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Topic Review
Proton Transport Chain
Carboxylic acids dissociate in water to carboxylates (R-COO-) and oxonium (H+[H2O]n) ions. The Proton Transport Chain (PTC) hypothesis asserts that enzyme complexes bridge nascent acids and ensure water-free transfer of the intermediate substrate. The PTC hypothesis entails that the concentration of the transferred acid is mathematically infinite and an infinite concentration drives enzymatic reactions unidirectionally. In support of this, a number of enzymes, such as proton-linked monocarboxylate transporters (MCTs), lactate dehydrogenases (LDHs) or sodium/hydrogen exchangers have been experimentally determined to catalyse unidirectionally. In addition, enzyme complexes, such as the pyruvate dehydrogenase complex (PDHc), are also known to catalyse unidirectionally. Scientific concepts, such as the original Citric Acid Cycle proposed that acids are metabolized in a clockwise direction. The PTC hypothesis provides mechanisms, mathematics and law of nature for biological processes.
  • 1.4K
  • 26 Feb 2021
Topic Review
Antimicrobial Resistance of VBNC Bacteria
 Antimicrobial Resistance of VBNC Bacteria means the bacteria that enter the viable but non-culturable (VBNC) state, either through unfavorable environmental conditions or through potentially lethal stress, lose their ability to grow on standard enrichment media, but show a drastically increased tolerance against antimicrobials including antibiotics.
  • 1.4K
  • 16 Feb 2021
Topic Review
Nanobody in CAR-T Therapy
Chimeric antigen receptor (CAR) T therapy represents a form of immune cellular therapy with clinical efficacy and a specific target. A typical chimeric antigen receptor (CAR) construct consists of an antigen binding domain, a transmembrane domain, and a cytoplasmic domain. Nanobod-ies have been widely applied as the antigen binding domain of CAR-T due to their small size, optimal stability, high affinity, and manufacturing feasibility. The nanobody-based CAR struc-ture has shown a proven function in more than ten different tumor-specific targets. After being transduced in Jurkat cells, natural killer cells, or primary T cells, the resulting nanobody-based CAR-T or CAR-NK cells demonstrate anti-tumor effects both in vitro and in vivo. Interestingly, anti-BCMA CAR-T modulated by a single nanobody or bi-valent nanobody displays comparable clinical effects with that of single-chain variable fragment (scFv)-modulated CAR-T. The applica-tion of nanobodies in CAR-T therapy has been well demonstrated from bench to bedside and displays great potential in forming advanced CAR-T for more challenging tasks.
  • 1.4K
  • 21 Feb 2021
Topic Review
Kaolinitic Raw Materials for Ceramics
Eight kaolinitic materials from the Lokoundje River at Kribi were sampled and investigated for their physical, chemical, mineralogical and thermal characteristics in order to evaluate their potential suitability as raw materials in ceramics. The Lokoundje kaolinitic materials are clayey to silty clayey and are predominantly composed of kaolinite and quartz. The alkali (Na2O + K2O) content ranges between 1 and 2.5 wt.%; these low values do not favor vitrification of the ceramics but may be improved through flux amendment. The presence of goethite in some samples limits their utilization in white ceramics. The minerals content, color, metallic sound, cohesion, linear shrinkage, flexural strength, bulk density, water absorption and microstructure were determined. The XRD data reveal that kaolinite and goethite were transformed, respectively, into mullite and hematite. The colors of the fired products are characteristic of their mineral assemblage. The metallic sound is indicative of low vitrification which is confirmed by the presence of cracks due to low flux contents. The cohesion is good to very good, due to the abundance of kaolinite. The physicomechanical properties increase with temperature as well as densification. The geochemical data show that the Lokoundje alluvial clays are suitable for the manufacture of white stoneware tiles. 
  • 1.4K
  • 09 Jul 2021
Topic Review
Digital Economy
With the development of digital technologies such as the Internet and digital industries such as e-commerce, the digital economy has become a new form of economic and social development, which has brought forth a new perspective for environmental governance, energy conservation, and emission reduction. 
