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Topic Review
A Personalized Longitudinal Strategy in Low-Grade Glioma Patients
Diffuse low-grade glioma (LGG) is a rare cerebral cancer, mostly involving young adults with an active life at diagnosis. If left untreated, LGG widely invades the brain and becomes malignant, generating neurological worsening and ultimately death. Early and repeat treatments for this incurable tumor, including maximal connectome-based surgical resection(s) in awake patients, enable postponement of malignant transformation while preserving quality of life owing to constant neural network reconfiguration. Due to considerable interindividual variability in terms of LGG course and consecutive cerebral reorganization, a multistage longitudinal strategy should be tailored accordingly in each patient. It is crucial to predict how the glioma will progress (changes in growth rate and pattern of migration, genetic mutation, etc.) and how the brain will adapt (changes in patterns of spatiotemporal redistribution, possible functional consequences such as epilepsy or cognitive decline, etc.). The goal is to anticipate therapeutic management, remaining one step ahead in order to select the optimal (re-)treatment(s) (some of them possibly kept in reserve), at the appropriate time(s) in the evolution of this chronic disease, before malignization and clinical worsening.
  • 362
  • 13 Oct 2022
Topic Review
A Polyherbal Mixture with Nutraceutical Properties for Ruminants
BioCholine Powder is a polyherbal feed additive composed of Achyrantes aspera, Trachyspermum ammi, Azadirachta indica, and Citrullus colocynthis. 
  • 129
  • 28 Feb 2024
Topic Review
A Practical Teaching Course of Protein Engineering
Proteins are the workhorses of the cell. With different combinations of the 20 common amino acids and some modifications of these amino acids, proteins have evolved with a staggering array of new functions and capabilities due to Protein Engineering techniques. The practical course presented was offered to undergraduate bioengineering and chemical students at the Faculty of Engineering of the University of Porto (Portugal) and consists of sequential laboratory sessions to learn the basic skills related to the expression and purification of recombinant proteins in bacterial hosts. These experiments were successfully applied by students as all working groups were able to isolate a model recombinant protein (the enhanced green fluorescent protein, eGFP) from a cell lysate containing a mixture of proteins and other biomolecules produced by an Escherichia coli strain and evaluate the performance of the extraction and purification procedures they learned.
  • 916
  • 05 May 2022
Topic Review
A Primer for Design and Systems Thinkers
Teaching students to think in complex systems and design is presumably intricate, creative, and nonlinear. However, due to the overwhelming number of standardized tools and frameworks, the process sometimes ends up being procedural and deductive. Conformity to rigid procedures loses the intention of creative problem-solving towards tackling wicked problems.
  • 454
  • 25 Jan 2024
Topic Review
A Proactive Protection by Computational Intelligence Methods
A combination of computational intelligence methods: identifying anomalies in network traffic by evaluating its self-similarity, detecting and classifying cyberattacks in anomalies, and taking effective protection measures using Long Short-Term Memory (LSTM) and Gated Recurrent Unit (GRU) cells.
  • 382
  • 25 Oct 2022
Topic Review Peer Reviewed
A Process Synthesis and Intensification Framework
This Process Synthesis and Intensification (PS+I) framework uses a low-aggregation superstructure to solve the synthesis problem, and its solution is interpreted and translated into a task-integrated intensified process. Then, the process is post-optimized to find a better balance between operation and equipment costs. The solution leads to novel and counterintuitive intensified processes with low cost and energy requirements.
  • 347
  • 24 Jul 2024
Topic Review
A Product/Service System
Product/service system (PSS) is widely considered as a promising design object with the potential to enhance environmental sustainability of industrial solutions. The state of the art of PSS design research includes several prescriptive PSS design support tools, methods and procedures. This body of literature has been extensively reviewed in the past. However, there is a lack of consolidation of the available prescriptive knowledge in a condensed and practically useful format that can be used by practitioners to guide their conceptual PSS design activities and by researchers to build their work on. Thus, to address this gap in our knowledge, we use an intra-disciplinary literature analysis and meta-synthesis approach to consolidate the extant prescriptive PSS design knowledge in the form of a schema for conceptual PSS design.
  • 1.2K
  • 29 Oct 2020
Topic Review
A PRoliferation-Inducing Ligand in IgA Nephropathy Pathogenesis
A PRoliferation-Inducing Ligand (APRIL), the thirteenth member of the tumor necrosis factor superfamily, plays a key role in the regulation of activated B cells, the survival of long-lived plasma cells, and immunoglobulin (Ig) isotype class switching. Several lines of evidence have implicated APRIL in the pathogenesis of IgA nephropathy (IgAN).
  • 186
  • 10 Nov 2023
Topic Review
A Promiscuous Bacterial P450
CYP102A1 (BM3) is a catalytically self-sufficient flavocytochrome fusion protein isolated from Bacillus megaterium, which displays similar metabolic capabilities to many drug-metabolizing human P450 isoforms. BM3′s high catalytic efficiency, ease of production and malleable active site makes the enzyme a desirable tool in the production of small molecule metabolites, especially for compounds that exhibit drug-like chemical properties. The engineering of select key residues within the BM3 active site vastly expands the catalytic repertoire, generating variants which can perform a range of modifications. This provides an attractive alternative route to the production of valuable compounds that are often laborious to synthesize via traditional organic means. 
  • 465
  • 03 Nov 2021
Topic Review
A Promising Downsampling Alternative in a Neural Network
Downsampling, which aims to improve computational efficiency by reducing the spatial resolution of feature maps, is a critical operation in neural networks. Upsampling also plays an important role in neural networks. It is often used for image super-resolution, segmentation, and generation tasks via the reconstruction of high-resolution feature maps during the decoding stage in the neural network.
  • 316
  • 04 Dec 2023
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