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HandWiki. Keloid. Encyclopedia. Available online: https://encyclopedia.pub/entry/35197 (accessed on 25 September 2026).
HandWiki. Keloid. Encyclopedia. Available at: https://encyclopedia.pub/entry/35197. Accessed September 25, 2026.
HandWiki. "Keloid" Encyclopedia, https://encyclopedia.pub/entry/35197 (accessed September 25, 2026).
HandWiki. (2022, November 18). Keloid. In Encyclopedia. https://encyclopedia.pub/entry/35197
HandWiki. "Keloid." Encyclopedia. Web. 18 November, 2022.
Keloid
Edit
The content is sourced from: https://handwiki.org/wiki/Medicine:Keloid

Keloid, also known as keloid disorder and keloidal scar, is the formation of a type of scar which, depending on its maturity, is composed mainly of either type III (early) or type I (late) collagen. It is a result of an overgrowth of granulation tissue (collagen type 3) at the site of a healed skin injury which is then slowly replaced by collagen type 1. Keloids are firm, rubbery lesions or shiny, fibrous nodules, and can vary from pink to the color of the person's skin or red to dark brown in color. A keloid scar is benign and not contagious, but sometimes accompanied by severe itchiness, pain, and changes in texture. In severe cases, it can affect movement of skin. Worldwide, men and women of African, Asian, Hispanic and European descent can develop these raised scars. In the United States keloid scars are seen 15 times more frequently in people of sub-Saharan African descent than in people of European descent. There is a higher tendency to develop a keloid among those with a family history of keloids and people between the ages of 10 and 30 years. Keloids should not be confused with hypertrophic scars, which are raised scars that do not grow beyond the boundaries of the original wound.

