Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort:
Hottest Latest Alphabetical (A-Z) Alphabetical (Z-A)
Type:
All Topic Review Biography
Topic Review
Vinaya
The Vinaya (Pali & Sanskrit) is the division of the Buddhist canon (Tripitaka) containing the rules and procedures that govern the Buddhist monastic community, or sangha. Three parallel Vinaya traditions remain in use by modern monastic communities: the Theravada (Sri Lanka & Southeast Asia), Mulasarvastivada (Tibetan Buddhism and the Himalayan region) and Dharmaguptaka (East Asian Buddhism). In addition to these Vinaya traditions, Vinaya texts of several extinct schools of Indian Buddhism are preserved in the Tibetan and East Asian canons, including those of the Kāśyapīya, the Mahāsāṃghika, the Mahīśāsaka, and the Sarvāstivāda The word Vinaya is derived from a Sanskrit verb that can mean to lead, take away, train, tame, or guide, or alternately to educate or teach. It is often translated as 'discipline', with Dhamma-vinaya, 'doctrine and discipline', used by the Buddha to refer to his complete teachings, suggesting its integral role in Buddhist practice.
  • 1.9K
  • 08 Oct 2022
Topic Review
Vimentin-Binding Aptamer Motifs for Ovarian Cancer
The application of aptamers in biomedicine is emerging as an essential technology in the field of cancer research. As small single-stranded DNA or RNA ligands with high specificity and low immunogenicity for their targets, aptamers provide many advantages in cancer therapeutics over protein-based molecules, such as antibodies. Vimentin is an intermediate filament protein that is overexpressed in endothelial cells of cancerous tissue. High expression levels of vimentin have been associated with increased capacity for migration and invasion of the tumor cells. We have selected and identified thioated aptamers with high specificity for vimentin using human ovarian cancer tissues. Tentative binding motifs were chosen for two vimentin aptamers based on predicted secondary structures. Each of these shorter, tentative binding motifs was synthesized, purified, and characterized via cell binding assays. Two vimentin binding motifs with high fidelity binding were selected and further characterized via cell and tissue binding assays, as well as flow cytometric analysis. The equilibrium binding constants of these small thioated aptamer constructs were also determined. Future applications for the vimentin binding aptamer motifs include conjugation of the aptamers to synthetic dyes for use in targeted imaging and therapy, and ultimately more detailed and precise monitoring of treatment response and tumor progression in ovarian pathology. 
  • 621
  • 11 Nov 2021
Topic Review
Vimentin in Oral Cancers
Oral carcinogenesis is a multistep process. As much as 5% to 85% of oral tumors can develop from potentially malignant disorders (PMD). Although the oral cavity is accessible for visual examination, the ability of current clinical or histological methods to predict the lesions that can progress to malignancy is limited.
  • 511
  • 08 Feb 2022
Topic Review
Vimentin at the Heart of Epithelial Mesenchymal Transition
Epithelial-mesenchymal transition (EMT) is a reversible plethora of molecular events where epithelial cells gain the phenotype of mesenchymal cells to invade the surrounding tissues. EMT is a physiological event during embryogenesis (type I) but also happens during fibrosis (type II) and cancer metastasis (type III). It is a multifaceted phenomenon governed by the activation of genes associated with cell migration, extracellular matrix degradation, DNA repair, and angiogenesis. The cancer cells employ EMT to acquire the ability to migrate, resist therapeutic agents and escape immunity. One of the key biomarkers of EMT is vimentin, a type III intermediate filament that is normally expressed in mesenchymal cells but is upregulated during cancer metastasis. 
  • 808
  • 22 Oct 2021
Topic Review
VIMANA
The "Vimana" is one such concept in ancient Indian texts that has been in the spotlight of most scholars, historians, and enthusiasts of ancient technology. Indeed, Vimanas, as they are described in Hindu epics or Vedic literature, flying machines or celestial chariots have amazed many a knowledgeable intellect, and some even go to the extent of citing them as evidence for advanced knowledge in aeronautical science in ancient India.
  • 492
  • 21 Jun 2024
Topic Review
Village Business Sustainability in Indonesia
Village-owned enterprises are expected to be a forum for village business groups to develop their economic potential. The village-owned enterprises runs a business that resembles the business fields of the villagers. This situation has unconsciously created a sense of competition for both parties. The atmosphere of competition between the two business entities has the potential to hinder the growth of the village’s local economy. Village-owned enterprises evaluate their business activities and build a cooperation network for the sustainability of rural businesses.
