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Topic Review
Tungurahua Volcano (Ecuador)
Since April of 2015, the ash dispersion and ash fallout due to Vulcanian eruptions at Tungurahua, one of the most active volcanoes in Ecuador, have been forecasted daily. For this purpose, our forecasting system uses the meteorological Weather Research and Forecasting (WRF) and the FALL3D models. Previously, and based on field data, laboratory, and numerical studies, corresponding eruption source parameters (ESP) have been defined. We analyzed the historically forecasted results of the ash fallout quantities over four years (April 2015 to March 2019), in order to obtain the average isomass and probability maps for three-month periods: February–March–April (FMA), May–June–July (MJJ), August–September–October (ASO), and November–December–January (NDJ). Our results indicate similar ash fallout shapes during MJJ and ASO, with a clear and defined tendency toward the west of the volcano; this tendency is less defined during NDJ and FMA. The proximal region west of the volcano (about 100 km to the west) has the highest probability (>70%) of being affected by ash fallout. The distant region to the west (more than 100 km west) presented low to medium probabilities (10%–70%) of ash fallout. The cities of Guaranda (W, 60% to 90%), Riobamba (SW, 70%), and Ambato (NW, 50% to 60%) have the highest probabilities of being affected by ash fallout. Among the large Ecuadorian cities, Guayaquil (SW, 10% to 30%) has low probability, and Quito (N, ≤5%) and Cuenca (SSE, <5%) have very low probabilities of being affected by ash fallout. High ash clouds can move in different directions, compared to wind transport near the surface. Therefore, it is possible to detect ash clouds by remote sensing which, in Ecuador, is limited to the layers over the meteorological clouds, which move in a different direction than low wind; the latter produces ash fallout over regions in different directions compared to the detected ash clouds. In addition to the isomass/probability maps and detected ash clouds, forecasting is permanently required in Ecuador.
  • 1.0K
  • 21 Aug 2020
Topic Review
Tungsten Resources in Mine Waste
Tungsten is recognized as a critical metal due to its unique properties, economic importance, and limited sources of supply. It has wide applications where hardness, high density, high wear, and high-temperature resistance are required, such as in mining, construction, energy generation, electronics, aerospace, and defense sectors. The two primary tungsten minerals, and the only minerals of economic importance, are wolframite and scheelite. Secondary tungsten minerals are rare and generated by hydrothermal or supergene alteration rather than by atmospheric weathering. There are no reported concerns for tungsten toxicity. However, tungsten tailings and other residues may represent severe risks to human health and the environment. Tungsten metal scrap is the only secondary source for this metal but reprocessing of tungsten tailings may also become important in the future.
  • 1.4K
  • 12 Jul 2021
Topic Review
Tungsten Inert Gas Welding Process of Dissimilar Metals
Special attention is required when joining two materials with distinct chemical, physical and thermal properties in order to make the joint bond robust and rigid. Welded samples employing ER-309L filler wires had a microstructure consisting of a delta ferrite network in an austenite matrix. The tensile strength experimental results revealed that welding current, followed by GFR, was a highly influential parameter on tensile strength. Weld metals had higher hardness and flexural strength than stainless steel and carbon steel base metals. 
  • 953
  • 15 Jul 2022
Topic Review
Tungsten in Soil
Tungsten (W) occurs naturally in soils and the Earth’s crust is the most important source of this element. Tungsten reserves have been estimated to be approximately 3.1 Mt in ore deposits, where the metal exists mainly as a component of several minerals, such as wolframite (Fe, MnWO4) and scheelite (CaWO4).
  • 913
  • 26 Jul 2021
Topic Review
Tumour-Associated Carbohydrates as Cancer Targets
Glycans are essential players involved in the interaction between cells and the microenvironment, making them ideal targets for the development of new therapies against infections and cancer. Since they modulate membrane receptor affinities, immune recognition, protein-protein interactions, and cell signaling, among others, glycans have been shown to play a relevant role in normal and malignant cell behaviour. Therefore, the alteration of the glycophenotype derived from malignant transformation is one of the adaptive mechanisms that provides tumour cells with growth advantages over normal cells, selected in order to circumvent the control mechanisms of the tissue microenvironment and ensure tumour survival.
  • 380
  • 11 Apr 2023
Topic Review
Tumour-Agnostic Therapy for Pancreatic Cancer
The prognosis of patients with solid tumours has remarkably improved with the development of molecular-targeted drugs and immune checkpoint inhibitors. However, the improvements in the prognosis of pancreatic cancer and biliary tract cancer is delayed compared to other carcinomas, and the 5-year survival rates of distal-stage disease are approximately 10 and 20%, respectively. However, a comprehensive analysis of tumour cells using The Cancer Genome Atlas (TCGA) project has led to the identification of various driver mutations. Evidently, few mutations exist across organs, and basket trials targeting driver mutations regardless of the primary organ are being actively conducted. Such basket trials not only focus on the gate keeper-type oncogene mu-tations, such as HER2 and BRAF, but also focus on the caretaker-type tumour suppressor genes, such as BRCA1/2, mismatch repair-related genes, which cause hereditary cancer syndrome.
  • 357
  • 26 Feb 2021
Topic Review
Tumour Proliferation and Imaging Biomarkers
Imaging biomarkers play a key role in the identification of biological particularities within tumours and therefore are an important component of treatment personalisation in radiotherapy. Imaging techniques such as PET, SPECT, MRI that employ tumour-specific biomarkers already play a critical role in patient stratification towards individualized treatment. 
  • 544
  • 11 Oct 2021
Topic Review
Tumour Microenvironment in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is one of the most common and lethal cancers worldwide. Currently, treatments available for advanced HCC provide dismal chances of survival, thus there is an urgent need to develop more effective therapeutic strategies. While much of the focus of recent decades has been on targeting malignant cells, promising results have emerged from targeting the tumour microenvironment (TME). The extracellular matrix (ECM) is the main non-cellular component of the TME and it profoundly changes during tumorigenesis to promote the growth and survival of malignant cells.
  • 541
  • 26 Nov 2021
Topic Review
Tumour Microenvironment and Metabolism
Many of the factors associated with tumour progression and immune resistance, such as yin yang (YY)1 and glycogen synthase kinase (GSK)3β, regulate acetyl-CoA and the melatonergic pathway, thereby having significant impacts on the dynamic interactions of the different types of cells present in the tumour microenvironment. The association of the aryl hydrocarbon receptor (AhR) with immune suppression in the tumour microenvironment may be mediated by the AhR-induced cytochrome P450 (CYP)1b1-driven ‘backward’ conversion of melatonin to its immediate precursor N-acetylserotonin (NAS). NAS within tumours and released from tumour microenvironment cells activates the brain-derived neurotrophic factor (BDNF) receptor, TrkB, thereby increasing the survival and proliferation of cancer stem-like cells. Acetyl-CoA is a crucial co-substrate for initiation of the melatonergic pathway, as well as co-ordinating the interactions of OXPHOS and glycolysis in all cells of the tumour microenvironment. This provides a model of the tumour microenvironment that emphasises the roles of acetyl-CoA and the melatonergic pathway in shaping the dynamic intercellular metabolic interactions of the various cells within the tumour microenvironment. The potentiation of YY1 and GSK3β by O-GlcNAcylation will drive changes in metabolism in tumours and tumour microenvironment cells in association with their regulation of the melatonergic pathway. 
  • 154
  • 29 Feb 2024
Topic Review
Tumour Microenvironment
The totality of normal cells, blood vessels and molecules embedding the tumor cells and sustaining their growth, characterized by a continuous bidirectional reshaping.
  • 989
  • 02 Feb 2021
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