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Oprelvekin
Oprelvekin is recombinant interleukin eleven (IL-11), a thrombopoietic growth factor that directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. It is marketed under the trade name Neumega.
  • 643
  • 18 Nov 2022
Topic Review
Fiat CR.42
The Fiat CR.42 Falco ("Falcon", plural: Falchi) was a single-seat sesquiplane fighter developed and produced by Italian aircraft manufacturer Fiat Aviazione. It served primarily in Italy's Regia Aeronautica both before and during the Second World War. The CR.42 was an evolutionary design of Fiat’s earlier CR.32 fighter, featuring a more powerful supercharged Fiat A.74R1C.38 air-cooled radial engine and aerodynamic improvements to its relatively clean exterior surfaces. The aircraft proved to be relatively agile in flight, a factor that had been attributed to its very low wing loading and a sometimes decisive tactical advantage. RAF Intelligence praised its exceptional maneuverability, further noting that "the plane was immensely strong", though it was technically outclassed by faster, more heavily armed monoplanes. While primarily used as a fighter, various other roles were adopted for some variants of the type, such as the CR.42CN dedicated night fighter model, the CR.42AS ground attack aircraft, and the CR.42B Biposto twin-seat trainer aircraft. During May 1939, the CR.42 entered service with the Regia Aeronautica; it was the last of the Fiat biplane fighters to enter front line service. By 10 June 1940, the date when Italy entered the Second World War, roughly 300 of the type had been delivered, which were initially tasked with defending Italy's cities and key military installations. By the end of 1940, the Falco had been involved in combat on various fronts, including the Battle of France, the Battle of Britain, Malta, North Africa, and Greece. By the end of the war, Italian CR.42s had been used on further fronts, including Iraq, the Eastern Front and the Italian mainland. Following the signing of the Italian armistice with the Allies on 8 September 1943, the type was primarily relegated to use as a trainer by the Italian Co-Belligerent Air Force , while some Italian CR.42s were seized by the Germans and used by the Luftwaffe to perform ground attack missions. In addition to its service in Italy, the CR.42 was produced and entered service in smaller numbers with the air forces of several nations, including Belgium, Sweden and Hungary. By the end of production, in excess of 1,800 CR.42s has been constructed, making it the most numerous Italian aircraft to be used during the Second World War. Aviation author Przemyslaw Skulski has claimed that the fighter had performed at its best during its service with the Hungarian Air Force, specifically during its deployment against Soviet forces on the Eastern Front of the war, where it reportedly achieved a kill to loss ratio of 12 to 1.
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  • 18 Nov 2022
Topic Review
Range Anxiety
Range anxiety is the fear that a vehicle has insufficient range to reach its destination and would thus strand the vehicle's occupants. The term, which is primarily used in reference to battery electric vehicles (BEVs), is considered to be one of the major barriers to large-scale adoption of all-electric cars. The term range anxiety was first reported in the press on September 1, 1997, in the San Diego Business Journal by Richard Acello referring to worries of GM EV1 electric car drivers. On July 6, 2010, General Motors filed to trademark the term, stating it was for the purpose of "promoting public awareness of electric vehicle capabilities". The Norwegian equivalent rekkeviddeangst was assigned second place in a list of Norwegian "words of the year" for 2013 by the Norwegian Language Council. The main strategies to alleviate range anxiety among electric car drivers are the deployment of extensive charging infrastructure, the development of higher battery capacity at a cost-effective price, battery swapping technology, use of range extenders, accurate navigation and range prediction and availability of free loan vehicles for long trips. According to a study by the American Automobile Association, the cure to range anxiety is owning an electric vehicle.
