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Topic Review
Ureteroenteric Strictures
Benign ureteroenteric anastomosis strictures (UESs) are one of many critical complications that may cause irreversible disability following robot-assisted radical cystectomy (RARC).
  • 423
  • 29 Oct 2021
Topic Review
Ureteral Neuroendocrine Neoplasms
Primary ureteral neuroendocrine neoplasms (NENs) are rare. Small-cell neuroendocrine cancer (NEC) of the ureter is usually observed in elderly patients, and around 15 cases have been observed in females so far.
  • 394
  • 14 Jul 2022
Topic Review
Uremic Toxins Control in CKD
Uremic toxins (UTs) are mainly produced by protein metabolized by the intestinal microbiota and converted in the liver or by mitochondria or other enzymes. The accumulation of UTs can damage the intestinal barrier integrity and cause vascular damage and progressive kidney damage. Together, these factors lead to metabolic imbalances, which in turn increase oxidative stress and inflammation and then produce uremia that affects many organs and causes diseases including renal fibrosis, vascular disease, and renal osteodystrophy. This article is based on the theory of the intestinal–renal axis, from bench to bedside, and it discusses nonextracorporeal therapies for UTs, which are classified into three categories: medication, diet and supplement therapy, and complementary and alternative medicine (CAM) and other therapies. The effects of medications such as AST-120 and meclofenamate are described. Diet and supplement therapies include plant-based diet, very low-protein diet, probiotics, prebiotics, synbiotics, and nutraceuticals. The research status of Chinese herbal medicine is discussed for CAM and other therapies. This review can provide some treatment recommendations for the reduction of UTs in patients with chronic kidney disease.
  • 1.3K
  • 10 Sep 2021
Topic Review
Uremic Toxins Affect the Endothelium
Uremic toxins can induce endothelial dysfunction in patients with chronic kidney disease (CKD). Indeed, the structure of the endothelial monolayer is damaged in CKD, and studies have shown that the uremic toxins contribute to the loss of cell–cell junctions, increasing permeability. Membrane proteins, such as transporters and receptors, can mediate the interaction between uremic toxins and endothelial cells. In these cells, uremic toxins induce oxidative stress and activation of signaling pathways, including the aryl hydrocarbon receptor (AhR), nuclear factor kappa B (NF-κB), and mitogen-activated protein kinase (MAPK) pathways. The activation of these pathways leads to overexpression of proinflammatory (e.g., monocyte chemoattractant protein-1, E-selectin) and prothrombotic (e.g., tissue factor) proteins. Uremic toxins also induce the formation of endothelial microparticles (EMPs), which can lead to the activation and dysfunction of other cells, and modulate the expression of microRNAs that have an important role in the regulation of cellular processes.
  • 717
  • 26 Oct 2021
Topic Review
Uremic Toxins
Some uremic toxins such as indol acetic acid, indoxyl sulfate, p-cresyl sulfate hippuric acid, phenyl sulfate, trimethylamine N-oxide, and hydrogen sulfide in the blood of CKD patients come from the metabolism of bacteria in the gut. As a result of the conducted research, the list of potential uremic toxins is constantly being modified. For example, it is suggested that the current list of cytokines that are considered potential uremic toxins is incomplete and excessive.
  • 1.3K
  • 28 Jun 2021
Topic Review
Uremic Sarcopenia
Uremic sarcopenia is a frequent condition present in chronic kidney disease (CKD) patients and is characterized by reduced muscle mass, muscle strength and physical performance. Uremic sarcopenia is related to an increased risk of hospitalization and all-causes mortality. This pathological condition is caused not only by advanced age but also by others factors typical of CKD patients such as metabolic acidosis, hemodialysis therapy, low-grade inflammatory status and inadequate protein-energy intake. Currently, treatments available to ameliorate uremic sarcopenia include nutritional therapy (oral nutritional supplement, inter/intradialytic parenteral nutrition, enteral nutrition, high protein and fiber diet and percutaneous endoscopic gastrectomy) and a personalized program of physical activity. 
  • 707
  • 24 Apr 2021
Topic Review
Urease Inhibitory Activity
In our work, both Et-OH and Me-OH extracts of H. rhamnoides (91.69%±1.21) and C. fistula (79.44%±0.55) showed stronger action against urease activity. An overview on the medicinal uses of H. rhamnoides and C. fistula showing anti-urease activity may predict their possible alternative use for stomach problems. 