  • 183
  • 28 Sep 2023
Topic Review
Villa Tunari Massacre
The Villa Tunari Massacre was a 27 June 1988 mass murder committed by UMOPAR (Rural Patrol Mobile Unit) troops in response to a protest by coca-growing peasants (cocaleros) in the town of Villa Tunari in Chapare Province, Bolivia. The cocalero movement had mobilized since late May 1988 in opposition to coca eradication under Law 1008, then on the verge of becoming law. According to video evidence and a joint church-labor investigative commission, UMOPAR opened fired on unarmed protesters, at least two of whom were fatally shot, and many of whom fled to their deaths over a steep drop into the San Mateo River. The police violence caused the deaths of 9 to 12 civilian protesters, including three whose bodies were never found, and injured over a hundred. The killings were followed by further state violence in Villa Tunari, Sinahota, Ivirgarzama, and elsewhere in the region, including machine gun fire, beatings, and arrests. The massacre helped bring about the consolidation of Chapare coca growers' unions into the Coordinadora of the Six Federations of the Tropic of Cochabamba. Representatives of the National Congress, Catholic Church, Permanent Assembly for Human Rights, and the Central Obrera Boliviana labor federation formed a joint "multisectoral commission" to investigate the repression in the Chapare, which traveled to the region on 30 June 1988.
  • 533
  • 04 Nov 2022
Topic Review
Vilevolodon
Vilevolodon is an extinct, monotypic genus of volant, arboreal euharamiyids from the Oxfordian age of the Late Jurassic of China. The type species is Vilevolodon diplomylos. The genus name Vilevolodon references its gliding capabilities, Vilevol (Latin for “glider”), while don (Greek for “tooth”) is a common suffix for mammalian taxon titles. The species name diplomylos refers to the dual mortar-and-pestle occlusion of upper and lower molars observed in the holotype; diplo (Greek for “double”), mylos (Greek for “grinding”). Vilevolodon is known from the Tiaojishan Formation in Qinglong County, China. Due to its unique combination of characters, Vilevolodon provides additional evidence to an increasingly complex scope of mammalian morphology and niche inhabitation. As the volant herbivorous lifestyle is previously only known from therian gliders, Vilevolodon stands as evidence of locomotor convergence, as well as mammaliaform evolutionary experimentation during the Jurassic. Along with Maiopatagium, Vilevolodon represents the most primitive known gliders in mammalian evolution, appearing approximately 100 million years before the earliest known therian gliders.
  • 576
  • 01 Dec 2022
Biography
Vilém Flusser
Vilém Flusser (May 12, 1920 – November 27, 1991) was a Czech-born philosopher, writer and journalist. He lived for a long period in São Paulo (where he became a Brazilian citizen) and later in France, and his works are written in many different languages. His early work was marked by discussion of the thought of Martin Heidegger, and by the influence of existentialism and phenomenology. Ph
  • 945
  • 15 Dec 2022
Topic Review
Vilabouly Complex, Laos
The Vilabouly Complex is an archaeological site that is located in the Savannakhet Province in Laos which holds copper smelting and copper mining during the Iron Age. The Vilabouly Complex is significant since it puts archaeologists in a predicament of when did the origin of bronze metallurgy begin in Southeast Asia. It was estimated that the site was around 400BC - AD 500 as well as 1000 - 400BC reaching both the Iron Age and Bronze Age of Southeast Asia. The site contained a lead signature that followed copper, bronze alloys, and bronze which signifies a massive source of material that can benefit metallurgy in the region. By this, the Vilabouly Complex will hold all the power of the region since it has all the resources to advance their technology during the Bronze and Iron Ages. The Vilabouly Complex and the region contained such mining sites such as Dragon Field, Peun Balo, Tengkham South D, Khanong A2, and the Malachite Cave. These sites all refer to the Iron Age but Peun Balo revealed mining in the Bronze Age continuing the predicament for Archaeologists. Research like this is vital for the Vilabouly Complex to find and understand the exact date to when the people of Southeast Asia are trading metals, and sharing mining techniques. There are also other sites in region such as the Prachan Valley that shared a lot of similarities to that of the Vilabouly Complex revealing continuities for the Southeast Asian people.
  • 289
  • 01 Nov 2022
  • Page
  • of
  • 5495
Featured Entry Collections
>>

Featured Books

>>
Encyclopedia of Social Sciences
Encyclopedia of COVID-19
Encyclopedia of Fungi
Encyclopedia of Digital Society, Industry 5.0 and Smart City
ScholarVision Creations
Feedback