Your browser does not fully support modern features. Please upgrade for a smoother experience.
Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort by:
Most Viewed Latest Alphabetical (A-Z) Alphabetical (Z-A)
Filter:
All Topic Review Biography Peer Reviewed Entry Video Entry
Topic Review
Neurodegeneration in Diabetic Retinopathy
Diabetic retinopathy (DR) remains a critical global burden, with 103.12 million individuals affected and an estimated increase to 160.5 million by 2045. It represents a common and preventable complication of both type 1 and type 2 diabetes affecting the adult working population. Neurodegeneration is a critical element of diabetic retinopathy pathogenesis. The neuronal cells’ apoptosis contributes to microvascular impairment and blood–retinal barrier breakdown.
  • 1.4K
  • 03 Mar 2022
Topic Review
CIDE Proteins in Human Health
Cell death-Inducing DNA Fragmentation Factor Alpha (DFFA)-like Effector (CIDE) proteins have emerged as lipid droplet-associated proteins that regulate fat metabolism. There are three members in the CIDE protein family—CIDEA, CIDEB, and CIDEC (also known as fat-specific protein 27 (FSP27)). CIDEA and FSP27 are primarily expressed in adipose tissue, while CIDEB is expressed in the liver. Originally, based upon their homology with DNA fragmentation factors, these proteins were identified as apoptotic proteins. However, recent studies have changed the perception of these proteins, redefining them as regulators of lipid droplet dynamics and fat metabolism, which contribute to a healthy metabolic phenotype in humans. Despite various studies in humans and gene-targeting studies in mice, the physiological roles of CIDE proteins remains elusive.
  • 1.4K
  • 07 Jun 2022
Topic Review
Mid-Infrared Supercontinuum Generation in Fluoroindate Glass Fibers
Supercontinuum (SC) generation that leads to the emission of broadband radiation has been extensively studied. In particular, SC sources encompassing the wavelength range of 2–5 μm have attracted considerable interest in the last decade, and a continuous increase in the output power and spectrum width has been observed. To enable broadband and high-power SC generation, suitable nonlinear media combined with appropriate pump sources must be used, maintaining the output as spectrally flat. The emergence of specialty glass fibers, such as fluoroindate fibers, as well as the advances in fiber-based pulsed oscillators and amplifiers, have accelerated the development of high-power SC systems operating in the mid-infrared spectral band.
  • 1.4K
  • 11 Jun 2022
Topic Review
Novel Agent with the Terminal Phenoxy Group
The terminal phenoxy group is a moiety of many drugs in use today. Numerous literature reports indicated its crucial importance for biological activity; thus, it is a privileged scaffold in medicinal chemistry. Most often, the presence of the phenoxy moiety provided the chances for the compound to match the target, ensuring selectivity, the π–π interaction, or increase the ability to form the hydrogen bonds by the oxygen ether atom.
  • 1.4K
  • 01 Sep 2022
Topic Review
Implications of Ferroptosis in Cardiovascular Disease
Ferroptosis has recently been demonstrated to be a novel regulated non-apoptotic cell death characterized by iron-dependence and the accumulation of lipid peroxidation that results in membrane damage. Ferroptosis plays an essential role in the development of diverse cardiovascular diseases (CVDs), such as hemochromatosis-associated cardiomyopathy, doxorubicin-induced cardiotoxicity, ischemia/reperfusion (I/R) injury, heart failure (HF), atherosclerosis, and COVID-19–related arrhythmias.
  • 1.4K
  • 07 Sep 2022
Topic Review
Anti-Cancer Effects of Atrial Natriuretic Peptides
The atrial natriuretic peptide (ANP), a cardiovascular hormone, plays a pivotal role in the homeostatic control of blood pressure, electrolytes, and water balance and is approved to treat congestive heart failure. In addition, there is a growing realization that ANPs might be related to immune response and tumor growth. The anti-inflammatory and immune-modulatory effects of ANPs in the tissue microenvironment are mediated through autocrine or paracrine mechanisms, which further suppress tumorigenesis. In cancers, ANPs show anti-proliferative effects through several molecular pathways. Furthermore, ANPs attenuate the side effects of cancer therapy. Therefore, ANPs act on several hallmarks of cancer, such as inflammation, angiogenesis, sustained tumor growth, and metastasis. 
  • 1.4K
  • 12 Oct 2022
Topic Review
IntelliStar
The IntelliStar was the fifth-generation successor to the WeatherStar systems used by the United States cable and satellite television channel The Weather Channel (TWC), that is used to insert local forecasts and current weather information (such as the "Local on the 8s" segments within its program schedule) into TWC's programming. Like the WeatherStar, it is installed at the cable provider's headend. The IntelliStar has many enhanced features over its predecessor, the Weather Star XL. Like all other WeatherStar systems, the IntelliStar receives its data over a satellite connection and over the Internet. However, unlike the rest of the systems, it has the capability to receive more complex information in a more efficient manner. It also has a DualFeed feature, which allows a selection of two different video feeds. In the event of inclement weather, the DualFeed option would switch from the first (network) feed, to a second (localized) feed, providing weather information to a specific STAR or network of STARs. By doing this, the specified network of STARs could be addressed with weather updates, versus the entire national network of STARs (where such information would be irrelevant). It also has an improved graphics display and dynamic radar capabilities. HiRAD (High Resolution Aggregated Data) technology – which was added to the IntelliStar in 2006 – allows The Weather Channel to choose any city, town or landmark as an observation or forecast site and provide data. Occasionally, the HiRAD function will fail, in which case the National Weather Service sites are used (only the current conditions – and previously, the eight-city product and regional/metro products – are affected significantly). In May 2015, it was announced that all IntelliStar units would be replaced with either the IntelliStar 2 or the IntelliStar 2 Jr. by October 1, 2015. The IntelliStar was discontinued on November 16, 2015.
