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Topic Review
Two-Ray Ground-Reflection Model
The Two-Rays Ground Reflected Model is a radio propagation model which predicts the path losses between a transmitting antenna and a receiving antenna when they are in LOS (line of sight). Generally, the two antenna each have different height. The received signal having two components, the LOS component and the multipath component formed predominantly by a single ground reflected wave.
  • 7.3K
  • 08 Nov 2022
Topic Review
Two-Pore Domain TASK Potassium Channels
TWIK-related acid-sensitive K+ (TASK) channels, including TASK-1, TASK-3, and TASK-5, are important members of the two-pore domain potassium (K2P) channel family. TASK-5 is not functionally expressed in the recombinant system. TASK channels are very sensitive to changes in extracellular pH and are active during all membrane potential periods. They are similar to other K2P channels in that they can create and use background-leaked potassium currents to stabilize resting membrane conductance and repolarize the action potential of excitable cells. TASK channels are expressed in both the nervous system and peripheral tissues, including excitable and non-excitable cells, and are widely engaged in pathophysiological phenomena, such as respiratory stimulation, pulmonary hypertension, arrhythmia, aldosterone secretion, cancers, anesthesia, neurological disorders, glucose homeostasis, and visual sensitivity. Therefore, they are important targets for innovative drug development. 
  • 466
  • 19 Dec 2022
Topic Review
Two-Pore Channels and Ca2+ Homeostasis in Immune Cells
Two-pore channels (TPCs) are ligand-gated cation-selective ion channels that are preserved in plant and animal cells. In the latter, TPCs are located in membranes of acidic organelles, such as endosomes, lysosomes, and endolysosomes. Mast cells, along with basophil granulocytes, play an essential role in anaphylaxis and allergic reactions by releasing inflammatory mediators. Signaling in mast cells is mainly regulated via the release of Ca2+ from the endoplasmic reticulum as well as from acidic compartments, such as endolysosomes. For the crosstalk of these organelles TPCs seem essential. Allergic reactions and anaphylaxis were previously shown to be associated with the endolysosomal two-pore channel TPC1. The release of histamine, controlled by intracellular Ca2+ signals, was increased upon genetic or pharmacologic TPC1 inhibition. Conversely, stimulation of TPC channel activity by one of its endogenous ligands, namely nicotinic adenine dinucleotide phosphate (NAADP) or phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2), were found to trigger the release of Ca2+ from the endolysosomes; thereby improving the effect of TPC1 on regulated mast cell degranulation. 
  • 407
  • 16 May 2022
Topic Review
Two-Photon Imaging
Two-photon imaging (2PI) is a fluorescence-based laser scanning microscopy technique commonly used in studies across various fields of research, including neurobiology, embryology, and tissue engineering. In principle, it involves two infrared photons simultaneously exciting a single fluorophore in a sample, thereby causing it to emit light in a specific wavelength region, also called fluorescence emission spectrum. This fluorescence is normally detected in a wavelength region close to the maximum of this spectrum, allowing the sample to be identified based on its specific fluorescent characteristics.
  • 663
  • 15 Apr 2021
Topic Review
Two-Photon Absorbing Dendrimers
Dendrimers, arborescent macromolecules exhibiting a large number of functional groups at their surface, appeared as naturally attractive targets to consider as TPA chromophores. Indeed, dendrimers are a special kind of perfectly defined hyperbranched polymers constructed stepwise from a multifunctional core at the periphery of which can be grafted a large density and variety of chromophores.
  • 331
  • 14 Mar 2024
Topic Review
Two-Phase Immersion Cooling with Surface Modifications
As an alternative method to the practical limitations of air cooling, liquid cooling methods have drawn attention. Liquid cooling can dissipate heat up to 202 W/cm2, which is approximately six times higher than that of conventional air cooling. The liquid cooling can be divided into one-phase driven by a pump and two-phase cooling using pool boiling.
