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Topic Review
Beeswax
Beeswax is one of the natural waxes that have been used as a support ingredient in cosmetic and pharmaceutical formulations. Although it has well-known healing properties, it remains a secondary and poorly valued product, particularly in South American countries' apiarian production. In Latin America, for example, the apiarian activity can be traced back to stingless bees in pre-Columbian times. Then, with the arrival of the Spaniards in the 16th century, honey bees (Apis mellifera iberian and A. m. mellifera) were introduced, which were joined afterward by other breeds such as A. m. ligustica and A. m. scutellata. Over the years, honey has been the main product from the apiarian farmers, being beeswax a secondary product, mainly used for the regular renewal procedure of the hives. Nowadays, beeswax's cosmetic and pharmaceutical use is found at the level of small laboratories and small businesses.
  • 5.1K
  • 10 Oct 2022
Topic Review
Cultural Heritage and Tourism
The integration of the cultural/creative and tourism industries is one way to present different types of regional cultural heritage to the world. With the growth of scenic towns and the revitalization of rural areas due to mass tourism, intangible cultural heritage has become an important tourism and cultural resource. The numbers of domestic and foreign tourists visiting these traditional cultural resources are on the rise every year. Many areas with rich cultural resources rely on tourism to alleviate poverty and achieve revitalization. However, a region’s tourism resources are not always proportional to its cultural heritage. It is important to carefully study the methods of regional tourism resource development, while also fully integrating cultural resources.
  • 5.1K
  • 30 Jun 2022
Topic Review
Levetiracetam Mechanisms of Action
Epilepsy is a chronic disease that affects millions of people worldwide. Antiepileptic drugs (AEDs) are used to control seizures. Even though parts of their mechanisms of action are known, there are still components that need to be studied. Therefore, the search for novel drugs, new molecular targets, and a better understanding of the mechanisms of action of existing drugs is still crucial. Levetiracetam (LEV) is an AED that has been shown to be effective in seizure control and is well-tolerable, with a novel mechanism of action through an interaction with the synaptic vesicle protein 2A (SV2A). Moreover, LEV has other molecular targets that involve calcium homeostasis, the GABAergic system, and AMPA receptors among others, that might be integrated into a single mechanism of action that could explain the antiepileptogenic, anti-inflammatory, neuroprotective, and antioxidant properties of LEV. This puts it as a possible multitarget drug with clinical applications other than for epilepsy.
  • 5.1K
  • 27 Apr 2022
Topic Review
AI Control Problem
In artificial intelligence (AI) and philosophy, the AI control problem is the issue of how to build AI systems such that they will aid their creators, and avoid inadvertently building systems that will harm their creators. One particular concern is that humanity will have to solve the control problem before a superintelligent AI system is created, as a poorly designed superintelligence might rationally decide to seize control over its environment and refuse to permit its creators to modify it after launch. In addition, some scholars argue that solutions to the control problem, alongside other advances in AI safety engineering, might also find applications in existing non-superintelligent AI. Major approaches to the control problem include alignment, which aims to align AI goal systems with human values, and capability control, which aims to reduce an AI system's capacity to harm humans or gain control. Capability control proposals are generally not considered reliable or sufficient to solve the control problem, but rather as potentially valuable supplements to alignment efforts.
  • 5.1K
  • 22 Nov 2022
Topic Review
Support Needs in Intellectual Disability
“Support needs” is a psychological construct referring to the pattern and intensity of supports necessary for a person to participate in activities linked with normative human functioning.
  • 5.1K
  • 11 Jan 2021
Topic Review
Lithium-Ion Battery Fire Suppression
Lithium-ion Batteries (LiBs) hazards, techniques for mitigating risks, the suppression of LiB fires and identification of shortcomings for future improvement were thoroughly reviewed. Water is identified as an efficient cooling and suppressing agent and water mist is considered the most promising technique to extinguish LiBs fire. 
  • 5.1K
  • 29 Apr 2021
Topic Review
Ti Nitrides and Ti Silicides
The diffusion of nitrogen into TiSi2 films of low electrical resistivity, deposited on complementary metal oxyde semiconductor (CMOS) and Schottky diodes components increases their performances. TiN acts as a good diffusion barrier, gate material, Schottky barrier contact...Both TiSi2 and TiN are synthesized in Ti films coated on Si wafers and processed in an expanding microwave plasma producing nitrogen species such as NHx...This process promotes the chemical reactions at the surface of the metal. The growth of both compounds give rise to two competing processes which are thermodynamically and kinetically controlled. Ti films, 250 nm thick, processed at 600°C for  30 min, only consist of TiSi2 crystallites and TiN of amorphous structure. TiN crystallizes at 800°C and grows at the expense of TiSi2 according to thermodynamic data. 