  • 1.4K
  • 18 Aug 2021
Topic Review
Green Extraction Techniques Applications in Different Fields
Green extraction techniques (GreETs) emerged in the last decade as greener and sustainable alternatives to classical sample preparation procedures aiming to improve the selectivity and sensitivity of analytical methods, simultaneously reducing the deleterious side effects of classical extraction techniques (CETs) for both the operator and the environment. The implementation of improved processes that overcome the main constraints of classical methods in terms of efficiency and ability to minimize or eliminate the use and generation of harmful substances will promote more efficient use of energy and resources in close association with the principles supporting the concept of green chemistry.
  • 1.4K
  • 10 May 2022
Topic Review
Fine Wine and Gout
From ancient times to the present day, gout has been associated in the popular and scientific literature with wealthy men who overindulge in fancy foods, fine wine, and debauchery. Curiously, amongst diseases, gout was thought to be good, a malady to be accepted because of otherwise beneficial effects on health, and longevity. 
  • 1.4K
  • 13 Jun 2022
Topic Review
Macrophage Polarization in Atherosclerosis
Macrophages (Macs) are one of the major cell types of the innate immune system. They regulate inflammation and clear infection through antigen presentation, polarization, and phagocytosis. Macs release cytokines to regulate other immune cells.
  • 1.4K
  • 24 Jun 2022
Topic Review
New Trends in Aquaculture Feed Production
Fish plays a crucial role in global human nutrition as a source of essential nutrients. Marine-derived ingredients (fishmeal and fish oil) are of critical importance in fish feed production. Fishmeal primarily provides protein for fish growth but is also a valuable source of micro-nutrients such as vitamins, minerals, and lipids. In addition, fishmeal contributes to improved feed digestibility and palatability, particularly in weaning diets for many species. 
  • 1.4K
  • 05 Sep 2022
Topic Review
Sex Differences in Memory
Although there are many physiological and psychological gender differences in humans, memory, in general, is fairly stable across the sexes. By studying the specific instances in which males and females demonstrate differences in memory, we are able to further understand the brain structures and functions associated with memory. It is within specific experimental trials that differences appear, such as methods of recalling past events, explicit facial emotion recognition tasks, and neuroimaging studies regarding size and activation of different brain regions. Research seems to focus especially on gender differences in explicit memory. Like many other nuances of the human psyche, these differences are studied with the goal of lending insight to a greater understanding of the human brain.
  • 1.4K
  • 10 Oct 2022
Topic Review
2015 Cash for Vote Scam
The 2015 cash-for-votes scam was a political scandal, the second scandal of its kind since the 2008 cash-for-votes scandal. The 2015 political scandal started off when the Telugu Desam Party Leaders of Telangana state were caught in a video footage, aired in the media, offering bribes to a nominated MLA for his vote in the 2015 elections of the Telangana Legislative Council. The Telugu Desam MLA Revanth Reddy was arrested by the Telangana Police when he was offering Rs. 50 lakhs to the nominated MLA Elvis Stephenson. Reddy was then presented before the court of justice and sent to jail. Similarly, the phone conversation, which was quoted as the voice of N. Chandrababu Naidu, the Andhra Pradesh Chief Minister, with the same nominated MLA was aired in the news media. The Telugu Desam party alleged that the scandal, was a political vendetta, doctored by the Telangana State Government under the direction of K. Chandrashekhar Rao, the Chief Minister of Telangana, alongside the YSR Congress Party. In a further development, The High Court of Judicature at Hyderabad for the States of Andhra Pradesh, and Telangana, granted bail to Revanth Reddy and two other co-accused due to lack of substantial evidence.
  • 1.4K
  • 18 Oct 2022
Topic Review
HTC Touch Diamond
The HTC Touch Diamond, also known as the HTC P3700 or its codename the HTC Diamond, is a Windows Mobile 6.1-powered Pocket PC designed and manufactured by HTC. It is the first device to feature TouchFLO 3D - a new version of the TouchFLO interface, unique to the Touch family. The HTC Touch Diamond was first available in Hong Kong in late May 2008. It was available across all major European carriers in June 2008, and later in the year in other parts of the world. The United States Touch Diamond was launched on September 14, 2008 on the Sprint network, and April 10, 2009 on the Verizon Wireless network. The European release date was slightly delayed by a last-minute ROM update. The carrier bound names for this phone include T-Mobile MDA Compact IV, O2 XDA Diamond and O2 XDA Ignito. It is the official successor of the HTC Touch. The successor to the Touch Diamond - the HTC Touch Diamond2 - was announced in February 2009 for Q2 2009 release outside the US and Q4 release estimated for North America.
