful completion of construction projects and minimizes delays and disputes. 
  • 1.4K
  • 22 Apr 2022
Topic Review
Conventional Approaches of Nuclear Magnetic Resonance Statistics
Nuclear magnetic resonance (NMR) measurements combined with chemometrics allow achieving a great amount of information for the identification of potential biomarkers responsible for a precise metabolic pathway. These kinds of data are useful in different fields, ranging from food to biomedical fields, including health science. The investigation of the whole set of metabolites in a sample, representing its fingerprint in the considered condition, is known as metabolomics and may take advantage of different statistical tools. The new frontier is to adopt self-learning techniques to enhance clustering or classification actions that can improve the predictive power over large amounts of data.
  • 1.4K
  • 09 May 2022
Topic Review
Model Predictive Traffic Control by Bi-Level Optimization
A bi-level model for traffic signal optimization is developed. The model predictive framework is applied for traffic control in an urban traffic network. The potential of the bi-level formalization is used to increase the space of control influences with simultaneous evaluation of the green light and cycle durations. Thus, the increased control space allows more traffic parameters to be considered, such as vehicles queues and traffic flows. A particular modification of the bi-level control is applied for the synchronization of the traffic lights in the network. The model predictive approach is used for the real-time management of the traffic in the network. The control implementations are constrained by the shortest evaluated cycle.
  • 1.4K
  • 11 May 2022
Topic Review
Nrf2 in Neurogenesis and Disease Development
Neurogenesis occurs in the brain during embryonic development and throughout adulthood. Neurogenesis occurs in the hippocampus and under normal conditions and persists in two regions of the brain—the subgranular zone (SGZ) in the dentate gyrus of the hippocampus and the subventricular zone (SVZ) of the lateral ventricles. The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) is a major regulator of metabolism, protein quality control, and antioxidative defense, and is linked to neurogenesis. 
  • 1.4K
  • 13 Jul 2022
Topic Review
List of Psychiatric Medications by Condition Treated
This is a list of psychiatric medications used by psychiatrists and other physicians to treat mental illness or distress. The list is ordered alphabetically according to the condition or conditions, then by the generic name of each medication. The list is not exhaustive and not all drugs are used regularly in all countries. Some medications treat multiple conditions and appear multiple times.
  • 1.4K
  • 09 Nov 2022
Topic Review
Ratooning
Ratooning is the agricultural practice of harvesting a monocot crop by cutting most of the above-ground portion but leaving the roots and the growing shoot apices intact so as to allow the plants to recover and produce a fresh crop in the next season. This practice is widely used in the cultivation of crops such as rice, sugarcane, banana, and pineapple. Ratoon crops cannot be perennially renewed, and may be harvested only for a few seasons, as a decline in yield tends to occur due to increased crowding, damage by pests and diseases, and decreasing soil fertility.
  • 1.4K
  • 15 Nov 2022
Topic Review
MLT (Hacktivist)
MLT, real name Matt Telfer, is a former grey hat computer hacker and member of TeaMp0isoN. MLT was arrested in May 2012 in relation to his activities within TeaMp0isoN, a computer-hacking group which claimed responsibility for many high-profile attacks, including website defacements of the United Nations , Facebook, NATO, BlackBerry, T-Mobile USA and several other large sites in addition to high-profile denial-of-service attacks and leaks of confidential data.
  • 1.4K
  • 18 Nov 2022
Topic Review
Optimization Control Strategies in Building Energy Management Systems
Due to rising energy demands, the industrial revolution has brought with it a slew of new issues. This phenomenon fosters the development of more resource-efficient control approaches. The building sector has a huge potential to mitigate energy demand using intelligent energy management systems (IEMS) and the concept of the internet of energy (IoE). The IoE combines features of a smart grid and the internet of things (IoT). The IoT refers to internet-based architecture in two ways: communication allows the system to be monitored and controlled in real-time via cloud computing or another internet service. It is proven that the potential of IoE-based building energy management systems (BEMS) will enhance the performance of future building energy utilization. The key idea of BEMS is monitoring and controlling the energy consumption in buildings with the aim of reducing emissions. The design of BEMS has taken into account factors such as efficiency, scalability, robustness, flexibility, and an ability to sense the environment and make decisions autonomously.
  • 1.4K
  • 27 Feb 2023
Topic Review
Molecular Virology
Molecular virology is the study of viruses on a molecular level. Viruses are submicroscopic parasites that replicate inside host cells. They are able to successfully infect and parasitize all kinds of life forms- from microorganisms to plants and animals- and as a result viruses have more biological diversity than the rest of the bacterial, plant, and animal kingdoms combined. Studying this diversity is the key to a better understanding of how viruses interact with their hosts, replicate inside them, and cause diseases.
  • 1.4K
  • 31 Oct 2022
Topic Review
Exopolysaccharides from Lactic Acid Bacteria
Microbial polysaccharides have interesting and attractive characteristics for the food industry, especially when produced by food grade bacteria. Polysaccharides produced by lactic acid bacteria (LAB) during fermentation are extracellular macromolecules of either homo or hetero polysaccharidic nature, and can be classified according to their chemical composition and structure. The most prominent exopolysaccharide (EPS) producing lactic acid bacteria are Lactobacillus, Leuconostoc, Weissella, Lactococcus, Streptococcus, Pediococcus and Bifidobacterium sp. The EPS biosynthesis and regulation pathways are under the dependence of numerous factors as producing-species or strain, nutrient availability, and environmental conditions, resulting in varied carbohydrate compositions and beneficial properties.