  • 594
  • 28 Dec 2020
Topic Review
Urbanization alters soil microbial communities
Urban development is one of the leading causes of biodiversity change. Understanding how soil microorganisms respond to urbanization is particularly important because they are crucial for the provisioning of ecosystem functions and services. Our results showed that microbial richness and community composition exhibited nonsignificant changes over time regardless of the location. Soil fungal richness was lower in moderately and highly urbanized locations, but soil bacterial/archaeal richness was not significantly different among locations. Both bacteria/archaea and fungi exhibited significant differences in community composition across locations. After inferring potential functional groups, soils in the highly urbanized location had lower proportions of arbuscular mycorrhizal fungi and soil saprotrophic fungi but had higher proportions of bacterial taxa involved in aromatic compound degradation, human pathogens, and intracellular parasites. Furthermore, ammonia-oxidizing bacteria were more abundant in the highly urbanized location, but ammonia-oxidizing archaea were more abundant in lowly and moderately urbanized locations. Together, these results highlight the significant changes in belowground microbial communities across an urbanization gradient, and these changes might have important implications for aboveground–belowground interactions, nutrient cycling, and human health.
  • 1.0K
  • 21 Jul 2021
Topic Review
Urbanization
Urbanization (or urbanisation) refers to the population shift from rural to urban areas, the decrease in the proportion of people living in rural areas, and the ways in which societies adapt to this change. It is predominantly the process by which towns and cities are formed and become larger as more people begin living and working in central areas. Although the two concepts are sometimes used interchangeably, urbanization should be distinguished from urban growth. Whereas urbanization refers to the proportion of the total national population living in areas classified as urban, urban growth strictly refers to the absolute number of people living in those areas. The United Nations has projected that half of the world's population will live in urban areas at the end of 2008. It is predicted that by 2050 about 64% of the developing world and 86% of the developed world will be urbanized. That is equivalent to approximately 3 billion urbanites by 2050, much of which will occur in Africa and Asia. Notably, the United Nations has also recently projected that nearly all global population growth from 2017 to 2030 will be by cities, with about 1.1 billion new urbanites over the next 10 years. Urbanization is relevant to a range of disciplines, including urban planning, geography, sociology, architecture, economics, and public health. The phenomenon has been closely linked to modernization, industrialization, and the sociological process of rationalization. Urbanization can be seen as a specific condition at a set time (e.g. the proportion of total population or area in cities or towns), or as an increase in that condition over time. Therefore, urbanization can be quantified either in terms of the level of urban development relative to the overall population, or as the rate at which the urban proportion of the population is increasing. Urbanization creates enormous social, economic and environmental changes, which provide an opportunity for sustainability with the "potential to use resources more efficiently, to create more sustainable land use and to protect the biodiversity of natural ecosystems." Urbanization is not merely a modern phenomenon, but a rapid and historic transformation of human social roots on a global scale, whereby predominantly rural culture is being rapidly replaced by predominantly urban culture. The first major change in settlement patterns was the accumulation of hunter-gatherers into villages many thousand years ago. Village culture is characterized by common bloodlines, intimate relationships, and communal behavior, whereas urban culture is characterized by distant bloodlines, unfamiliar relations, and competitive behavior. This unprecedented movement of people is forecast to continue and intensify during the next few decades, mushrooming cities to sizes unthinkable only a century ago. As a result, the world urban population growth curve has up till recently followed a quadratic-hyperbolic pattern. Today, in Asia the urban agglomerations of Osaka, Tokyo, Mumbai, Dhaka, Karachi, Jakarta, Shanghai, Chongqing, Guangzhou, Manila, Seoul, and Beijing are each already home to over 20 million people, while Delhi is forecast to approach or exceed 40 million people in the year 2035. Cities such as Tehran, Istanbul, Mexico City, São Paulo, London, Moscow, New York City, Lagos, Los Angeles, and Cairo are, or soon will be, home to over 15 million people each.
  • 4.9K
  • 09 Oct 2022
Topic Review
Urbanisation on Green Growth within Sustainable Development Goals
Urbanisation enhances dissemination of the green knowledge and innovative technologies, bridging gaps in living conditions and making services (health, digital, etc.) available and affordable.
  • 419
  • 21 Mar 2024
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