  • 5.1K
  • 30 Oct 2020
Topic Review
Emulsion Gel and Its Preparation
Emulsion gels are emulsion with a gel network structure and stable mechanical properties. Emulsion gel formation is considered a strategy for oil stabilization and structuring, presenting advantages such as transporting functional components and improving the sensory and physical product properties. 
  • 5.1K
  • 15 Jul 2022
Topic Review
Deep Cryogenic Treatment
Deep cryogenic treatment (DCT) is a type of cryogenic treatment, where a metallic material is subjected to temperatures below -150°C, normally to temperatures of liquid nitrogen (-196 °C). When a material is exposed to DCT as a part of heat treatment, changes in microstructure are induced due to new grain formation, changes in grain size, change in the solubility of atoms, movement of dislocations, alteration of crystal structure, and finally new phase formation. The metallic material's performance and later performance of manufactured components and tools from this specific material are dependent on the selection of proper design, proper material, accuracy with which the tool is made and application of proper heat treatment, including any eventual DCT. Metallic materials are ferrous and non-ferrous metals. In the last years ferrous metals (different grades of steel) and non-ferrous alloys (aluminum, magnesium, titanium, nickel etc.) have been increasingly treated with DCT to alter their properties. DCT treatment has shown to reduce density of defects in crystal structure, increase wear resistance of material, increase hardness, improve toughness, and reduce tensile strength and corrosion resistance. However, some researchers also reported results showing no change in properties (toughness, hardness, corrosion resistance, etc.) or even deterioration when subjected to DCT treatment. This leads to a lack of consistency and reliability of the treatment process, which is needed for successful application in industry. This review provides a synopsis of DCT usage and resulting effects on treated materials used in automotive industry.
  • 5.1K
  • 29 Oct 2020
Topic Review
Pathogenic Bacteria
Pathogenic bacteria are bacteria that can cause disease. This article focuses on the bacteria that are pathogenic to humans. Most species of bacteria are harmless and are often beneficial but others can cause infectious diseases. The number of these pathogenic species in humans is estimated to be fewer than a hundred. By contrast, several thousand species are part of the gut flora present in the digestive tract. The body is continually exposed to many species of bacteria, including beneficial commensals, which grow on the skin and mucous membranes, and saprophytes, which grow mainly in the soil and in decaying matter. The blood and tissue fluids contain nutrients sufficient to sustain the growth of many bacteria. The body has defence mechanisms that enable it to resist microbial invasion of its tissues and give it a natural immunity or innate resistance against many microorganisms. Pathogenic bacteria are specially adapted and endowed with mechanisms for overcoming the normal body defences, and can invade parts of the body, such as the blood, where bacteria are not normally found. Some pathogens invade only the surface epithelium, skin or mucous membrane, but many travel more deeply, spreading through the tissues and disseminating by the lymphatic and blood streams. In some rare cases a pathogenic microbe can infect an entirely healthy person, but infection usually occurs only if the body's defence mechanisms are damaged by some local trauma or an underlying debilitating disease, such as wounding, intoxication, chilling, fatigue, and malnutrition. In many cases, it is important to differentiate infection and colonization, which is when the bacteria are causing little or no harm. Caused by Mycobacterium tuberculosis bacteria, one of the diseases with the highest disease burden is tuberculosis, which killed 1.4 million people in 2019, mostly in sub-Saharan Africa. Pathogenic bacteria contribute to other globally important diseases, such as pneumonia, which can be caused by bacteria such as Streptococcus, Pneumococcus and Pseudomonas, and foodborne illnesses, which can be caused by bacteria such as Shigella, Campylobacter, and Salmonella. Pathogenic bacteria also cause infections such as tetanus, typhoid fever, diphtheria, syphilis, and leprosy. Pathogenic bacteria are also the cause of high infant mortality rates in developing countries. Most pathogenic bacteria can be grown in cultures and identified by Gram stain and other methods. Bacteria grown in this way are often tested to find which antibiotics will be an effective treatment for the infection. For hitherto unknown pathogens, Koch's postulates are the standard to establish a causative relationship between a microbe and a disease.
  • 5.1K
  • 07 Nov 2022
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