  • 1.4K
  • 15 Dec 2020
Topic Review
AlphaFold Predictions in Viral Research
AlphaFold, a modern deep-learning algorithm, enables the prediction of protein structure to a high level of accuracy. It has been applied in numerous studies in various areas of biology and medicine. Viruses are biological entities infecting eukaryotic and procaryotic organisms. They can pose a danger for humans and economically significant animals and plants, but they can also be useful for biological control, suppressing populations of pests and pathogens. AlphaFold can be used for studies of molecular mechanisms of viral infection to facilitate several activities, including drug design.
  • 1.4K
  • 10 May 2023
Topic Review Peer Reviewed
Physical-Chemical Properties of Nano-Sized Phyllosilicates: Recent Environmental and Industrial Advancements
Phyllosilicates are common minerals that include the most widely known micas and clay minerals. These minerals are found in several natural environments and have unique physical-chemical features, such as cation exchange capacity (CEC) and surface charge properties. When phyllosilicates are nano-sized, their physical-chemical properties are enhanced from those of the micro-sized counterpart. Because of their unique crystal chemical and physical-chemical features, kinetics, and particle size, nano-sized clay minerals (i.e., kaolinite, montmorillonite/illite) and micas (i.e., muscovite) are of great interest in several fields spanning from environmental applications to engineered materials. This paper aims to overview the recent developments of environmental protection and technological applications employing nano-sized natural micas and clay minerals. Emphasis is given to the role that the unique physical-chemical properties of montmorillonite, vermiculite, kaolinite, and muscovite play in nanoparticle formulations, manufacture, and technical performance.
  • 1.4K
  • 06 Dec 2023
Topic Review
Treatment of Corneal Burn Injuries
Ocular chemical and thermal burns are frequent causes of hospitalization and require immediate interventions and care. Various surgical and pharmacological treatment strategies are employed according to damage severity. Controlling inflammation and neovascularization while promoting normal ocular surface anatomy and function restoration is the principal aim. In the most severe cases, when epithelial healing is severely affected, reconstruction of the ocular surface may be a valid option, which, however, requires expertise, adequate instruments, and qualified donors. Numerous endogenous and exogenous strategies have been considered for corneal repair. Among these, stem cells and their derivatives have offered numerous attractive possibilities in finding an effective way in stimulating corneal regeneration.
  • 1.4K
  • 27 Jan 2021
Topic Review
Polymer–Lipid Pharmaceutical Nanocarriers
Some issues in pharmaceutical therapies such as instability, poor membrane permeability, and bi-oavailability of drugs can be solved by the design of suitable delivery systems based on the com-bination of two pillar classes of ingredients: polymers and lipids. At the same time, modern tech-nologies are required to overcome production limitations (low productivity, high energy con-sumption, expensive setup, long process times) to pass at the industrial level.
  • 1.4K
  • 19 Feb 2021
Topic Review
Grape Stem Extracts
The application of plant extracts for therapeutic purposes has been used in traditional medicine because plants contain bioactive compounds with beneficial properties for health. Currently, the use of these compounds that are rich in polyphenols for the treatment and prevention of diseases such as cancer, diabetes, and cardiovascular diseases, many of them related to oxidative stress, is gaining certain relevance. Polyphenols have been shown to have antimutagenic, antioxidant, and anti-inflammatory properties.
  • 1.4K
  • 18 May 2021
Topic Review
An Instrument for Occupation-Based Research
Occupational therapy practice is based on the fundamental assumption that meaningful occupations play a key role in achieving and maintaining health and wellbeing by facilitating personal engagement and accomplishment [1]. This practice framework rests largely on the fact that occupational performance should involve an occupational balance (OB), i.e., a sense of harmony between occupations, becoming a necessary condition to ensure that occupations properly perform a process for obtaining health and wellness. From an occupational perspective of health, it should be noted that there is a variety of risk factors that can affect the right use, choice, opportunity, or balance in an occupation, thereby resulting in occupational dysfunction, which may also involve other negative consequences such as occupational deprivation, occupational alienation, or occupational imbalance.
  • 1.4K
  • 28 Jul 2021
Topic Review
E-Government Service
Electronic government serves to connect activities between society and the government. People are familiar with the term electronic government and have used other government applications to support their activities, such as searching for regional information, tourism potential, e-filing, and electronic citizen cards. The evolution of electronic government is occurring very quickly to facilitate the complex problems faced today and prepare for changes in the future. The role of government cannot be separated from service activities to the general citizen. One of the digital channels is electronic government, that can be used as a two-way service media that can adapt to changes both technically, as well as in design and strategy. Electronic government quality is an important domain that can influence citizens’ responses to the quality of facilities provided by the government. Connection quality is a user’s concept of what is felt that affects the quality of credence and contentment to the perceived experience.
  • 1.4K
  • 05 Aug 2021
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