  • 1.4K
  • 16 Nov 2022
Topic Review
Ketoprofen Lysine Salt as Pharmacological Treatment for SARS-CoV-2
COVID-19 is an infective disease resulting in widespread respiratory and non-respiratory symptoms prompted by SARS-CoV-2 infection. Interaction between SARS-CoV-2 and host cell receptors prompts activation of pro-inflammatory pathways which are involved in epithelial and endothelial damage mechanisms even after viral clearance. Since inflammation has been recognized as a critical step in COVID-19, anti-inflammatory therapies, including both steroids and non-steroids as well as cytokine inhibitors, have been proposed. Early treatment of COVID-19 has the potential to affect the clinical course of the disease regardless of underlying comorbid conditions. Non-steroidal anti-inflammatory drugs (NSAIDs), which are widely used for symptomatic relief of upper airway infections, became the mainstay of early phase treatment of COVID-19.
  • 1.4K
  • 11 Jan 2023
Topic Review
Biochemistry of Antioxidants and Their Mode of Action
Antioxidants are a class of a multitude of chemical substances clearly associated with large health benefits and lower risks of various age-related diseases.
  • 1.4K
  • 11 Apr 2023
Topic Review
Features and Barriers of Hydrogen Combustion
After reviewing hydrogen and hydrogen blends combustion characteristics (laminar and turbulent flame speeds, adiabatic flame temperature, preferential diffusion), combustion applications in both thermo-electric power generation and hard-to-abate industry sectors are considered, highlighting the main issues due to hydrogen addition related to safety, pollutant emissions, and potentially negative effects on industrial products.
  • 1.4K
  • 25 Oct 2023
Topic Review
Phototaxis in Ants
Ants are one of the largest insect groups, with the most species and individuals in the world, and they have an important ecological function. Ants are not only an important part of the food chains but are also one of the main decomposers on the Earth; they can also improve soil fertility, etc. However, some species of ants are harmful to human beings, which leads to people’s panic or worry about coming into contact with these insects during their daily home life or in their tourism or leisure activities. The presence of ants in indoor living facilities and in outdoor green spaces, parks, gardens, and tourist attractions seriously interferes with the leisure life and entertainment activities of all people (especially children). Therefore, it is a matter of public health and environmental protection to ensure ant prevention by adopting green control technology and not merely by spraying pesticides to kill them.
  • 1.4K
  • 22 Nov 2023
Topic Review
Genomic Selection of Complex Traits in Alfalfa
Genomic selection (GS) is an alternative approach in which genome-wide markers are used to determine the genomic estimated breeding value (GEBV) of individuals in a population. In alfalfa (Medicago sativa L.), previous results indicated that low to moderate prediction accuracy values (<70%) were obtained in complex traits, such as yield and abiotic stress resistance. There is a need to increase the prediction value in order to employ GS in breeding programs.
  • 1.4K
  • 09 Dec 2021
Topic Review
Infection Control
Infection control is the discipline concerned with preventing nosocomial or healthcare-associated infection, a practical (rather than academic) sub-discipline of epidemiology. It is an essential, though often underrecognized and undersupported, part of the infrastructure of health care. Infection control and hospital epidemiology are akin to public health practice, practiced within the confines of a particular health-care delivery system rather than directed at society as a whole. Anti-infective agents include antibiotics, antibacterials, antifungals, antivirals and antiprotozoals. Infection control addresses factors related to the spread of infections within the healthcare setting (whether patient-to-patient, from patients to staff and from staff to patients, or among-staff), including prevention (via hand hygiene/hand washing, cleaning/disinfection/sterilization, vaccination, surveillance), monitoring/investigation of demonstrated or suspected spread of infection within a particular health-care setting (surveillance and outbreak investigation), and management (interruption of outbreaks). It is on this basis that the common title being adopted within health care is "infection prevention and control."
  • 1.4K
  • 26 Oct 2022
Topic Review
Satellite Geolocation
Satellite geolocation is the process of locating the origin of a signal appearing on a satellite communication channel. Typically, this process is used to mitigate interference on communication satellites. Usually, these interference signals are caused by human error or equipment failure, but can also be caused by deliberate jamming. Identifying the geographical location of an interfering signal informs the mitigation activity.
