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HandWiki is the world's largest wiki-style encyclopedia dedicated to science, technology and computing. It allows you to create and edit articles as long as you have external citations and login account. In addition, this is a content management environment that can be used for collaborative editing of original scholarly content, such as books, manuals, monographs and tutorials.

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Benzodiazepine Dependence
Benzodiazepine dependence defines a situation in which one has developed one or more of either tolerance, withdrawal symptoms, drug seeking behaviors, such as continued use despite harmful effects, and maladaptive pattern of substance use, according to the DSM-IV. In the case of benzodiazepine dependence, however, the continued use seems to be associated with the avoidance of unpleasant withdrawal reaction rather than from the pleasurable effects of the drug. Benzodiazepine dependence develops with long-term use, even at low therapeutic doses, without the described dependence behavior. Addiction consists of people misusing or craving the drug not to relieve withdrawal symptoms, but to experience its euphoric or intoxicating effects. It is necessary to distinguish between addiction to and abuse of benzodiazepines and physical dependence on them. The increased GABA inhibition on the neural systems caused by benzodiazepines is counteracted by the body's development of tolerance to the drug's effects; the development of tolerance occurs as a result of neuroadaptations, which result in decreased GABA activity and increased excitability of the glutamate system; these adaptations occur as a result of the body trying to overcome the central nervous system depressant effects of the drug to restore homeostasis. When benzodiazepines are stopped, these neuroadaptations are "unmasked" leading to hyper-excitability of the nervous system and the appearance of withdrawal symptoms. Therapeutic dose dependence is the largest category of people dependent on benzodiazepines. These individuals typically do not escalate their doses to high levels and generally use their medication as intended by their prescriber. Smaller groups include patients escalating their dosage to higher levels and drug misusers as well. Tolerance develops within days or weeks to the anticonvulsant, hypnotic, muscle relaxant and after 4 months there is little evidence that benzodiazepines retain their anxiolytic properties. Some authors, however, disagree and feel that benzodiazepines retain their anxiolytic properties. Long-term benzodiazepine treatment may remain necessary in certain clinical conditions. Numbers of benzodiazepine prescriptions have been declining, due primarily to concerns of dependence. In the short term, benzodiazepines can be effective drugs for acute anxiety or insomnia. With longer-term use, other therapies, both pharmacological and psychotherapeutic, become more effective. This is in part due to the greater effectiveness over time of other forms of therapy, and also due to the eventual development of pharmacological benzodiazepine tolerance.
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  • 18 Nov 2022
Topic Review
Diphyllobothriasis
Diphyllobothriasis is the infection caused by tapeworms of the genus Diphyllobothrium (commonly D. latum and D. nihonkaiense). Diphyllobothriasis mostly occurs in regions where raw fish is regularly consumed; those who consume raw fish are at risk of infection. The infection is often asymptomatic and usually presents only with mild symptoms, which may include gastrointestinal complaints, weight loss, and fatigue. Rarely, vitamin B12 deficiency (possibly leading to anaemia) and gastrointestinal obstructions may occur. Infection may be long-lasting in absence of treatment. Diphyllobothriasis is generally diagnosed by looking for eggs or tapeworm segments in passed stool. Treatment with antiparasitic medications is straightforward, effective, and safe.
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  • 18 Nov 2022
Topic Review
Planck Length
In physics, the Planck length, denoted ℓP, is a unit of length in the system of Planck units that was originally proposed by physicist Max Planck, equal to 1.616255(18)×10−35 m.[note 1] The Planck length can be defined from three fundamental physical constants: the speed of light, the Planck constant, and the gravitational constant. It is also the reduced Compton wavelength of a particle with Planck mass. Regardless of whether it represents some fundamental limit to the universe, it is a useful unit in theoretical physics.
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  • 18 Nov 2022
Topic Review
List of Thor and Delta Launches (1970–79)
Between 1970 and 1979, there were 117 Thor missiles launched, of which 108 were successful, giving a 92.3% success rate. NASA used it to launch its own satellites, as well as to launch satellites for foreign governments and companies.