keloid scar keloid scars collagen

References

  1. Babu, M; Meenakshi, J; Jayaraman, V; Ramakrishnan, KM (2005). "Keloids and hypertrophic scars: A review". Indian Journal of Plastic Surgery 38 (2): 175–9. doi:10.4103/0970-0358.19796.  https://dx.doi.org/10.4103%2F0970-0358.19796
  2. "Keloid Scar: Find Causes, Symptoms, and Removal". http://www.medicinenet.com/keloid/article.htm. 
  3. Arredondo Montero, Javier; Bronte Anaut, Mónica; Bardaji Pascual, Carlos. "Extensive Keloid and Hypertrophic Mixed Scarring Pattern in Ear Lobes of a 14-Year-Old African Female: A Case Report". Fetal and Pediatric Pathology. doi:10.1080/15513815.2022.2080310. PMID 35620898.  https://dx.doi.org/10.1080%2F15513815.2022.2080310
  4. Andrews, Jonathan P.; Marttala, Jaana; MacArak, Edward; Rosenbloom, Joel; Uitto, Jouni (2016). "Keloids: The paradigm of skin fibrosis — Pathomechanisms and treatment". Matrix Biology 51: 37–46. doi:10.1016/j.matbio.2016.01.013. PMID 26844756.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4842154
  5. Kiprono, S.K.; Chaula, B.M.; Masenga, J.E.; Muchunu, J.W.; Mavura, D.R.; Moehrle, M. (September 2015). "Epidemiology of keloids in normally pigmented Africans and African people with albinism: population-based cross-sectional survey" (in en). British Journal of Dermatology 173 (3): 852–854. doi:10.1111/bjd.13826. PMID 25833201. http://doi.wiley.com/10.1111/bjd.13826. 
  6. https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001852/
  7. Ramakrishnan, K. M.; Thomas, K. P.; Sundararajan, C. R. (1974). "Study of 1,000 patients with keloids in South India". Plastic and Reconstructive Surgery 53 (3): 276–80. doi:10.1097/00006534-197403000-00004. PMID 4813760.  https://dx.doi.org/10.1097%2F00006534-197403000-00004
  8. Wound Healing, Keloids at eMedicine https://emedicine.medscape.com/article/1298013-overview
  9. Gauglitz, Gerd; Korting, Hans (2011). "Hypertrophic scarring and keloids: Pathomechanisms and current and emerging treatment strategies". Molecular Medicine 17 (1–2): 113–25. doi:10.2119/molmed.2009.00153. PMID 20927486.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3022978
  10. Arno, Anna I.; Gauglitz, Gerd G.; Barret, Juan P.; Jeschke, Marc G. (2014). "Up-to-date approach to manage keloids and hypertrophic scars: A useful guide". Burns 40 (7): 1255–66. doi:10.1016/j.burns.2014.02.011. PMID 24767715.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4186912
  11. Zouboulis, C. C.; Blume, U.; Büttner, P.; Orfanos, C. E. (September 1993). "Outcomes of cryosurgery in keloids and hypertrophic scars. A prospective consecutive trial of case series". Archives of Dermatology 129 (9): 1146–1151. doi:10.1001/archderm.1993.01680300074011. ISSN 0003-987X. PMID 8363398. https://pubmed.ncbi.nlm.nih.gov/8363398/. 
  12. "Keloid Research Foundation". 2016-11-07. http://www.keloidresearchfoundation.org/treatment-options.php. 
  13. Griffith, B. H. (1966). "The treatment of keloids with triamcinolone acetonide". Plastic and Reconstructive Surgery 38 (3): 202–8. doi:10.1097/00006534-196609000-00004. PMID 5919603.  https://dx.doi.org/10.1097%2F00006534-196609000-00004
  14. "Keloid Treatment". https://www.txid.org/?page_id=4043. 
  15. Leszczynski, Rafael; da Silva, Carolina AP; Pinto, Ana Carolina Pereira Nunes; Kuczynski, Uliana; da Silva, Edina MK (2022-09-26). Cochrane Wounds Group. ed. "Laser therapy for treating hypertrophic and keloid scars" (in en). Cochrane Database of Systematic Reviews 2022 (9). doi:10.1002/14651858.CD011642.pub2. PMC 9511989. http://doi.wiley.com/10.1002/14651858.CD011642.pub2. 
  16. Halim, Ahmad Sukari; Emami, Azadeh; Salahshourifar, Iman; Kannan, Thirumulu Ponnuraj (2012). "Keloid Scarring: Understanding the Genetic Basis, Advances, and Prospects". Archives of Plastic Surgery 39 (3): 184–9. doi:10.5999/aps.2012.39.3.184. PMID 22783524.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3385329
  17. Marneros, Alexander G.; Norris, James E. C.; Olsen, Bjorn R.; Reichenberger, Ernst (2001). "Clinical Genetics of Familial Keloids". Archives of Dermatology 137 (11): 1429–34. doi:10.1001/archderm.137.11.1429. PMID 11708945.  https://dx.doi.org/10.1001%2Farchderm.137.11.1429
  18. Bloom, D (1956). "Heredity of keloids; review of the literature and report of a family with multiple keloids in five generations". New York State Journal of Medicine 56 (4): 511–9. PMID 13288798.  http://www.ncbi.nlm.nih.gov/pubmed/13288798
  19. "Therapy of auricular keloids: review of different treatment modalities and proposal for a therapeutic algorithm". Eur Arch Otorhinolaryngol 264 (12): 1497–508. December 2007. doi:10.1007/s00405-007-0383-0. PMID 17628822.  https://dx.doi.org/10.1007%2Fs00405-007-0383-0
  20. Gauglitz, Gerd; Korting, Hans; Pavicic, T; Ruzicka, T; Jeschke, M. G. (2011). "Hypertrophic scarring and keloids: Pathomechanisms and current and emerging treatment strategies". Molecular Medicine 17 (1–2): 113–25. doi:10.2119/molmed.2009.00153. PMID 20927486.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3022978
  21. Gauglitz, Gerd G.; Korting, Hans C.; Pavicic, Tatiana; Ruzicka, Thomas; Jeschke, Marc G. (2010-10-05). "Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies". Molecular Medicine (Springer Science and Business Media LLC) 17 (1–2): 113–125. doi:10.2119/molmed.2009.00153. ISSN 1076-1551. PMID 20927486.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3022978
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