  • 1.4K
  • 31 Oct 2022
Topic Review
Base Excision Repair Mechanisms
Base excision repair (BER) corrects forms of oxidative, deamination, alkylation, and abasic single-base damage that appear to have minimal effects on the helix. Since its discovery in 1974, the field has grown in several facets: mechanisms, biology and physiology, understanding deficiencies and human disease, and using BER genes as potential inhibitory targets to develop therapeutics.
  • 1.4K
  • 26 Sep 2023
Topic Review
CDKs in Sarcoma
Sarcomas represent one of the most challenging tumor types to treat due to their diverse nature and our incomplete understanding of their underlying biology. Recent work suggests cyclin-dependent kinase (CDK) pathway activation is a powerful driver of sarcomagenesis. CDK proteins participate in numerous cellular processes required for normal cell function, but their dysregulation is a hallmark of many pathologies including cancer. The contributions and significance of aberrant CDK activity to sarcoma development, however, is only partly understood. Here, we describe what is known about CDK-related alterations in the most common subtypes of sarcoma and highlight areas that warrant further investigation. As disruptions in CDK pathways appear in most, if not all, subtypes of sarcoma, we discuss the history and value of pharmacologically targeting CDKs to combat these tumors. The goals of this review are to (1) assess the prevalence and importance of CDK pathway alterations in sarcomas, (2) highlight the gap in knowledge for certain CDKs in these tumors, and (3) provide insight into studies focused on CDK inhibition for sarcoma treatment. Overall, growing evidence demonstrates a crucial role for activated CDKs in sarcoma development and as important targets for sarcoma therapy.
  • 1.4K
  • 29 Oct 2020
Topic Review
Personality Neuroscience
It has long been understood that a multitude of biological systems, from genetics, to brain networks, to psychological factors, all play a role in personality. Understanding how these systems interact with each other to form both relatively stable patterns of behaviour, cognition and emotion, but also vast individual differences and psychiatric disorders, however, requires new methodological insight. Novel data-driven approaches, such as multilayer networks, may prove to be viable methods for explaining and predicting individual difference with greater veracity through incorporating data at more than one scale. 
  • 1.4K
  • 15 Dec 2020
Topic Review
IAQ in Museum Display Cases
The control of air quality in museum showcases is a growing issue for the conservation of the displayed artefacts. Inside an airtight showcase, volatile substances may rapidly concentrate and favor or directly cause the degradation or other unwanted phenomena on the objects. The role of materials used in the construction of museum display cases as a source of pollutants and volatile compounds dangerous for the cultural heritage integrity is here reviewed with an illustration of consequences and critical damages. Ways of assessing the suitability of materials used either in the construction or in use of the display cases are also discussed altogether with an overview of the possible choices for monitoring the air quality and limiting the concentration of volatile compounds in their interior.
  • 1.4K
  • 29 Mar 2021
Topic Review
Nutrition Care of IBD Patients
Malnutrition is highly prevalent in inflammatory bowel disease (IBD) patients and disproportionately affects those admitted to hospital. Malnutrition is a risk factor for many complications in IBD, including prolonged hospitalization, infection, greater need for surgery, development of venous thromboembolism, post-operative complications, and mortality. Early screening for malnutrition and prompt nutrition intervention if indicated has been shown to prevent or mitigate many of these outlined risk factors. There are many causes of malnutrition in IBD including reduced oral food intake, medications, active inflammation, and prior surgical resections. Hospitalization can further compound pre-existing malnutrition through inappropriate diet restrictions, nil per os (NPO) for endoscopy and imaging, or partial bowel obstruction, resulting in “post-hospital syndrome” after discharge and readmission. 
  • 1.4K
  • 01 Jun 2021
Topic Review
Helminth Fauna of Muskrat (Germany)
The muskrat is a neozoon species that has occupied many countries of continental North Europe after its introduction from north America as fur animals. Due to its burrowing activity it damages river and canal banks and structures of flood control. For this reason, the eradication of this alien species is recommended. Muskrats are also of parasitological interest since they can act as suitable intermediate hosts for Echinococcus multilocularis. On the other hand, little is known on the other helminths that infect muskrats. A total of 130 muskrats of different age groups trapped in different habitats in the Barnim district of the Brandenburg state by a professional hunter were examined for parasites and seven trematodes (Echinostoma sp., Notocotylus noyeri, Plagiorchis elegans, Plagiorchis arvicolae, Psilosostoma simillimum, P. spiculigerum, Opisthorchis felineus and four larval cestode species (Hydatigera taeniaeformis, Taenia martis, Taenia polyacantha, Taenia crassiceps) were detected. Larval stages of E. multilocularis were not found. O. felineus was found for the first time in muskrats in Germany. All the named parasites were present in Europe prior to the introduction of muskrats. With a prevalence of 48.9%, Strobilocercus fasciolaris, the larval stage of the cat tapeworm, H. taeniaeformis, was the most frequent parasite found in adult muskrats. 
  • 1.4K
  • 27 Aug 2021
  • Page
  • of
  • 2728
Featured Entry Collections
>>

Featured Reprints

>>
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Encyclopedia of Engineering
Encyclopedia of Social Sciences
Encyclopedia of Medieval Royal Iconography
Academic Video Service
Feedback