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Cystic Fibrosis Human Organs-on-a-Chip

Cystic fibrosis human organs-on-a-chip can be used in patients with cystic fibrosis (CF). CF is an autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane regulator (CFTR) gene: the gene product responsible for transporting chloride and bicarbonate ions through the apical membrane of most epithelial cells.

571
08 Jul 2021

Topic Review

Czochralski Process

The Czochralski process is a method of crystal growth used to obtain single crystals of semiconductors (e.g. silicon, germanium and gallium arsenide), metals (e.g. palladium, platinum, silver, gold), salts and synthetic gemstones. The process is named after Polish scientist Jan Czochralski, who invented the method in 1915 while investigating the crystallization rates of metals. He made this discovery by accident: instead of dipping his pen into his inkwell, he dipped it in molten tin, and drew a tin filament, which later proved to be a single crystal. The most important application may be the growth of large cylindrical ingots, or boules, of single crystal silicon used in the electronics industry to make semiconductor devices like integrated circuits. Other semiconductors, such as gallium arsenide, can also be grown by this method, although lower defect densities in this case can be obtained using variants of the Bridgman-Stockbarger technique.

3.8K
24 Nov 2022

Topic Review

The D-10 is a Soviet 100 mm tank gun developed in late World War II. It originally equipped the SU-100 tank destroyers and was later selected for the T-55 tank, equipping these as late as 1979. On the T-55 the D-10 continues to be in active service in many countries.

2.8K
19 Oct 2022

Topic Review

The Daihatsu Rocky (Japanese: ダイハツ・ロッキー, Daihatsu Rokkī) is an automobile nameplate used by Daihatsu for their lineup of SUVs. The nameplate was originally used as a ladder frame-based mini SUV that was sold in Japan and some international markets between 1989 and 2002. It was gradually replaced by the introduction of Terios in 1997. Beginning in 2019, the Rocky nameplate returned to Japan as a subcompact crossover SUV that replaces the Be‣go and is also rebadged and sold under Toyota brand as the Toyota Raize (Japanese: トヨタ・ライズ, Toyota Raizu).

2.0K
27 Oct 2022

Topic Review

DAISY Digital Talking Book

DAISY (Digital Accessible Information SYstem) is a technical standard for digital audiobooks, periodicals and computerized text. DAISY is designed to be a complete audio substitute for print material and is specifically designed for use by people with "print disabilities", including blindness, impaired vision, and dyslexia. Based on the MP3 and XML formats, the DAISY format has advanced features in addition to those of a traditional audio book. Users can search, place bookmarks, precisely navigate line by line, and regulate the speaking speed without distortion. DAISY also provides aurally accessible tables, references and additional information. As a result, DAISY allows visually impaired listeners to navigate something as complex as an encyclopedia or textbook, otherwise impossible using conventional audio recordings. DAISY multimedia can be a book, magazine, newspaper, journal, computerized text or a synchronized presentation of text and audio. It provides up to six embedded "navigation levels" for content, including embedded objects such as images, graphics, and MathML. In the DAISY standard, navigation is enabled within a sequential and hierarchical structure consisting of (marked-up) text synchronized with audio. DAISY 2 was based on XHTML and SMIL. DAISY 3 is a newer technology, also based on XML, and is standardized as ANSI/NISO Z39.86-2005. The DAISY Consortium was founded in 1996 and consists of international organizations committed to developing equitable access to information for people who have a print disability. The consortium was selected by the National Information Standards Organization (NISO) as the official maintenance agency for the DAISY/NISO Standard.

879
09 Nov 2022

Topic Review

Dam siting is the study of site selection, a branch of decision making, which has the characteristics of multidisciplinary integration, involving decision making, and coordination, geographic information science, computer science, etc. Siting decisions are constantly iterated and updated as the discipline evolves, and the dam siting process will inevitably face more challenges.

1.3K
24 Aug 2021

Topic Review

Damage Detection in FRP-Reinforced Concrete Elements

Fiber-Reinforced Polymer (FRP) composites have emerged as a promising alternative to conventional steel reinforcements in concrete structures owing to their benefits of corrosion resistance, higher strength-to-weight ratio, reduced maintenance cost, extended service life, and superior durability.

135
12 Mar 2024

Topic Review

Damages in Hydraulic Turbines

Failure can be defined as any change in a machinery part or component that results in its inability to execute its intended function satisfactorily. Machines are the core of every production line. Failure of the equipment carries a huge cost, which is not limited to wasting money and time on directly repairing equipment, but also includes the cost of unused equipment and the cost of lost unemployment benefits. Kaplan turbines, as one of the well-known hydraulic turbines, are generally utilized worldwide for low-head and high-flow conditions. Any failure in each of the turbine components can result in long-term downtime and high repair costs.

943
25 Apr 2023

Topic Review

Damen Stan Patrol Vessel

The Dutch shipbuilding firm The Damen Group, designs and manufactures a wide variety of vessels, including a range of related patrol vessels known generally as the Damen Stan Patrol Vessels. The Damen Stan patrol vessel designs' names include a four digit code, where the first two digits are the vessel's length, in metres, and the second two digits are its width. Over a dozen nations have classes of vessels based on the Damen Stan 4207 patrol vessel design, which are 42 metres (138 ft) long and 7 metres (23 ft) wide. The United States Coast Guard's Sentinel class cutters, based on the Damen Stan 4708 patrol vessel design, are 47 metres (154 ft) long and 8 metres (26 ft) wide. In the late 1990s three 41 patrol vessels were built for service in the Dutch Antilles, and experience with those vessels informed the later designs of the 4207 and 4708. Rather than design vessels that were strictly for naval use, the underlying Damen Stan patrol vessel designs do not include weapons, or a sensor suite. The designs have been adapted for constabulary duties, and for fishery and environmental patrols. According to Sanjay Badri-Maharaj, of the -Institute for Defence Studies and Analyses, described how adding an autocannon and military class sensor suite to the USCG's Sentinel class boosted its cost per vessel from $20 million United States dollar to $65 million. In recent years Damen has developed Damen Stan patrol vessels based on their Sea Axe bow design. The Stan 4207 design are 42.8-metre (140 ft) patrol vessels. They are 7.1 metres (23 ft) wide, and can travel at 22 knots (41 km/h; 25 mph). They are designed to carry a complement of approximately a dozen. The Stan 4708 are 46.8 metres (154 ft) long, 8.11 metres (26.6 ft) wide, have a maximum speed of 23.8 knots (44.1 km/h; 27.4 mph), and carry a complement of 16-24.

729
29 Nov 2022

Topic Review

Damping Effect of Buckling-Restrained Braces

Modern cities are becoming more and more dependent on transportation with the rapid growth of the population and the development of the economy. As a traffic lifeline, once a bridge is damaged in an earthquake, traffic will be hindered, and restoring and rebuilding the bridge will take a long time, which will affect the daily life of drivers and locals. Therefore, bridge seismic problems cannot be ignored. One of the most widely used damping methods used to mitigate the seismic responses of bridges in recent years is the application of buckling-restrained braces (BRBs). Due to their stable mechanical properties, simple construction, and simple designs, BRBs are effective seismic dampers that are gradually being applied in the study of seismic bridges to improve their seismic capacities. With the development of engineering technology, the structure of BRBs is constantly being updated, and experimental and theoretical research on them has gradually attracted increasing attention.

478
07 Apr 2023

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