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Topic Review
Ivermectin as Broad-Spectrum Host-Directed Antiviral
The small molecule macrocyclic lactone ivermectin, approved by the US Food and Drug Administration for parasitic infections, has received attention in the last eight years due to its exciting potential as an antiviral. It was identified in a high-throughput chemical screen as inhibiting recognition of the nuclear localizing Human Immunodeficiency Virus 1 (HIV-1) integrase protein by the host heterodimeric importin (IMP) α/β1 complex, and has since been shown to bind directly to IMPα to induce conformational changes that prevent its normal function in mediating nuclear import of key viral and host proteins. Excitingly, cell culture experiments show robust antiviral action towards HIV-1, dengue virus (DENV), Zika virus, West Nile virus, Venezuelan equine encephalitis virus, Chikungunya virus, Pseudorabies virus, adenovirus, and SARS-CoV-2 (COVID-19). Phase III human clinical trials have been completed for DENV, with >60 trials currently in progress worldwide for SARS-CoV-2.
  • 13.8K
  • 30 Sep 2020
Topic Review
White Flag
Flag White flags have had different meanings throughout history and depending on the locale.
  • 13.8K
  • 02 Nov 2022
Topic Review
Divide and Rule
Divide and rule (Latin: divide et impera), or divide and conquer, in politics and sociology is gaining and maintaining power by breaking up larger concentrations of power into pieces that individually have less power than the one implementing the strategy. The use of this technique is meant to empower the sovereign to control subjects, populations, or factions of different interests, who collectively might be able to oppose its rule. Niccolò Machiavelli identifies a similar application to military strategy, advising in Book VI of The Art of War (1521) (L'arte della guerra): a Captain should endeavor with every act to divide the forces of the enemy. Machiavelli advises that this act should be achieved either by making him suspicious of his men in whom he trusted, or by giving him cause that he has to separate his forces, and, because of this, become weaker. The maxim divide et impera has been attributed to Philip II of Macedon. It was utilised by the Roman ruler Julius Caesar and the French emperor Napoleon (together with the maxim divide ut regnes). The strategy, but not the phrase, applies in many ancient cases: the example of Aulus Gabinius exists, parting the Jewish nation into five conventions, reported by Flavius Josephus in Book I, 169–170 of The Jewish War (De bello Judaico). Strabo also reports in Geographica, 8.7.3 that the Achaean League was gradually dissolved when it became part of the Roman province of Macedonia, as the Romans treated the various states differently, wishing to preserve some and to destroy others. The strategy of division and rule has been attributed to sovereigns, ranging from Louis XI of France to the House of Habsburg. Edward Coke denounces it in Chapter I of the Fourth Part of the Institutes of the Lawes of England, reporting that when it was demanded by the Lords and Commons what might be a principal motive for them to have good success in Parliament, it was answered: "Eritis insuperabiles, si fueritis inseparabiles. Explosum est illud diverbium: Divide, & impera, cum radix & vertex imperii in obedientium consensu rata sunt." [You would be invincible if you were inseparable. This proverb, Divide and rule, has been rejected, since the root and the summit of authority are confirmed by the consent of the subjects.] In a minor variation, Sir Francis Bacon wrote the phrase "separa et impera" in a letter to James I of 15 February 1615. James Madison made this recommendation in a letter to Thomas Jefferson of 24 October 1787, which summarized the thesis of The Federalist#10: "Divide et impera, the reprobated axiom of tyranny, is under certain (some) qualifications, the only policy, by which a republic can be administered on just principles." In Perpetual Peace: A Philosophical Sketch by Immanuel Kant (1795), Appendix one, Divide et impera is the third of three political maxims, the others being Fac et excusa (Act now, and make excuses later) and Si fecisti, nega (If you commit a crime, deny it). Elements of this technique involve: Historically, this strategy was used in many different ways by empires seeking to expand their territories. Immanuel Kant was an advocate of this tactic, noting that "the problem of setting up a state can be solved even by a nation of devils" so long as they possess an appropriate constitution which pits opposing factions against each other with a system of checks and balances. The concept is also mentioned as a strategy for market action in economics to get the most out of the players in a competitive market.
  • 13.7K
  • 28 Nov 2022
Topic Review
Buddhism and Evolution
Evolution is not explicitly mentioned in the Tipitaka. As no major principles of Buddhism contradict it, many Buddhists tacitly accept the theory of evolution. Questions about the eternity or infinity of the universe at large are counted among the 14 unanswerable questions which the Buddha maintained were counterproductive areas of speculation. As such, many Buddhists do not think about these kinds of questions as meaningful for the Buddhist goal of relieving oneself and others from suffering. One does not need to know the origin of life in order to achieve enlightenment. Dalai Lama dismisses the element of randomness in the theory of evolution based on natural selection: Lopez elaborates that the process of Rebirth (into any of a large number of states of being including the human, any kind of animal and several types of supernatural being) is conditioned by karma (action of consciousness), which explains Dalai Lama's view. Buddhists believe the beginning of this world and of life is inconceivable since they have neither beginning nor end. Buddhists believe that the world was not created once upon a time, but that the world has been created millions of times every second and will continue to do so by itself and will break away by itself.
