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Topic Review
Two phytochrome A Types in Plants
The phytochrome (phy) system of plants with the main phyA and phyB controls their development beginning from seed germination to fruiting and senescence. The regulation reactions are categorized into three modes—the very low and low fluence responses (VLFR and LFR) and the high irradiance responses (HIR). The phyA is unique among the other phytochromes; it is major in etiolated seedlings and light-labile, and mediates all the three photoresponse modes. The phyB is light-stable, dominates in deetiolated plants, and performs the LFR. The phyA is itself heterogeneous which may explain its functional complexity. It comprises two native types, phyA′ and phyA″, the products of post-translational modification of the molecule at the N-terminus, possibly, via serine phosphorylation. This alters chromophore-apoprotein interactions resulting in the different photochemical, phenomenological, and functional properties of the two phyA pools. The phyA′ is major, water-soluble, and light-labile; the phyA″ is minor, amphiphilic, and relatively light-stable. The phyA′ mediates the VLFR whereas the water-soluble fraction of phyA″ is responsible for the HIR and LFR, the processes taking place in the nucleus. The membrane- (protein-) associated fraction of phyA” is likely to participate in the cytoplasmic photoregulation processes. The phyA pools' functions—their mode, intensity and sign—depend on plant's species, genotype and organ/tissue. The evidence of the existence of the two distinct phyA types in a plant, and their physicochemical properties and their role in the phyA functioning are discussed.
  • 705
  • 17 May 2023
Topic Review
Two Non-Tablet Oral Formulations of L-Thyroxine
Increased knowledge of the pharmacokinetic characteristics of orally administered levothyroxine (L-T4) has improved individualization of dosing regimens. However, up to 40–45% of patients, depending on the leading cause of hypothyroidism, are still over- or, more often, undertreated. Unintentional non-adherence to L-T4 replacement therapy includes all situations of unintended drug–drug and drug–food interactions as well as fasting conditions that are not necessarily respected by patients. The non-tablet L-T4 soft-gel capsules and solution have proven bioequivalence with the usual L-T4 tablet Princeps and generic formulations. Clinical studies have suggested higher performance of non-tablet formulations than tablet in those patients with suboptimal adherence. 
  • 440
  • 22 Jul 2022
Topic Review
Two Medicine Formation
The Two Medicine Formation is a geological formation, or rock body, in northwestern Montana and southern Alberta that was deposited between 83.5 ± 0.7 Ma and 70.6 ± 3.4 Ma (million years ago), during Campanian (Late Cretaceous) time. It crops out to the east of the Rocky Mountain Overthrust Belt, and the western portion (about 600 metres or 2,000 feet thick) of this formation is folded and faulted while the eastern part, which thins out into the Sweetgrass Arch, is mostly undeformed plains. Below the formation are the nearshore (beach and tidal zone) deposits of the Virgelle Sandstone, and above it is the marine Bearpaw Shale. Throughout the Campanian, the Two Medicine Formation was deposited between the western shoreline of the Late Cretaceous Interior Seaway and the eastward advancing margin of the Cordilleran Overthrust Belt. The Two Medicine Formation is mostly sandstone, deposited by rivers and deltas.
  • 932
  • 10 Oct 2022
Topic Review
Two Grain Refinement Modes for Treating Metallic Materials
Metallic materials have been widely used as orthopedic implants in clinics for their good mechanical, physical, and chemical properties, but their slow osseointegration rate is still one of the main issues causing implantation failure. Grain refinement has recently attracted wide attention for its effective improvement of cell–material interaction for biometals.
  • 329
  • 26 May 2022
Topic Review
Two Faces of Vitamin C: AA vs. DHA
Historically, vitamin C has been associated with many regulatory processes that involve specific signaling pathways. Among the most studied signaling pathways are those involved in the regulation of aging, differentiation, neurotransmission, proliferation, and cell death processes in cancer. This wide variety of regulatory effects is due to the fact that vitamin C has a dual mechanism of action. The reduced form of vitamin C (ascorbic acid, AA) is an essential micronutrient of small size; it is soluble in water and has two dissociable protons with pKa values of 4.2 and 11.8. At physiological pH, its reduced form predominates as the monovalent ascorbate anion (AA); when it loses the second proton, it is oxidized to dehydroascorbic acid (DHA).
  • 630
  • 14 Jun 2022
Topic Review
Two Dimensional Window Design
Windowing is a process where an index limited sequence has its maximum energy concentrated in a finite frequency interval. This can be extended to an N-dimension where the N-D window has the limited support and maximum concentration of energy in a separable or non-separable N-D passband. The design of an N-dimensional window particularly a 2-D window finds applications in various fields such as spectral estimation of multidimensional signals, design of circularly symmetric and quadrantally symmetric non-recursive 2D filters, design of optimal convolution functions, image enhancement so as to reduce the effects of data-dependent processing artifacts, optical apodization and antenna array design.
  • 472
  • 21 Nov 2022
Topic Review
Two CONSTANS-like 16 Genes
CONSTANS (CO) is an important regulator of photoperiodic flowering and functions at a key position in the flowering regulatory network. Here, two CO homologs, MiCOL16A and MiCOL16B, were isolated from “SiJiMi” mango to elucidate the mechanisms controlling mango flowering. The MiCOL16A and MiCOL16B genes were highly expressed in the leaves and expressed at low levels in the buds and flowers. The expression levels of MiCOL16A and MiCOL16B increased during the flowering induction period but decreased during the flower organ development and flowering periods.
  • 432
  • 16 Mar 2022
Topic Review
Two Complementarity Immunotherapeutics in NSCLC
The idea of using two different immunotherapies in cancer patients is based on the attempt to stimulate or inhibit different immune cells at different levels of their activity (e.g., in the lymph node and in the tumour). The most commonly used combination immunotherapy involves antibodies that target molecules capable of stimulation of the activity of lymphocytes and other immune cells and molecules that are able to inhibit this activity. Another combination immunotherapy method is the use of immune checkpoint inhibitors in combination with agents that modify the tumour microenvironment in a non-specific manner (e.g., pro-inflammatory cytokines, immunosuppressive cytokine inhibitors, and indoleamine 2,3-dioxygenase and adenosine inhibitors).
  • 366
  • 24 Jun 2021
Topic Review
Two BAHD Acetyltransferases in Jasminum sambac (L.) Aiton
Volatile benzenoid compounds are found in diverse aromatic bouquets emitted by most moth-pollinated flowers. The night-blooming Jasminum sambac is widely cultivated worldwide in the tropics and subtropics for ornamental and industrial purposes owing to its fragrant flowers. 
  • 403
  • 17 Jan 2022
Topic Review
Two Analytical Approaches of Quantitative Imaging
As the most lethal major cancer, pancreatic cancer is a global healthcare challenge. Personalized medicine utilizing cutting-edge multi-omics data holds potential for major breakthroughs in tackling this critical problem. Radiomics and deep learning, two trendy quantitative imaging methods that take advantage of data science and modern medical imaging, have shown increasing promise in advancing the precision management of pancreatic cancer via diagnosing of precursor diseases, early detection, accurate diagnosis, and treatment personalization and optimization. Radiomics employs manually-crafted features, while deep learning applies computer-generated automatic features. These two methods aim to mine hidden information in medical images that is missed by conventional radiology and gain insights by systematically comparing the quantitative image information across different patients in order to characterize unique imaging phenotypes. Both methods have been studied and applied in various pancreatic cancer clinical applications. 
  • 423
  • 13 Apr 2022
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