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Biography
Elena Filonova
https://urfu.ru/ru/about/personal-pages/personal/person/elena.filonova/ https://science.urfu.ru/portal/ru/persons/--(effc56a3-2f6c-4140-8dc6-8797bdd43528).html https://www.scopus.com/authid/detail.uri?authorId=6602857032 https://scholar.google.com/citations?user=1LIaseoAAAAJ&hl=ru https://www.researchgate.net/profile/E-Filonova https://orcid.org/0000-0002-7273-7525 https://www.webofscience
  • 405
  • 01 Oct 2023
Topic Review
Cerebral Vasomotor Reactivity in COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily affects the respiratory system but can also lead to neurological complications. Among COVID-19 patients, the endothelium is considered the Achilles heel. A variety of endothelial dysfunctions may result from SARS-CoV-2 infection and subsequent endotheliitis, such as altered vascular tone, oxidative stress, and cytokine storms. The cerebral hemodynamic impairment that is caused is associated with a higher probability of severe disease and poor outcomes in patients with COVID-19.
  • 48
  • 01 Oct 2023
Topic Review
Zirconium Carbide for Hypersonic Applications
At ultra-high temperatures, resilient, durable, stable material choices are limited. While Carbon/Carbon (C/C) composites (carbon fibers and carbon matrix phases) are the materials of choice, zirconium carbide (ZrC) provides an option in hypersonic environments and specifically in wing leading edge (WLE) applications. 
  • 25
  • 30 Sep 2023
Topic Review
Motivational Patterns and Personal Characteristics of Carsharing Users
In the last decade, in Europe and the US, carsharing has become a mainstream transportation mode offering a sustainable solution to serious urban problems such as pollution, economic crisis, congestion, and parking. In Greece, carsharing is currently entering its commercial phase. Planners and providers strive to gain an insight into the factors influencing the use of carsharing to effectively implement carsharing systems (CSS). In this context, understanding the motives and usage conditions are considered necessary. Based on a qualitative analysis (semi-constructed interviews, n = 52), this paper identifies motivational patterns as well as personal characteristics of potential users that can be further explored through quantitative research methods. During the data analysis process, participants’ responses were classified into categories that revealed not only the factors that motivated them but also unveiled the challenges they face when utilizing carsharing schemes. These factors were the following: familiarity, comfort, mindset, everyday life, usability, and economy. Next, these factors were analyzed further based on the personal characteristics of the respondents preparing the ground for quantitative research in future research initiatives. Notably, the present findings could be beneficial to operators, policymakers, and stakeholders endeavoring to appraise shared mobility schemes in Greece and Mediterranean countries in general.
  • 28
  • 30 Sep 2023
Topic Review
Metastatic Spinal Cord Compression in Secondary Care
Metastatic spinal cord compression (MSCC) represents an oncological emergency and clinicians should be aware of the potential long-term neurological impact. Urgent diagnosis and treatment is still challenging. Magnetic resonance imaging (MRI) of the whole spine is the imaging method of choice that should be carried out within 24 h of clinical suspicion. Steroid therapy is administered immediately after the establishment of diagnosis, followed by definitive treatment, which may include any combination of surgery and/or radiotherapy (RT). Treatment should ideally be initiated within 24 h of the confirmed MSCC. Trainees require further teaching to improve their knowledge. Equally, oncological patients should be aware of the signs and symptoms of MSCC in order to optimise early detection.
  • 38
  • 30 Sep 2023
Topic Review
Exosomes in the Renal Cell Cancer
Renal cell carcinoma (RCC) is the most prevalent type of kidney cancer originating from renal tubular epithelial cells, with clear cell RCC comprising approximately 80% of cases. The primary treatment modalities for RCC are surgery and targeted therapy, albeit with suboptimal efficacies. Despite progress in RCC research, significant challenges persist, including advanced distant metastasis, delayed diagnosis, and drug resistance. Growing evidence suggests that extracellular vesicles (EVs) play a pivotal role in multiple aspects of RCC, including tumorigenesis, metastasis, immune evasion, and drug response. These membrane-bound vesicles are released into the extracellular environment by nearly all cell types and are capable of transferring various bioactive molecules, including RNA, DNA, proteins, and lipids, aiding intercellular communication. The molecular cargo carried by EVs renders them an attractive resource for biomarker identification, while their multifarious role in the RCC offers opportunities for diagnosis and targeted interventions, including EV-based therapies. As the most versatile type of EVs, exosomes have attracted much attention as nanocarriers of biologicals, with multi-range signaling effects. Despite the growing interest in exosomes, there is currently no widely accepted consensus on their subtypes and properties. The emerging heterogeneity of exosomes presents both methodological challenges and exciting opportunities for diagnostic and clinical interventions.
  • 25
  • 30 Sep 2023
Topic Review
Adoptive T-cell therapy for metastatic melanoma
Adoptive T cell therapy (ACT) is a fast developing, niche area of immunotherapy (IO), which is revolutionising the therapeutic landscape of solid tumour oncology, especially metastatic melanoma (MM). Identifying tumour antigens (TAs) as potential targets, the ACT response is mediated by either Tumour Infiltrating Lymphocytes (TILs) or genetically modified T cells with specific receptors – T cell receptors (TCRs) or chimeric antigen receptors (CARs) or more prospectively, natural killer (NK) cells.
  • 26
  • 30 Sep 2023
Topic Review
Asthma Endotypes and Phenotypes
Asthma is considered an umbrella diagnosis comprising various distinct manifestations and mechanisms. The precise definition of these endotypes and subgroups is crucial for asthma management due to therapeutic and prognostic implications.  A reductionist research approach to asthma complexity may explain the lack of translation of genomic findings into clinical practice to date, despite the abundance of low-to-modest effect genetic loci revealed by genomic studies of asthma. Shifting asthma diagnosis to specific endotypes and phenotypes  may provide insights into features that can be prevented or alleviated by therapeutic intervention.
  • 31
  • 29 Sep 2023
Topic Review
Piezo-Photocatalysis
Piezocatalysis is a technique that relies on the conversion of mechanical energy to trigger chemical reactions that can be utilized to catalyze the degradation of pollutants in water. By combining piezoelectric materials with photocatalytic materials, the built-in electric field generated by the piezoelectric effect promotes the separation and migration of photogenerated carriers, thereby enhancing the efficiency, selectivity, and stability of photocatalytic reactions.
  • 40
  • 29 Sep 2023
Topic Review
Predictive biomarkers for immunotherapy in urothelial cancer
Immune checkpoint inhibitors (ICIs) are commonly used to treat patients with advanced urothelial cancer (UC). However, a significant number of patients do not respond to ICI, and the lack of validated predictive biomarkers impedes the success of the ICI strategy alone or in combination with chemotherapy or targeted therapies. In addition, some patients experience potentially severe adverse events with limited clinical benefit. Therefore, identifying biomarkers of response to ICI is crucial to guide treatment decisions. The most evaluated biomarkers to date are programmed death ligand 1 expression, microsatellite instability/defective mismatch repair phenotype, and tumor mutational burden. Other emerging biomarkers, such as circulating tumor DNA and microbiota, require evaluation in clinical trials.
  • 35
  • 29 Sep 2023
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