  • 13.7K
  • 05 Nov 2022
Topic Review
In-Vehicle Networks
Modern vehicles are no longer simply mechanical devices. Connectivity between the vehicular network and the outside world has widened the security holes that hackers can use to exploit a vehicular network. Controller Area Network (CAN), FlexRay, and automotive Ethernet are popular protocols for in-vehicle networks (IVNs) and will stay in the industry for many more years. However, these protocols were not designed with security in mind. They have several vulnerabilities, such as lack of message authentication, lack of message encryption, and an ID-based arbitration mechanism for contention resolution. Adversaries can use these vulnerabilities to launch sophisticated attacks that may lead to loss of life and damage to property. Thus, the security of the vehicles should be handled carefully. In this paper, we investigate the security vulnerabilities with in-vehicle network protocols such as CAN, automotive Ethernet, and FlexRay. A comprehensive survey on security attacks launched against in-vehicle networks is presented along with countermeasures adopted by various researchers. Various algorithms have been proposed in the past for intrusion detection in IVNs. However, those approaches have several limitations that need special attention from the research community. Blockchain is a good approach to solving the existing security issues in IVNs, and we suggest a way to improve IVN security based on a hybrid blockchain.
  • 13.6K
  • 15 Apr 2021
Topic Review
Impact of Nanotechnology
The impact of nanotechnology extends from its medical, ethical, mental, legal and environmental applications, to fields such as engineering, biology, chemistry, computing, materials science, and communications. Major benefits of nanotechnology include improved manufacturing methods, water purification systems, energy systems, physical enhancement, nanomedicine, better food production methods, nutrition and large-scale infrastructure auto-fabrication. Nanotechnology's reduced size may allow for automation of tasks which were previously inaccessible due to physical restrictions, which in turn may reduce labor, land, or maintenance requirements placed on humans. Potential risks include environmental, health, and safety issues; transitional effects such as displacement of traditional industries as the products of nanotechnology become dominant, which are of concern to privacy rights advocates. These may be particularly important if potential negative effects of nanoparticles are overlooked. Whether nanotechnology merits special government regulation is a controversial issue. Regulatory bodies such as the United States Environmental Protection Agency and the Health and Consumer Protection Directorate of the European Commission have started dealing with the potential risks of nanoparticles. The organic food sector has been the first to act with the regulated exclusion of engineered nanoparticles from certified organic produce, firstly in Australia and the UK, and more recently in Canada , as well as for all food certified to Demeter International standards
  • 13.6K
  • 18 Oct 2022
Topic Review
Plant Embryogenesis
Plant embryogenesis is a process that occurs after the fertilization of an ovule to produce a fully developed plant embryo. This is a pertinent stage in the plant life cycle that is followed by dormancy and germination. The zygote produced after fertilization must undergo various cellular divisions and differentiations to become a mature embryo. An end stage embryo has five major components including the shoot apical meristem, hypocotyl, root meristem, root cap, and cotyledons. Unlike animal embryogenesis, plant embryogenesis results in an immature form of the plant, lacking most structures like leaves, stems, and reproductive structures. However, both plants and animals pass through a phylotypic stage that evolved independently and that causes a developmental constraint limiting morphological diversification.
  • 13.6K
  • 28 Apr 2023
Topic Review
Nutritional Value of Fish
Fish are considered highly nutritious products of the aquaculture system due to the presence of well-balanced macronutrients such as proteins, lipids and micronutrients such as vitamins and minerals
  • 13.5K
  • 28 Nov 2022
Topic Review
Moon Man (Internet Meme)
Mac Tonight is a fictional character used in the marketing for McDonald's restaurants during the mid-1980s. Known for his crescent moon head, sunglasses and piano-playing, the character used the song "Mack the Knife" which was made famous in the United States by Bobby Darin. Throughout the campaign, Mac was portrayed by actor Doug Jones in his fourth Hollywood job. Originally conceived as a promotion to increase dinner sales by Southern California licensees, Mac Tonight's popularity led McDonald's to take it nationwide in 1987. Although McDonald's ceased airing the commercials and retired the character after settling a lawsuit brought by Darin's estate in 1989, the company reintroduced the character nineteen years later throughout Southeast Asia in 2007.
  • 13.4K
  • 24 Nov 2022
Topic Review
Mongol Conquest of Khwarezmia
The Mongol conquest of Khwarezmia (Persian: حمله مغول به خوارزم‎), or the Mongol invasion of Iran (Persia) (Persian: حمله مغول به ایران‎), from 1219 to 1221 marked the beginning of the Mongol conquest of the Islamic states. The Mongol expansion would ultimately culminate in the conquest of virtually all of Asia as well as parts of Eastern Europe, with the exception of Japan , the Mamluk Sultanate of Egypt, Siberia, and most of the Indian subcontinent and Southeast Asia. According to the Persian historian Minhaj-i-Siraj, Genghis Khan sent the ruler of the Khwarazmian Empire, Muhammad II, a message seeking trade and greeted him as his neighbor: "I am master of the lands of the rising sun while you rule those of the setting sun. Let us conclude a firm treaty of friendship and peace", or he said "I am Khan of the lands of the rising sun while you are sultan of those of the setting sun: Let us conclude a firm agreement of friendship and peace." The Mongols' original unification of all "people in felt tents", unifying the nomadic tribes in Mongolia and then the Turkomans and other nomadic peoples, had come with relatively little bloodshed, and almost no material loss. The Mongol wars with the Jurchens was known to Muhammad II and he agreed to this peace treaty. War between the Mongols and the Khwarazmian Empire started less than a year later, when a Mongol caravan and its envoys were massacred in the Khwarazmian city of Otrar. In the ensuing war, lasting less than two years, the Khwarazmian dynasty was destroyed and the Khwarazmian Empire was conquered.
  • 13.3K
  • 16 Nov 2022
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