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Topic Review
Insulin Signaling
The insulin signaling pathway begins with the binding of the peptide hormone insulin to its corresponding receptor, the insulin receptor. The insulin receptor is a receptor tyrosine kinase (RTK) that conformationally consists of two alpha and two beta subunit tetramers. The insulin receptor exhibiting kinase activity is responsible for its autophosphorylation at the tyrosine residue site upon insulin binding.
  • 6.3K
  • 28 Sep 2021
Topic Review
Nature Sports
Nature sports comprise a group of sporting activities that are developed and experienced in natural or rural areas, ranging from formal to informal practices. These practices are performed in a variety of natural contexts including on land (mountain biking, rock-climbing, trekking, etc.), in water (kayaking, sailing, surfing, windsurfing, etc.), and in the air (paragliding and hang-gliding, etc.). Nature sports have a spontaneous, playful nature, "with participation predominantly taking place in informal settings, often without governing bodies or clubs or other forms of external regulation". They are generally autonomous activities, even if some nature sports are practiced collectively, such as kayaking, or those which create sporting sub-cultures, such as in surfing.
  • 6.3K
  • 06 Sep 2021
Topic Review
Anodizing
Anodizing is an electrochemical process by which the thickness of the natural oxide layer present on metals is increased. Anodizing is used to improve the corrosion and wear resistance of the substrate, to enhance the adhesion of coatings and for aesthetics reasons. The properties, chemistry and morphology of the resulting anodic oxide film depend on the anodizing parameters chosen.
  • 6.3K
  • 25 Jan 2021
Topic Review
Shenyang J-31
The Shenyang J-31 (or "FC-31 fifth Generation Multi-Purpose light Fighter") also known as the "Gyrfalcon" (鹘鹰), or "Falcon Hawk" by some military enthusiasts, is a twin-engine, mid-size fifth-generation jet fighter currently under development by Shenyang Aircraft Corporation. The fighter has also been referred to as the "F-60" or "J-21 Snowy Owl" (雪鸮) in some media reports. Its official name is Shenyang FC-31; J-xx nomenclatures in the Chinese military are reserved to programs launched and financed by the army, while this plane was developed by a state-owned company.
  • 6.3K
  • 10 Nov 2022
Topic Review
Paper
Paper is a thin material produced by pressing together moist fibres of cellulose pulp derived from wood, rags or grasses, and drying them into flexible sheets. It is a versatile material with many uses, including writing, printing, packaging, cleaning, decorating, and a number of industrial and construction processes. Papers are essential in legal or non-legal documentation. The pulp papermaking process is said to have been developed in China during the early 2nd century CE, possibly as early as the year 105 CE, by the Han court eunuch Cai Lun, although the earliest archaeological fragments of paper derive from the 2nd century BCE in China. The modern pulp and paper industry is global, with China leading its production and the United States right behind it.
  • 6.3K
  • 30 Oct 2022
Topic Review
Take This Lollipop
Take This Lollipop is a 2011 interactive horror short film and Facebook app written and directed by Jason Zada. It uses the Facebook Connect application to bring viewers themselves into the film, through use of pictures and messages from their own Facebook profiles. Starring actor Bill Oberst Jr. as 'The Facebook Stalker', the film acts to personalize and underscore the dangers inherent in posting too much personal information about oneself on the internet. The information gathered from a viewer's Facebook profile by the film's app is used once, and then deleted. The title is derived from the 1963 song "Please Little Girl Take This Lollipop", written and performed by singer-songwriter Bobby Jameson, which is used in the film. According to Zada, Take This Lollipop was taken offline "a few months" prior to August 2018. The film's website now hosts a Facebook post by him, saying that the data needed had become "quite hard to access" and had affected the functionality of the film.
  • 6.3K
  • 20 Oct 2022
Topic Review
Anti-COVID-19 potential of Clove phytochemicals
The current COronaVIrus Disease 19 (COVID-19) pandemic caused by SARS-CoV-2 infection is enormously affecting the worldwide health and economy. In the wait for an effective global immunization, the development of a specific therapeutic protocol to treat COVID-19 patients is clearly necessary as a short-term solution of the problem. Drug repurposing and herbal medicine represent two of the most explored strategies for an anti-COVID-19 drug discovery. Clove (Syzygium aromaticum L.) is a well-known culinary spice that has been used for centuries in folk medicine in many disorders. Interestingly, traditional medicines have used clove since ancient times to treat respiratory ailments, whilst clove ingredients show antiviral and anti-inflammatory properties. Other interesting features are the clove antithrombotic, immunostimulatory, and antibacterial effects.
