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Topic Review
In-Line Inspection (ILI) Techniques for Subsea Pipelines
Offshore oil and gas resources play a crucial role in supplementing the energy needs of human society. The crisscrossing subsea pipeline network, which serves as vital infrastructure for the storage and transportation of offshore oil and gas, requires regular inspection and maintenance to ensure safe operation and prevent ecological pollution. In-line inspection (ILI) techniques have been widely used in the detection and inspection of potential hazards within the pipeline network. 
  • 125
  • 12 Mar 2024
Topic Review
Mitochondria and Carcinogenesis
Mitochondria are commonly perceived as “cellular power plants”. In addition to energy conversion, mitochondria play many other roles in cell operations. They act in calcium signaling, stress response, and stem cell regulation and also serve as general cellular signaling hubs. They regulate aging and control cell death (apoptosis). Mitochondria play a crucial role as a mediator between the extracellular matrix (ECM) and the cell nucleus, and monitoring and controlling this relationship can be important for cancer prevention and treatment. Mitochondrial defects can include aberrated metabolism (the Warburg effect) or signaling dysfunction (reactive oxygen species or reactive oxygen species (ROS) production).
  • 115
  • 12 Mar 2024
Topic Review
Mechanisms of Cognitive Impairment in Chronic Kidney Disease
A notable feature of dementia in chronic kidney disease (CKD) patients is the high frequency of vascular dementia, making its prevention through the management of classical risk factors such as hypertension, diabetes mellitus, dyslipidemia, smoking, etc., associated with atherosclerosis and arteriosclerosis. Other effective measures, including the use of renin–angiotensin system inhibitors, addressing anemia, exercise therapy, and lifestyle improvements, have been reported. The incidence and progression of cognitive impairment (CI) may also be influenced by the type of kidney replacement therapy, with reports suggesting that long-duration dialysis, low-temperature hemodialysis, peritoneal dialysis, and kidney transplantation can have a preferable effect on the preservation of cognitive function. In conclusion, patients with CKD are at a higher risk of developing CI, with brain atrophy being a contributing factor. 
  • 117
  • 12 Mar 2024
Topic Review
The Concept of Child-Centred Care in Healthcare
The position of children in healthcare reflects their changing and evolving positioning in society more broadly. The concept of child-centred care orientates children to a more central position within children’s healthcare, where the child is at the centre of thinking and practice. However, a clear definition of child-centred care and clarity around the concept is yet to be achieved.
  • 279
  • 12 Mar 2024
Topic Review
Carbon Emission Characteristics of Railways
Rail transportation plays a crucial role in reducing carbon emissions from the transportation system, making a significant contribution to environmental impact mitigation due to the efficiency of passenger and freight rail transportation. Estimates of greenhouse gas (GHG) emissions impacts into the atmosphere are intrinsically linked to the modernization of transportation system, due this sector still heavily relies on fossil fuels, such as gasoline and diesel. In the context of studying GHG emissions and their life cycle, it is common to assess different alternatives to identify the most sustainable options. For example, when comparing different transportation systems, one can analyze not only the direct emissions from vehicles but also emissions associated with the manufacturing, maintenance, and operation of infrastructure such as roads, rails, or airports 
  • 125
  • 12 Mar 2024
Topic Review
Selected Conventional and Alternative Sweeteners on Gastrointestinal Hormones
Sugar consumption is known to be associated with a whole range of adverse health effects, including overweight status and type II diabetes mellitus. Alternative sweeteners have gained interest as substitutes for conventional sweeteners, such as sucrose, glucose, or fructose, to achieve a reduction in sugar intake without loss of the sweet taste. Several human studies have shed light on the differential effects of conventional sweeteners (glucose, fructose, and sucrose) and alternative sweeteners on metabolic parameters such as gastrointestinal (GI) hormone secretion, gastric emptying rates, energy intake, glycemic control, blood lipids, and uric acid. 
  • 88
  • 12 Mar 2024
Topic Review
Failures of the Photovoltaic Module Components
With the global increase in the deployment of photovoltaic (PV) modules, the need to explore and understand their reported failure mechanisms has become crucial. Despite PV modules being considered reliable devices, failures and extreme degradations often occur. Some degradations and failures within the normal range may be minor and not cause significant harm. Others may initially be mild but can rapidly deteriorate, leading to catastrophic accidents, particularly in harsh environments.
  • 165
  • 12 Mar 2024
Topic Review
Zinc Transporters in Different Biological Kingdoms
Zinc transporters take up/release zinc ions (Zn2+) across biological membranes and maintain intracellular and intra-organellar Zn2+ homeostasis. Since this process requires a series of conformational changes in the transporters, detailed information about the structures of different reaction intermediates is required for a comprehensive understanding of their Zn2+ transport mechanisms. Various Zn2+ transport systems have been identified in bacteria, yeasts, plants, and humans. 
  • 163
  • 12 Mar 2024
Topic Review
Post-Discectomy Infection
Postoperative discitis (POD) accounts for 20% to 30% of all cases of pyogenic spondylodiscitis, while POD may be mis-or-under-diagnosed, due to the vague related symptomatology and the non-specific imaging findings. Most studies report infection rate of less than 1%, which increases with the addition of non-instrumented fusion to 2.4% to 6.2%. The onset of POD symptoms usually occurs at 2–4 weeks after an apparently uneventful operation. Back pain and muscle spasms are usually refractory to bed rest and analgesics. Magnetic Resonance Imaging (MRI) is the most sensitive and specific imaging diagnostic technique. Antimicrobial therapy depends on the results of tissue cultures, and along with bracing represents the mainstay of management. Surgical intervention is necessary in patients failing conservative treatment. For the majority of cases, extensive surgical debridement, antibiotic therapy, and orthosis immobilization are effective in eliminating the infection.
  • 95
  • 12 Mar 2024
Topic Review
Satellite Constellations in Internet of Things
Artificial satellites serve various functions, such as communications, Earth observation, navigation, and global positioning. A satellite constellation is a group of satellites working together under centralized control to achieve a common objective. Positioned in complementary orbital planes and connected to global ground stations, these constellations aim to provide interconnected network capabilities for IoT communications. IoT communication satellites must effectively manage data frame repetitions, involving the capability to receive, process, and retransmit data from IoT devices operating in conditions of deficient coverage. IoT satellites prioritize compact form factors, simplicity, and scalability, aiming to support low-data-rate applications efficiently.
  • 199
  • 12 Mar 2024
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