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  • 18 Nov 2022
Topic Review
Cyrillic Script
The Cyrillic script (/sɪˈrɪlɪk/ sə-RIL-ik) is a writing system used for various languages across Eurasia and is used as the national script in various Slavic, Turkic, Mongolic, Uralic, Caucasian and Iranic-speaking countries in Southeastern Europe, Eastern Europe, the Caucasus, Central Asia, North Asia and East Asia. (As of 2019), around 250 million people in Eurasia use Cyrillic as the official script for their national languages, with Russia accounting for about half of them. With the accession of Bulgaria to the European Union on 1 January 2007, Cyrillic became the third official script of the European Union, following the Latin and Greek alphabets. In the 9th century AD, the Bulgarian tsar Simeon I the Great – following the cultural and political course of his father Boris I – commissioned a new script, the Early Cyrillic alphabet, to be made at the Preslav Literary School in the First Bulgarian Empire, which would replace the Glagolitic script, produced earlier by Saints Cyril and Methodius and the same disciples that created the new Slavic script in Bulgaria. The usage of the Cyrillic script in Bulgaria was made official in 893. The new script became the basis of alphabets used in various languages, especially those of Orthodox Slavic origin, and non-Slavic languages influenced by Bulgarian. For centuries Cyrillic was used by Catholic and Muslim Slavs too (see Bosnian Cyrillic). Cyrillic is derived from the Greek uncial script, augmented by letters from the older Glagolitic alphabet, including some ligatures. These additional letters were used for Old Church Slavonic sounds not found in Greek. The script is named in honor of the Saint Cyril, one of the two Byzantine brothers, Saints Cyril and Methodius, who created the Glagolitic alphabet earlier on. Modern scholars believe that Cyrillic was developed and formalized by the early disciples of Cyril and Methodius in the Preslav Literary School, the most important early literary and cultural centre of the First Bulgarian Empire and of all Slavs. The school developed the Cyrillic script: The earliest datable Cyrillic inscriptions have been found in the area of Preslav. They have been found in the medieval city itself, and at nearby Patleina Monastery, both in present-day Shumen Province, in the Ravna Monastery and in the Varna Monastery. With the orthographic reform of Saint Evtimiy of Tarnovo and other prominent representatives of the Tarnovo Literary School (14th and 15th centuries) such as Gregory Tsamblak or Constantine of Kostenets the school influenced Russian, Serbian, Wallachian and Moldavian medieval culture. That is famous in Russia as the second South-Slavic influence. In the early 18th century, the Cyrillic script used in Russia was heavily reformed by Peter the Great, who had recently returned from his Grand Embassy in Western Europe. The new letterforms, called the Civil script, became closer to those of the Latin alphabet; several archaic letters were abolished and several letters were designed by Peter himself. Letters became distinguished between upper and lower case. West European typography culture was also adopted. The pre-reform forms of letters called 'Полуустав' were notably kept for use in Church Slavonic and are sometimes used in Russian even today, especially if one wants to give a text a 'Slavic' or 'archaic' feel.
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  • 22 Nov 2022
Topic Review
Methods Used to Study Memory
The study of memory incorporates research methodologies from neuropsychology, human development and animal testing using a wide range of species. The complex phenomenon of memory is explored by combining evidence from many areas of research. New technologies, experimental methods and animal experimentation have led to an increased understanding of the workings of memory.
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  • 18 Nov 2022
Topic Review
Customer-Relationship Management
Customer-relationship management (CRM) is an approach to manage a company's interaction with current and potential customers. It uses data analysis about customers' history with a company to improve business relationships with customers, specifically focusing on customer retention and ultimately driving sales growth. One important aspect of the CRM approach is the systems of CRM that compile data from a range of different communication channels, including a company's website, telephone, email, live chat, marketing materials and more recently, social media. Through the CRM approach and the systems used to facilitate it, businesses learn more about their target audiences and how to best cater to their needs.
  • 4.0K
  • 22 Nov 2022
Topic Review
Resilience in the Built Environment
Resilience in the Built Environment is the built environment's capability to keep adapting to existing and emerging threats such as severe wind storms or earthquakes and creating robustness and redundancy in building design. New implications of changing conditions on the efficiency of different approaches to design and planning can be addressed in the following term.
  • 1.4K
  • 18 Nov 2022
Topic Review
Bilayer Graphene
Bilayer graphene is a material consisting of two layers of graphene. One of the first reports of bilayer graphene was in the seminal 2004 Science paper by Geim and colleagues, in which they described devices "which contained just one, two, or three atomic layers"
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  • 18 Nov 2022
Topic Review
Tupaia (Genus)
Tupaia is a treeshrew genus in the family Tupaiidae that was first described by Thomas Stamford Raffles in 1821. The name of this genus derives from the Malay word tupai meaning squirrel or small animal resembling a squirrel.
  • 1.4K
  • 18 Nov 2022
Topic Review
Tensor Processing Unit
A tensor processing unit (TPU) is an AI accelerator application-specific integrated circuit (ASIC) developed by Google specifically for neural network machine learning, particularly using Google's own TensorFlow software. Google began using TPUs internally in 2015, and in 2018 made them available for third party use, both as part of its cloud infrastructure and by offering a smaller version of the chip for sale.
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  • 18 Nov 2022
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