  • 6.2K
  • 13 May 2021
Topic Review
Separatist Feminism
Separatist feminism is a form of radical feminism that holds that opposition to patriarchy is best done through focusing exclusively on women and girls. Some separatist feminists believe that men cannot make positive contributions to the feminist movement and that even well-intentioned men replicate the dynamics of patriarchy. Author Marilyn Frye describes separatist feminism as "separation of various sorts or modes from men and from institutions, relationships, roles and activities that are male-defined, male-dominated, and operating for the benefit of males and the maintenance of male privilege – this separation being initiated or maintained, at will, by women". In a tract on socialist feminism published in 1972, the Hyde Park Chapter of the Chicago Women's Liberation Union differentiated between separatism as an "ideological position" and as a "tactical position". In the same document, they further distinguished between separatism as "personal practice" and as "political position".
  • 6.2K
  • 27 Oct 2022
Topic Review
Parental Involvement
Parental involvement is seen as an important strategy for the advancement of the quality of education. The ultimate objective of this is to expand the academic and social capacities of students, especially those of disadvantaged backgrounds determined by ethnic minority origin and low socio-economic status. In this contribution, various forms of both parental and school-initiated involvement will be described. In addition, results of studies into the effectiveness of parental involvement will be presented.
  • 6.2K
  • 15 Nov 2021
Topic Review
Evolution of Elephants
Elephants are the largest existing land animals. Three living species are currently recognised: the African bush elephant, the African forest elephant, and the Asian elephant. They are an informal grouping within the proboscidean family Elephantidae. Elephantidae is the only surviving family of proboscideans; extinct members include the mastodons. Elephantidae also contains several extinct groups, including the mammoths and straight-tusked elephants. African elephants have larger ears and concave backs, whereas Asian elephants have smaller ears, and convex or level backs. The distinctive features of all elephants include a long proboscis called a trunk, tusks, large ear flaps, massive legs, and tough but sensitive skin. The trunk is used for breathing, bringing food and water to the mouth, and grasping objects. Tusks, which are derived from the incisor teeth, serve both as weapons and as tools for moving objects and digging. The large ear flaps assist in maintaining a constant body temperature as well as in communication. The pillar-like legs carry their great weight. Elephants are scattered throughout sub-Saharan Africa, South Asia, and Southeast Asia and are found in different habitats, including savannahs, forests, deserts, and marshes. They are herbivorous, and they stay near water when it is accessible. They are considered to be keystone species, due to their impact on their environments. Elephants have a fission–fusion society, in which multiple family groups come together to socialise. Females (cows) tend to live in family groups, which can consist of one female with her calves or several related females with offspring. The groups, which do not include bulls, are usually led by the oldest cow, known as the matriarch. Males (bulls) leave their family groups when they reach puberty and may live alone or with other males. Adult bulls mostly interact with family groups when looking for a mate. They enter a state of increased testosterone and aggression known as musth, which helps them gain dominance over other males as well as reproductive success. Calves are the centre of attention in their family groups and rely on their mothers for as long as three years. Elephants can live up to 70 years in the wild. They communicate by touch, sight, smell, and sound; elephants use infrasound, and seismic communication over long distances. Elephant intelligence has been compared with that of primates and cetaceans. They appear to have self-awareness, and appear to show empathy for dying and dead family members. African bush elephants and Asian elephants are listed as endangered and African forest elephants as critically endangered by the International Union for Conservation of Nature (IUCN). One of the biggest threats to elephant populations is the ivory trade, as the animals are poached for their ivory tusks. Other threats to wild elephants include habitat destruction and conflicts with local people. Elephants are used as working animals in Asia. In the past, they were used in war; today, they are often controversially put on display in zoos, or exploited for entertainment in circuses. Elephants are highly recognisable and have been featured in art, folklore, religion, literature, and popular culture.
  • 6.2K
  • 28 Nov 2022
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