  • 1.2K
  • 11 Mar 2022
Topic Review
Two-Phase Fermentation Systems for Microbial Production of Terpenes
Microbial cell factories, renowned for their economic and environmental benefits, have emerged as a key trend in academic and industrial areas, particularly in the fermentation of natural compounds. Among these, plant-derived terpenes stand out as a significant class of bioactive natural products. The large-scale production of such terpenes, exemplified by artemisinic acid—a crucial precursor to artemisinin—is now feasible through microbial cell factories. In the fermentation of terpenes, two-phase fermentation technology has been widely applied due to its unique advantages. It facilitates in situ product extraction or adsorption, effectively mitigating the detrimental impact of product accumulation on microbial cells, thereby significantly bolstering the efficiency of microbial production of plant-derived terpenes. 
  • 273
  • 02 Apr 2024
Topic Review
Two-Nation Theory (Pakistan)
The two-nation theory (Urdu: دو قومی نظریہ‎ do qaumī nazariya) is the basis of the creation of Pakistan . According to this theory Muslims and Hindus are two separate nations by definition; Muslims have their own customs, religion, and tradition, and from social and moral points of view, Muslims are different from Hindus; and therefore, Muslims should be able to have their own separate homeland in which Islam is the dominant religion, being segregated from Hindus. The two-nation theory advocated by the All India Muslim League is the founding principle of the Pakistan Movement (i.e. the ideology of Pakistan as a Muslim nation-state in the northwestern and eastern regions of India) through the partition of India in 1947. There are varying interpretations of the two-nation theory, based on whether the two postulated nationalities can coexist in one territory or not, with radically different implications. One interpretation argued for sovereign autonomy, including the right to secede, for Muslim-majority areas of colonial India, but without any transfer of populations (i.e. Hindus and Muslims would continue to live together). A different interpretation contends that Hindus and Muslims constitute "two distinct and frequently antagonistic ways of life and that therefore they cannot coexist in one nation." In this version, a transfer of populations (i.e. the total removal of Hindus from Muslim-majority areas and the total removal of Muslims from Hindu-majority areas) is a desirable step towards a complete separation of two incompatible nations that "cannot coexist in a harmonious relationship". Opposition to the two-nation theory came from both nationalist Muslims and Hindus, being based on two concepts. The first is the concept of a single Indian nation, of which Hindus and Muslims are two intertwined communities. The second source of opposition is the concept that while Indians are not one nation, neither are the Muslims or Hindus of India, and it is instead the relatively homogeneous provincial units of the Indian subcontinent which are true nations and deserving of sovereignty; this view has been presented by the Baloch, Sindhi, Bengali, and Pashtun sub-nationalities of Pakistan, with Bengalis seceding from Pakistan after the Bangladesh Liberation War in 1971 and other separatist movements in Pakistan are currently in-place. The state of India officially rejected the two-nation theory and chose to be a secular state, enshrining the concepts of religious pluralism and composite nationalism in its constitution; however, in response to the separatist tendencies of the All India Muslim League, many Hindu nationalist organisations worked to try to give Hinduism a privileged position within the country.
  • 90.3K
  • 02 Dec 2022
Topic Review
Two-Line Hybrid Rice Breeding
This entry enlightens a deep understanding of the molecular control of MF in EGMS liens and exploring the regulatory driving forces that function efficiently during plant adaptation under a changing environment. 
  • 1.7K
  • 11 Nov 2020
Topic Review Peer Reviewed
Two-Lane Highways: Indispensable Rural Mobility
Two-lane highways refer to roadways consisting of two lanes in the cross section, one for each direction of travel. Occasionally, passing lanes may be added to one or two sides of the roadway extending the cross section to three or four lanes at those locations. In this entry, two-lane highways strictly refer to roads in rural areas meeting the previous definition and do not include urban and suburban streets.
  • 3.1K
  • 13 Apr 2022
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