Topic Review
The Composition and Structure of Silk Fibroin
Silk fibroin is the principal component of raw silk and represents an extensively studied and utilized biopolymer. Silk fibroin is composed by three chains, light, heavy, and P25 protein. Heavy chain is rigorously organized in redundant aminoacidic sequences rich in glycine and alanine, secondary structure is organized in anti-parallel β-sheets that in turn form β-crystallites stacked in nano-fibrils. Those peculiar fibroin’s structural and compositional elements are crucial to determine the excellent physical properties, such as strength and toughness. Besides these characteristics, the processability and biocompatibility have attracted significant attention for the fabrication of several biomaterials suitable in many fields of application.
  • 565
  • 20 Mar 2024
Topic Review
Synthetic Datasets
With the consistent growth in the importance of machine learning and big data analysis, feature selection stands to be one of the most relevant techniques in the field. Extending into many disciplines, the use of feature selection in medical applications, cybersecurity, DNA micro-array data, and many more areas is witnessed. Machine learning models can significantly benefit from the accurate selection of feature subsets to increase the speed of learning and also to generalize the results. Feature selection can considerably simplify a dataset, such that the training models using the dataset can be “faster” and can reduce overfitting. Synthetic datasets were presented as a valuable benchmarking technique for the evaluation of feature selection algorithms.
  • 176
  • 20 Mar 2024
Topic Review Peer Reviewed
Techniques for Theoretical Prediction of Immunogenic Peptides
Small peptides are an important component of the vertebrate immune system. They are important molecules for distinguishing proteins that originate in the host from proteins derived from a pathogenic organism, such as a virus or bacterium. Consequently, these peptides are central for the vertebrate host response to intracellular and extracellular pathogens. Computational models for prediction of these peptides have been based on a narrow sample of data with an emphasis on the position and chemical properties of the amino acids. In past literature, this approach has resulted in higher predictability than models that rely on the geometrical arrangement of atoms. However, protein structure data from experiment and theory are a source for building models at scale, and, therefore, knowledge on the role of small peptides and their immunogenicity in the vertebrate immune system. The following sections introduce procedures that contribute to theoretical prediction of peptides and their role in immunogenicity. Lastly, deep learning is discussed as it applies to immunogenetics and the acceleration of knowledge by a capability for modeling the complexity of natural phenomena.
  • 399
  • 20 Mar 2024
Topic Review
Stablecoins
A stablecoin is a digital currency issued by a private company or financial institution, with its value pegged to a fiat currency, basket of fiat currencies, or commodity, such as gold. Because this paper considers only stablecoins pegged to fiat currencies, such as the U.S. dollar or euro, we use “fsCOIN,” as our abbreviation for a “fiat-currency-denominated stablecoin”.
  • 239
  • 20 Mar 2024
Topic Review
Oligonucleotide-Based Biosensors in Early Diagnosis of Gastric Cancer
Gastric cancer (GC) remains a significant global health challenge, with late-stage diagnosis impacting treatment options and decreased survival rates. To address this, there has been a growing interest in the development of innovative screening and diagnostic methods. Nanobiosensors have undergone multiple iterations and unveiled remarkable features that pledge to reshape patient care. 
  • 196
  • 20 Mar 2024
Topic Review
Importance of Destination Attributes of Sustainable Urban Waterfronts
The waterfront area refers to the region in a town or city that borders a body of water, emphasizing the relationship between land and water. Destination attributes were grouped into two types: sustainable landscapes (aesthetics, water resource rehabilitation, sustainable lighting, emotional experiences, and low-impact development waterfronts) and sustainable recreational spaces (leisure activities, festivals, inclusive destinations, photography, and tourist experiences). Two destination attributes common to-- both types were identified: nightscapes and waterfronts. 
  • 302
  • 20 Mar 2024
Topic Review
Solid-State Color Centers for Single-Photon Generation
Single-photon sources are important for integrated photonics and quantum technologies, and can be used in quantum key distribution, quantum computing, and sensing. Color centers in the solid state are a promising candidate for the development of the next generation of single-photon sources integrated in quantum photonics devices. They are point defects in a crystal lattice that absorb and emit light at given wavelengths and can emit single photons with high efficiency. 
  • 164
  • 20 Mar 2024
Topic Review
Postoperative Myocardial Infarction after Non-Cardiac Surgery
In patients undergoing major non-cardiac surgery, perioperative myocardial infarction (PMI) is a threatened complication. Every year, not less than 300 million non-cardiac surgery interventions are performed in the world. Perioperative mortality after non-cardiac surgery is estimated at 2% in patients over 45 years of age. Cardiovascular events account for half of these deaths, and most are due to perioperative myocardial infarction (MINS). The diagnosis of postoperative myocardial infarction, before the introduction of cardiac biomarkers, was based on symptoms and electrocardiographic changes and its incidence was largely underestimated. The incidence of MINS when a standard troponin assay is used ranges between 8 and 19% but increases to 20–30% with high-sensitivity troponin assays. Higher troponin values suggesting myocardial injury, both with or without a definite diagnosis of myocardial infarction, are associated with an increase in 30-day and 1-year mortality. 
  • 216
  • 20 Mar 2024
Topic Review
Improved Feature Selection for Social Internet of Things
The Social Internet of Things (SIoT) ecosystem tends to process and analyze extensive data generated by users from both social networks and Internet of Things (IoT) systems and derives knowledge and diagnoses from all connected objects. To overcome many challenges in the SIoT system, such as big data management, analysis, and reporting, robust algorithms should be proposed and validated. 
  • 83
  • 20 Mar 2024
Topic Review
Game Theory Models to Support Manufacturing Systems
Game theory is a branch of mathematics that studies strategic decision making in situations where multiple agents interact with each other. It provides a framework for analyzing and predicting the behavior of players in competitive and cooperative scenarios. Game theory is a powerful tool for analyzing strategic decision making in various contexts.
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  • 20 Mar 2024
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