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Topic Review
Light-Driven Semiconductor-Based Micro/Nanomotors
Micro/nanomotors represent a burgeoning field of research featuring small devices capable of autonomous movement in liquid environments through catalytic reactions and/or external stimuli.
  • 232
  • 18 Mar 2024
Topic Review
Mechanisms behind the Guar Drought Tolerance
Guar is an unpretentious plant and grows on both sandy and well-drained clay soils. Guar is self-pollinating with a negligible level of cross-pollination. The plants considerably vary in height (from 50 cm to 1.5 m). The stem is sturdy, becoming woody by the plant maturation. The main root is thick and tapering in its distal parts, deeply penetrating into the soil. Due to this, guar can perfectly sustain short-term drought. 
  • 228
  • 15 Mar 2024
Topic Review
Technological Advancements for Neuromodulation and Biofeedback
Primary objectives of neurofeedback training (NFT) are to improve concentration, stress and anxiety management, and performance optimisation. NFT, a form of biofeedback that uses real-time displays of electroencephalography (EEG) to teach the self-regulation of brain functions, has emerged as a promising approach for improving the mental skills that are essential for high-level performance in precision sports. 
  • 137
  • 15 Mar 2024
Topic Review
Common Pathways of Apoptotic Cell Death
The common signaling pathways of apoptotic cell death, antiapoptotic pathways, non-apoptotic cell death mechanisms (autophagic, necrotic, and other), signaling pathways involved in the death of drug-sensitive and -resistant tumor cells (with emphasis on c-Jun/activator protein 1 and crosstalk with mitochondrial and endoplasmic reticulum pathways), and therapeutic implications of the modification of signaling pathways leading to cell death (with emphasis on cell death-related gene targeting, interactions of drug resistance factors in drug-resistant cells, and the unfolded protein response pathway). 
  • 120
  • 15 Mar 2024
Topic Review
Unfolded Protein Response in Ischemic Stroke
Many pathologic states can lead to the accumulation of unfolded/misfolded proteins in cells. This causes endoplasmic reticulum (ER) stress and triggers the unfolded protein response (UPR), which encompasses three main adaptive branches. One of these UPR branches is mediated by protein kinase RNA-like ER kinase (PERK), an ER stress sensor. The primary consequence of PERK activation is the suppression of global protein synthesis, which reduces ER workload and facilitates the recovery of ER function. Ischemic stroke induces ER stress and activates the UPR. 
  • 103
  • 15 Mar 2024
Topic Review
Immunomodulatory Function of Vitamin D
Hashimoto’s thyroiditis (HT), also known as chronic autoimmune thyroiditis, is the most prevalent organ-specific autoimmune disorder. Hashimoto’s thyroiditis (HT) is marked by self-tissue destruction as a consequence of an alteration in the adaptive immune response that entails the evasion of immune regulation. Vitamin D carries out an immunomodulatory role that appears to promote immune tolerance.
  • 137
  • 15 Mar 2024
Topic Review
MicroRNAs in Depression
Depression is a major contributor to the overall global burden of disease. The discovery of biomarkers for diagnosis or prediction of treatment responses and as therapeutic agents is a current priority. Previous studies have demonstrated the importance of short RNA molecules in the etiology of depression. The most extensively researched of these are microRNAs, a major component of cellular gene regulation and function. MicroRNAs function in a temporal and tissue-specific manner to regulate and modify the post-transcriptional expression of target mRNAs. They can also be shuttled as cargo of extracellular vesicles between the brain and the blood, thus informing about relevant mechanisms in the CNS through the periphery. 
  • 84
  • 15 Mar 2024
Topic Review
Biomedical Applications of Poly(Propylene Carbonate)
Poly(propylene carbonate) (PPC) is an emerging “carbon fixation” polymer that holds the potential to become a “biomaterial of choice” in healthcare owing to its good biocompatibility, tunable biodegradability and safe degradation products. Several physical, chemical and biological modifications of PPC have been achieved by introducing biocompatible polymers, inorganic ions or small molecules, which can endow PPC with better cytocompatibility and desirable biodegradability, and thus enable various applications. Indeed, a variety of PPC-based degradable materials have been used in medical applications including medical masks, surgical gowns, drug carriers, wound dressings, implants and scaffolds. 
  • 267
  • 15 Mar 2024
Topic Review
Protein-Bound Uremic Toxin in Chronic Kidney Disease
Uremic toxins (UTs), particularly protein-bound uremic toxins (PBUTs), accumulate in chronic kidney disease (CKD) patients, causing significant health complications like uremic syndrome, cardiovascular disease, and immune dysfunction. Innovations such as online hemodiafiltration aim to enhance the removal process, while novel adsorptive therapies offer a means to address the high affinity of PBUTs to plasma proteins. 
  • 89
  • 15 Mar 2024
Topic Review
Microscopy Diagnosis of Trichomoniasis
More than one million curable sexually transmitted infections occur every day. Trichomonas vaginalis is one of the main infections responsible for these epidemiological data. The diagnosis of this protozoan is mainly based on microscopic and culture identification. 
  • 97
  • 15 Mar 2024
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