  • 1.4K
  • 19 Oct 2022
Topic Review
Nutrition in Chronic Pain Management
A poor nutritional status such as malnutrition, unhealthy dietary behaviors, and a suboptimal dietary intake can play a significant role in the occurrence, development, and prognosis of chronic pain. The relationship between nutrition and chronic pain is complex and may involve many underlying mechanisms such as oxidative stress, inflammation, and glucose metabolism. As such, pain management requires a comprehensive and interdisciplinary approach that includes nutrition. Nutrition is the top modifiable lifestyle factor for chronic non-communicable diseases including chronic pain.
  • 1.4K
  • 26 Oct 2022
Topic Review
The Wavy Liquid Film
Two-phase annular flow in vertical pipes is one of the most common and important flow regimes in fluid mechanics, particularly in the field of building drainage systems where discharges to the vertical pipe are random and the flow is unsteady. With the development of experimental techniques and analytical methods, the understanding of the fundamental mechanism of the annular two-phase flow has been significantly advanced, such as liquid film development, evolution of the disturbance wave, and droplet entrainment mechanism. 
  • 1.4K
  • 16 Nov 2022
Topic Review
«Hadron-M» Complex Installation
“Hadron-M complex installation”, which included an ionization-neutron calorimeter with an area of 55 m2 and an absorber thickness of 1244 g/cm2 (out of eight rows of ionization chambers), one row of neutron detectors and two shower systems of scintillation detectors. The effective area of the “Hadron-M” complex installation was about 30,000 m2.
  • 1.4K
  • 27 Feb 2023
Topic Review
Campus Energy Management
Energy is very important in daily life. The smart power system provides an energy management system using various techniques. Among other load types, campus microgrids are very important, and they consume large amounts of energy. Energy management systems in campus prosumer microgrids have been addressed in different works.
  • 1.4K
  • 27 Feb 2023
Topic Review
Kappa-2 Carrageenans
Hybrid carrageenans, also called kappa-2 (K2) or weak kappa, are a class of sulfated polysaccharides with thermo-reversible gelling properties in water and are extracted from a specific family of red seaweeds. K2 are known in the industry for their texturizing properties which are intermediate between those of kappa-carrageenans (K) and iota-carrageenans (I). As such, K2 are gaining industrial interest, as they can replace blends of K and I (K + I) in some niche applications. 
  • 1.4K
  • 22 Sep 2023
Topic Review
6G as Support for IoE and Private Networks
The emergence of the sixth generation of cellular systems (6G) signals a transformative era and ecosystem for mobile communications, driven by demands from technologies like the internet of everything (IoE), V2X communications, and factory automation. The primary goals of 6G include providing sophisticated and high-quality services, extremely reliable and further-enhanced mobile broadband (feMBB), low-latency communication (ERLLC), long-distance and high-mobility communications (LDHMC), ultra-massive machine-type communications (umMTC), extremely low-power communications (ELPC), holographic communications, and quality of experience (QoE), grounded in incorporating massive broad-bandwidth machine-type (mBBMT), mobile broad-bandwidth and low-latency (MBBLL), and massive low-latency machine-type (mLLMT) communications.
  • 1.4K
  • 13 Nov 2023
Topic Review
Plastic Mismanagement in Africa
Plastic waste pollution is one of the main items on international agendas. It leads to more and more leakages and constitutes a dangerous threat to living beings and the ecosystem (toxic substances). Globally, only 9% of plastic waste is recycled, while 22% of it is mismanaged. A large part of this waste ends up legally or illegally in Africa.
  • 1.4K
  • 22 Jan 2024
Topic Review
Melatonin in the Epithelial-to-Mesenchymal Transition in Cancer
The epithelial-to-mesenchymal transition (EMT) is a process taking place during carcinogenesis. The phenotypic changes include the acquisition of new properties such as increased motility and polarity, leading to invasiveness and the formation of metastasis and chemo- and radioresistance. During the process, epithelial markers are lost whilst mesenchymal markers are overexpressed. EMT-related transcription factors are induced and multiple signaling pathways are activated. Several microRNAs are altered during the transition. Many of these molecules are regulated by melatonin, the pineal hormone, thus behaving as an inhibitor of the EMT in cancer progression. 
  • 1.4K
  • 12 Mar 2024
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