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Topic Review
Biography
Topic Review
Campylobacter Upsaliensis
Campylobacter upsaliensis is a gram negative bacteria in the Campylobacter genus. C. upsaliensis is found worldwide, and is a common cause of Campylobacteriosis in humans, as well as gastroenteritis in dogs. Human infections are primarily associated with raw or undercooked meat and contaminated water sources, however there is some zoonotic risk associated with the spread from dogs. C. upsaliensis primarily affects the gastrointestinal tract as it damages gastrointestinal epithelial cells. There are many methods for detecting C.upsaliensis including PCR and ELISA, however there is no current gold standard in detection techniques. Infection is typically self limiting, however there is antimicrobial therapy available.
1.2K
30 Sep 2022
Topic Review
Candida auris
Candida auris is considered to be an emerging fungal pathogen and is related to high mortality rates, persistent candidemia, inconsistencies in susceptibility testing results and misidentification by available commercial identification systems. Multidrug-resistant (MDR) and pandrug-resistant (PDR) strains are increasingly detected. In Europe, hospital outbreaks caused by C. auris have been reported in the United Kingdom (UK), Italy and Spain.
406
15 Feb 2023
Topic Review
Candida
in Oral Malignancy
Candida albicans is a commensal fungal species that commonly colonizes the human body, but it is also a pervasive opportunistic pathogen in patients with malignant diseases. A growing body of evidence suggests that this fungus is not only coincidental in oncology patients, but may also play an active role in the development of cancer. More specifically, several studies have investigated the potential association between C. albicans and various types of cancer, including oral, esophageal, and colorectal cancer, with a possible role of this species in skin cancer as well. The proposed mechanisms include the production of carcinogenic metabolites, modulation of the immune response, changes in cell morphology, microbiome alterations, biofilm production, the activation of oncogenic signaling pathways, and the induction of chronic inflammation. These mechanisms may act together or independently to promote cancer development.
303
10 Oct 2023
Topic Review
Candidiasis
Candida spp. can be found colonizing the skin, oral mucosa, and/or the gastrointestinal and genitourinary tracts in healthy individuals. Most cases of subsequent disease usually emerge from this endogenous microbiota. Although there are now more than 200 species of Candida identified, only a relatively small and yet not clearly defined number (~10–20) have been reported in the context of disease in children and adults. Historically, C. albicans has been, by far, the most commonly isolated species, although the rates of non-albicans species have variably increased globally, probably due to modifications in prophylactic approaches as well as changes in the characteristics of the most vulnerable patient populations, such as preterm neonates and immunosuppressed children. Overall, Candida infections in children can be divided into two main disease presentations: chronic mucocutaneous candidiasis, which can manifest as oropharyngeal candidiasis (OPC, also known as “thrush”), esophagitis, diaper dermatitis, onychomycosis, and/or vulvovaginitis, and invasive candidiasis (IC).
525
02 Feb 2023
Topic Review
Cannabis sativa
Bioactive Compounds in Colorectal Cancer
Cannabis sativa is a multipurpose plant that has been used in medicine for centuries. Considerable research has focused on the bioactive compounds of this plant, particularly cannabinoids and terpenes. Among other properties, these compounds exhibit antitumor effects in several cancer types, including colorectal cancer (CRC). Cannabinoids show positive effects in the treatment of CRC by inducing apoptosis, proliferation, metastasis, inflammation, angiogenesis, oxidative stress, and autophagy. Terpenes, such as β-caryophyllene, limonene, and myrcene, have also been reported to have potential antitumor effects on CRC through the induction of apoptosis, the inhibition of cell proliferation, and angiogenesis. In addition, synergy effects between cannabinoids and terpenes are believed to be important factors in the treatment of CRC.
468
18 May 2023
Topic Review
Carcino
-
Evo
-
Devo
The term “carcino-evo-devo” was used for the first time as a name for the theory of the evolutionary role of tumors. The new term was coined from two other terms: “carcinoembryonic” and “evo-devo”.
341
18 May 2023
Topic Review
Carica papaya
Leaf Juice for Dengue
Dengue, an Aedes mosquito-borne viral infection, has become a public health risk that demands the world’s focus, especially in tropical countries. Despite of the life-threatening complication, there are still no specific antiviral medications for dengue infection. This situation highlight the research need in identifying potent compounds with promising anti-dengue activities. Therefore, a scoping review was conducted to gather and highlight the available scientific evidence for the use of C. papaya leaf, particularly using juice form, as a complementary method in treating dengue infection.
874
21 Apr 2022
Topic Review
Cassia alata
(Linnaeus) Roxburgh for Skin
Atopic dermatitis (AD) is an inflamed skin condition with relapsing pruritus and cutaneous physiological dysfunction. This skin disorder is widespread around the world and frequently affects infants, children and adults. Natural products with bioactive lead compounds are the source of natural medicines for complementary and alternative therapy in managing AD. Cassia alata (Senna alata) has been used traditionally as a remedy for a variety of health issues. Cassia alata is also known as ringworm cassia. This plant is perennial and is known as a ‘candle bush’ due to its shape and inflorescences.
671
08 Feb 2023
Topic Review
Castanea mollissima
Chestnut (Castanea spp., Fagaceae family) is an economically important tree in the wood processing industry that occurs in Asia, Europe, Africa, and the Americas. There are four most important and cultivated chestnut varieties: C. molissima (Chinese chestnut) and C. crenata (Japanese chestnut) are distributed in Asia; C. sativa is distributed in continental Europe (European chestnut); and Castanea dentata is distributed in North America (American chestnut). Chestnuts are a source of nuts and industrial raw materials, including wood, that can be used as firewood, as well as to build timber and barrels for winemaking. Extracts from chestnut shells (e.g., tannins, polyphenols, and polysaccharides), female flower, and spring buds have been applied in the medical, pharmaceutical, and healthcare fields. Discarded chestnut shells, inner shells, burs, and leaves have been re-utilized as biomass and catalyst material. The important economic and environmental roles of chestnut underlie its high value to ecosystems and agroforestry systems.
610
16 Sep 2022
Topic Review
Castanea sativa Mill.
Chemical Composition
The European chestnut (Castanea sativa Mill.), is an environmentally and economically important species in Europe, mainly for fruit production. The chestnut fruit is well-known for its nutritional properties, namely its high concentration of carbohydrates (starch) and its low-fat content, as well as being one of the few fruits that do not contain gluten. Due to its chemical and nutritional characteristics beneficial to health, the sweet chestnut is a food recommended at different levels.
660
12 Jan 2023
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