Topic Review
Mendelian Susceptibility to Mycobacterial Disease
The diagnosis and treatment of patients with mendelian susceptibility to mycobacterial disease (MSMD) pose consistent challenges due to the diverse infection spectrum observed in this population. Common clinical manifestations include Bacillus Calmette-Guérin vaccine (BCG) complications in countries where routine BCG vaccination is practiced, while in non-BCG-vaccinating countries, Non-Tuberculous Mycobacteria (NTM) is prevalent. In tuberculosis-endemic regions, Mycobacterium tuberculosis (MTB) has a high prevalence, along with other intracellular organisms.
  • 297
  • 06 Mar 2024
Topic Review
Neuromuscular Blocking Agents
The use of neuromuscular blocking agents (NMBAs) is common in the intensive care unit (ICU). NMBAs have been used in critically ill patients with lung diseases to optimize mechanical ventilation, prevent spontaneous respiratory efforts, reduce the work of breathing and oxygen consumption, and avoid patient–ventilator asynchrony.
  • 285
  • 06 Mar 2024
Topic Review
Exercise Stress Echocardiography in Athletes
Exercise stress echocardiography (ESE) is a crucial diagnostic tool, offering detailed insights into an athlete’s cardiac function, reserve, and possible arrhythmias.
  • 87
  • 06 Mar 2024
Topic Review
Pharmacology of Cynomorium songaricum
Cynomorium songaricum Rupr. (CSR) belongs to the family Cynomoriaceae. It is a perennial succulent parasitic herb with a reddish-brown coloration, predominantly submerged in sand and lacking chlorophyll. 
  • 201
  • 06 Mar 2024
Topic Review
Gut Microbiota, Inflammation, and Obesity
The increased prevalence of obesity and several other metabolic disorders, including diabetes and non-alcoholic fatty liver disease, has reached global pandemic proportions. Lifestyle changes may result in a persistent positive energy balance, hastening the onset of these age-related disorders and consequently leading to a diminished lifespan. Although suggestions have been raised on the possible link between obesity and the gut microbiota, progress has been hampered due to the extensive diversity and complexities of the gut microbiota. Being recognized as a potential biomarker owing to its pivotal role in metabolic activities, the dysregulation of the gut microbiota can give rise to a persistent low-grade inflammatory state associated with chronic diseases during aging.
  • 112
  • 06 Mar 2024
Topic Review
N-Glycans’ Effect on Pathologic Protein Conformations in Disease
Glycosylation, a prevalent post-translational modification, plays a pivotal role in regulating intricate cellular processes by covalently attaching glycans to macromolecules. Dysregulated glycosylation is linked to a spectrum of diseases, encompassing cancer, neurodegenerative disorders, congenital disorders, infections, and inflammation. Considering the allosteric effects of N-glycans in regulating protein conformation, with potential implications for its assembly and function, it is of no surprise that dysregulated N-glycosylation has been implicated in several disease-associated human proteins. Furthermore, these glycans may play a pivotal role in modulating the conformation of pathogen-associated proteins, influencing their infectivity within human cells.
  • 248
  • 06 Mar 2024
Topic Review
Aptamer Technologies in Neuroscience
Aptamers developed using in vitro Systematic Evolution of Ligands by Exponential Enrichment (SELEX) technology are single-stranded nucleic acids 10–100 nucleotides in length. Their targets, often with specificity and high affinity, range from ions and small molecules to proteins and other biological molecules as well as larger systems, including cells, tissues, and animals. Aptamers often rival conventional antibodies with improved performance, due to aptamers’ unique biophysical and biochemical properties, including small size, synthetic accessibility, facile modification, low production cost, and low immunogenicity. Therefore, there is sustained interest in engineering and adapting aptamers for many applications, including diagnostics and therapeutics. 
  • 180
  • 06 Mar 2024
Topic Review
Biomedical Applications of Bimetallic Coordination Polymers
Bimetallic coordination polymers (CPs) have two different metal ions as connecting nodes in their polymer structure. The synthesis methods of bimetallic CPs are mainly categorized into the one-pot method and post-synthesis modifications according to various needs. Compared with monometallic CPs, bimetallic CPs have synergistic effects and excellent properties, such as higher gas adsorption rate, more efficient catalytic properties, stronger luminescent properties, and more stable loading platforms, which have been widely applied in the fields of gas adsorption, catalysis, energy storage as well as conversion, and biosensing.
  • 145
  • 06 Mar 2024
Topic Review
Energy Storage in Urban Areas
Positive Energy Districts can be defined as connected urban areas, or energy-efficient and flexible buildings, which emit zero greenhouse gases and manage surpluses of renewable energy production. Energy storage is crucial for providing flexibility and supporting renewable energy integration into the energy system. It can balance centralized and distributed energy generation, while contributing to energy security. Energy storage can respond to supplement demand, provide flexible generation, and complement grid development. Photovoltaics and wind turbines together with solar thermal systems and biomass are widely used to generate electricity and heating, respectively, coupled with energy system storage facilities for electricity (i.e., batteries) or heat storage using latent or sensible heat. Energy storage technologies are crucial in modern grids and able to avoid peak charges by ensuring the reliability and efficiency of energy supply, while supporting a growing transition to nondepletable power sources.
  • 259
  • 06 Mar 2024
Topic Review
Application of Aquaporins as Markers in Forensic Pathology
Aquaporins (AQPs) in various forensic fields has offered a promising horizon in response to the need to have reliable elements for the identification of the manner of death and for the individuation of forensic markers for the timing of lesions and vitality of injury.
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  • 06 Mar 2024
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