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Topic Review
CDKN2A/B Homozygous Deletions in Astrocytomas
The CDKN2A and CDKN2B genes are located on the short arm of chromosome 9. CDKN2A encodes for two proteins, p14 and p16, and CDKN2B encodes for p15. These proteins regulate cell growth and angiogenesis. Interpreting the impact of CDKN2A/B alterations on astrocytoma prognosis is complicated by the changes in tumour classification and a lack of uniform standards for testing CDKN2A/B. While the prognostic impact of CDKN2A/B HD is established, the role of different CDKN2A/B alterations—heterozygous deletions (HeD), point mutations, and promoter methylation—is less clear. Consequently, how these alternations should be incorporated into patient management remains controversial.
  • 738
  • 05 Jul 2023
Topic Review
Chenopodium album
Bathua (Chenopodium album) is a rich source of extensive-ranging nutrients, including bio-active carbohydrates, flavonoids and phenolics, minerals, and vitamins that translate to countless health benefits such as anticancer, antidiabetic, anti-inflammatory, antimicrobial, and antioxidant activity. Ascaridole, an important phytoconstituent present in aerial parts of the plant, contributes to its anthelmintic property. 
  • 931
  • 05 Jul 2023
Topic Review
Chlorophytum tuberosum
Chlorophytum tuberosum (C. tuberosum) belongs to the family Liliaceae and is being used in the indigenous systems of medicine as a galactagogue, aphrodisiac, antitumor, immunomodulatory, antidiabetic, analgesic, anti-inflammatory, hypolipidemic, anti-ageing, antimicrobial, etc. 
  • 682
  • 11 Apr 2023
Topic Review
Cistus albidus L.
Cistus albidus is one of the approximately 20 species of the Cistus genus. The genus’ name is derived from the ancient Greek term kistos. It is supposed that the name alludes to the woody capsule fruits. Evergreen in its Mediterranean homeland and between 50 and 250 centimeters tall, this shrub is called albidus, not because of the colour of its flowers, but because its leaves are finely covered with white hair (trichomes).
  • 148
  • 23 May 2024
Topic Review
Cistus ladanifer as a Potential Feedstock for Biorefineries
Cistus ladanifer (rockrose) is a widespread shrub species in the Mediterranean region well known due to its production of labdanum gum, especially in the hot season. Its leaves and branches can be subjected to different extraction and distillation processes to produce various types of extracts. The natural extracts of C. ladanifer have several applications, especially in the perfumery and cosmetics sector. C. ladanifer extracts, in addition to presenting interesting odoriferous properties, are also known for their bioactive properties, such as antioxidant and antimicrobial. The use of this species in animal feed or phytostabilisation of mining areas has also been successfully applied. Furthermore, the lignin and polysaccharides that are the major fractions from Cistus residues can be relevant sources of high-value products in a biorefinery framework.
  • 832
  • 02 Feb 2023
Topic Review
Citrobacter sp. in Fish
Fish is considered a highly nutritious food that constitutes the human diet, produced through fishing and aquaculture activities, to be marketed and consumed around the world in different presentations and culinary preparations. Fish is also very susceptible to spoilage and contamination by microorganisms throughout the food chain, which may be part of the usual microbiota or incorporated into food derived from inadequate hygiene practices in the food industry. Fish has been associated worldwide with disease outbreaks derived from consumption, where various bacteria and/or metabolites (biogenic amines) are some of the main casual agents. Citrobacter sp. is considered a pathogen in fish, as well as in humans, derived from the consumption of contaminated food, generating infections or histamine poisoning as it is part of the generating microbiota.
  • 521
  • 19 Jun 2023
Topic Review
Citrus Uses in the Food Industry
Citrus fruits occupy an important position in the context of the fruit trade, considering that both fresh fruits and processed products are produced on a large scale. Citrus fruits are recognized as an essential component of the human diet, thanks to their high content of beneficial nutrients such as vitamins, minerals, terpenes, flavonoids, coumarins and dietary fibers. Among these, a wide range of positive biological activities are attributed to terpenes and flavonoids derivatives.
  • 2.0K
  • 03 Mar 2023
Topic Review
Citrus hystrix DC for Metabolic Disorders
Metabolic disorder, which includes hypertension, diabetes mellitus, dyslipidemia, and obesity, represents a major global health concern due to increased morbidity and mortality. It occurs due to disturbance in normal metabolic process leading to redox and energy imbalance. Metabolic disorder, which includes hypertension, diabetes mellitus, dyslipidemia, and obesity, represents a major global health concern due to increased morbidity and mortality. It occurs due to disturbance in normal metabolic process leading to redox and energy imbalance.
  • 647
  • 10 Feb 2023
Topic Review
Cladosporium Entomopathogenicity
The range of interactions between Cladosporium, a ubiquitous fungal genus, and insects, a class including about 60% of the animal species, is extremely diverse. Conventionally, Cladosporium species are not considered full-right representatives of the guild of entomopathogens, which is generally restricted to specialized fungi such as Beauveria, Metarhizium and Lecanicillium/Akanthomyces. However, like other fungi that are widely associated with crops such as Trichoderma and Talaromyces, the evidence is increasing that Cladosporium may also infect insects and cause epizootics in pest populations or promote plant defense reactions.
  • 111
  • 02 Feb 2024
Topic Review
Clostridioides difficile Infection in Inflammatory Bowel Diseases Patients
Clostridioides difficile (C. difficile) represents a major health burden with substantial economic and clinical impact. Patients with inflammatory bowel diseases (IBD) were identified as a risk category for Clostridioides difficile infection (CDI). In addition to traditional risk factors for C. difficile acquisition, IBD-specific risk factors such as immunosuppression, severity and extension of the inflammatory disease were identified. C. difficile virulence factors, represented by both toxins A and B, induce the damage of the intestinal mucosa and vascular changes, and promote the inflammatory host response. Given the potential life-threatening complications, early diagnostic and therapeutic interventions are required. The screening for CDI is recommended in IBD exacerbations, and the diagnostic algorithm consists of clinical evaluation, enzyme immunoassays (EIAs) or nucleic acid amplification tests (NAATs). An increased length of hospitalization, increased colectomy rate and mortality are the consequences of concurrent CDI in IBD patients. Selection of CD strains of higher virulence, antibiotic resistance, and the increasing rate of recurrent infections make the management of CDI in IBD more challenging.
  • 618
  • 08 Aug 2022
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