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Topic Review
Shift (Command)
This article presents a list of commands used by DOS operating systems, especially as used on x86-based IBM PC compatibles (PCs). Other DOS operating systems are not part of the scope of this list. In DOS, many standard system commands were provided for common tasks such as listing files on a disk or moving files. Some commands were built into the command interpreter, others existed as external commands on disk. Over the several generations of DOS, commands were added for the additional functions of the operating system. In the current Microsoft Windows operating system, a text-mode command prompt window, cmd.exe, can still be used.
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Topic Review
Grandfather Paradox
The grandfather paradox is a paradox of time travel in which inconsistencies emerge through changing the past. The name comes from the paradox's description: a person travels to the past and kills their own grandfather before the conception of their father or mother, which prevents the time traveller's existence. Despite its title, the grandfather paradox does not exclusively regard the contradiction of killing one's own grandfather to prevent one's birth. Rather, the paradox regards any action that alters the past, since there is a contradiction whenever the past becomes different from the way it was.
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  • 18 Nov 2022
Topic Review
Fluid and Crystallized Intelligence
The concepts of fluid intelligence (gf) and crystallized intelligence (gc) were introduced in 1963 by the psychologist Raymond Cattell. According to Cattell's psychometrically-based theory, general intelligence (g) is subdivided into gf and gc. Fluid intelligence is the ability to solve novel reasoning problems and is correlated with a number of important skills such as comprehension, problem solving, and learning. Crystallized intelligence, on the other hand, involves the ability to deduce secondary relational abstractions by applying previously learned primary relational abstractions.
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  • 18 Nov 2022
Topic Review
Keloid
Keloid, also known as keloid disorder and keloidal scar, is the formation of a type of scar which, depending on its maturity, is composed mainly of either type III (early) or type I (late) collagen. It is a result of an overgrowth of granulation tissue (collagen type 3) at the site of a healed skin injury which is then slowly replaced by collagen type 1. Keloids are firm, rubbery lesions or shiny, fibrous nodules, and can vary from pink to the color of the person's skin or red to dark brown in color. A keloid scar is benign and not contagious, but sometimes accompanied by severe itchiness, pain, and changes in texture. In severe cases, it can affect movement of skin. Worldwide, men and women of African, Asian, Hispanic and European descent can develop these raised scars. In the United States keloid scars are seen 15 times more frequently in people of sub-Saharan African descent than in people of European descent. There is a higher tendency to develop a keloid among those with a family history of keloids and people between the ages of 10 and 30 years. Keloids should not be confused with hypertrophic scars, which are raised scars that do not grow beyond the boundaries of the original wound.
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  • 18 Nov 2022
Topic Review
Short Chronology
The short chronology is one of the chronologies of the Near Eastern Bronze and Early Iron Age, which fixes the reign of Hammurabi to 1728–1686 BC and the sack of Babylon to 1531 BC. The absolute 2nd millennium BC dates resulting from these reference points have very little academic support, and have essentially been disproved by recent dendrochronology research. The middle chronology (reign of Hammurabi 1792–1750 BC) is more commonly accepted in academic literature. For much of the period in question, middle chronology dates can be calculated by adding 64 years to the corresponding short chronology date (e.g. 1728 BC in short chronology corresponds to 1792 in middle chronology). After the so-called "dark age" between the fall of Babylon and the rise of the Kassite dynasty in Babylonia, absolute dating becomes less uncertain. While exact dates are still not agreed upon, the 64-year middle/short chronology gap ceases from the beginning of the Third Babylon Dynasty onward.
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  • 18 Nov 2022
Topic Review
August 2013 NASDAQ Flash Freeze
For three hours on August 22, 2013, trading was halted on the Nasdaq Stock Market. Trading on the exchange stopped at 12:14pm and resumed at 3:25pm, with 35 minutes left of trading for the day. One week after the trading halt NASDAQ OMX credited the freeze to an overloading of the Securities Information Processor (SIP) caused by reconnection issues with the New York Stock Exchange Arca. The freeze received substantial media coverage and generated discussions on the security of increasingly technologically advanced stock exchanges. The event coined the term "flash freeze" following the earlier "flash crash" on May 6, 2010. Throughout the freeze the Nasdaq composite remained at 3631.17. Following the reopening of the market it rose, closing at 3,638.71, 1.1% higher. Shares of the Nasdaq exchange closed 3.42% down following the freeze.
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  • 18 Nov 2022
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