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Topic Review
Peppercorn (Legal)
In legal parlance, a peppercorn is a metaphor for a very small cash payment or other nominal consideration, used to satisfy the requirements for the creation of a legal contract. It is featured in Chappell & Co Ltd v Nestle Co Ltd ( AC 87), which stated that "a peppercorn does not cease to be good consideration if it is established that the promisee does not like pepper and will throw away the corn". What is unusual about the term is that it came into the language when peppercorns were extremely expensive; coming, as they exclusively did, from the Dutch Moluccas. Yet today, the term is more-or-less synonymous with ”a pittance“ — something of minimal value.
  • 3.3K
  • 01 Nov 2022
Topic Review
Dental Poly(methyl methacrylate)-Based Resin
Poly(methyl methacrylate) (PMMA)-based resins have been conventionally used in dental prostheses owing to their good biocompatibility. However, PMMA-based resins have relatively poor mechanical properties. The filler was incorporated in the photocurable PMMA-based resin to improve the mechanical and physicochemical properties. The filler-loaded PMMA-based resin has the potential for use in dental restorative materials.
  • 3.3K
  • 25 Mar 2022
Topic Review
Spent Oil Bleaching Earths
Spent oil bleaching earth (SOBE) is a waste product obtained in the refining process of oil. It is estimated that 120 million tons of oil are processed with bleaching earth worldwide, generating 2.5 million tons of spent bleaching earth as residue. Moreover, the serious fire and contamination risks that arise during storage and disposal of spent bleaching earth require appropriate technical solutions. The current treatment of SOBE residue is not in line with the new circular economy policies promoted by the European Union, since in most cases it is disposed of in landfills. New technologies that allow oil recovery and treatment of the earths, aiming to convert them into useful products are then needed. 
  • 3.3K
  • 26 Jul 2021
Topic Review
Aestheticization of Violence
The aestheticization of violence in high culture art or mass media has been the subject of considerable controversy and debate for centuries. In Western art, graphic depictions of the Passion of Christ have long been portrayed, as have a wide range of depictions of warfare by later painters and graphic artists. Theater and, in modern times, cinema have often featured battles and violent crimes, while images and descriptions of violence have always been a part of literature. Margaret Bruder states that the aestheticization of violence in film is the depiction of violence in a "stylistically excessive", "significant and sustained way" in which audience members are able to connect references from the "play of images and signs" to artworks, genre conventions, cultural symbols, or concepts.
  • 3.3K
  • 15 Nov 2022
Topic Review
Nonparametric Limits of Agreement
The assessment of agreement in method comparison and observer variability analysis of quantitative measurements is usually done by the Bland-Altman Limits of Agreement, where the paired differences are implicitly assumed to follow a normal distribution. Whenever this assumption does not hold, the 2.5% and 97.5% percentiles are obtained by quantile estimation. In the literature, empirical quantiles have been used for this purpose. In this simulation study, we applied both sample, subsampling, and kernel quantile estimators as well as other methods for quantile estimation to sample sizes between 30 and 150 and different distributions of the paired differences. The performance of 15 estimators in generating prediction intervals was measured by their respective coverage probability for one newly generated observation. Our results indicated that sample quantile estimators based on one or two order statistics outperformed all the other estimators and can be used for deriving nonparametric Limits of Agreement. For sample sizes exceeding 80 observations, more advanced quantile estimators, such as the Harrell-Davis and estimators of Sfakianakis-Verginis type, which use all the observed differences, performed likewise well, but may be considered intuitively more appealing than simple sample quantile estimators that are based on only two observations per quantile.
  • 3.3K
  • 27 Oct 2020
Topic Review
Technologies for Big Data
Big data is growing so fast that current storage technologies and analytical tools are gradually feeling their inefficiencies not only to store and manage the valuable data but also to take full advantages of the opportunities and business insights that enormous data can offer. Since 2014, the concept of a data lake is increasingly becoming a popular solution among information leaders and big data-driven companies to deal with the challenges that brought about by big data. However, due to lacking of enough established best practices or related theories, some practitioners are still being kept outside the gate to a less risky implementation of a data lake. Besides, practitioners can hardly find any references which are free of bias, such as academic researches or reports, and are hardly able to support them with the reality of building a data lake at preset from an independent perspective.  
  • 3.3K
  • 06 Jun 2021
Topic Review
Descendants of the Bounty Mutineers
The descendants of the Bounty mutineers and their Tahitian consorts include the modern-day Pitcairn Islanders as well as a little less than half of the population of Norfolk Island. Their descendants also live in New Zealand, Australia, and the United States. Because of the scarcity of people on the island, many of the mutineers' children and grandchildren intermarried, with some marrying cousins and second cousins. Occasionally a new person would arrive on the island bringing with them a new surname (like the American Samuel Russell Warren, whose descendants still live on the island today).
  • 3.3K
  • 25 Oct 2022
Topic Review
Applications of Nanostructured Materials
In the last few decades, the vast potential of nanomaterials for biomedical and healthcare applications has been extensively investigated. Several case studies demonstrated that nanomaterials can offer solutions to the current challenges of raw materials in the biomedical and healthcare fields. The different nanoparticles and nanostructured material synthesis approaches were described.
  • 3.3K
  • 11 Apr 2022
Topic Review
Clinical Overview of Oral Cavity Cancer
Head and neck cancers are the 6th most common cancers in the United States and responsible for nearly 2% of all deaths related to cancer. Approximately 95% of all head and neck cancers are squamous cell carcinoma (SCC); of which, oral cavity SCC is the most common (excluding non-melanoma cutaneous cancers). The incidence of oral cavity cancer has gradually increased over the past 20 years. Globally, there were more than 375,000 new cases of oral cavity cancers (including cancers of the lip) and more than 175,000 deaths in 2020.
  • 3.3K
  • 10 Jan 2022
Topic Review
Stimuli-responsive materials
Smart or stimuli-responsive materials are an emerging class of materials used for tissue engineering and drug delivery. A variety of stimuli (including temperature, pH, redox-state, light, and magnet fields) are being investigated for their potential to change a material’s properties, interactions, structure, and/or dimensions. The specificity of stimuli response, and ability to respond to endogenous cues inherently present in living systems provide possibilities to develop novel tissue engineering and drug delivery strategies (for example materials composed of stimuli responsive polymers that self-assemble or undergo phase transitions or morphology transformations). Herein, smart materials as controlled drug release vehicles for tissue engineering are described, highlighting their potential for the delivery of precise quantities of drugs at specific locations and times promoting the controlled repair or remodeling of tissues.
  • 3.3K
  • 24 Jul 2020
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