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Topic Review
Pharmaceutical Importance of Broccoli
Broccoli (Brassica oleracea L. var. italica) belongs to the Brassicaceae family and has more divided and stalked leaves. It has gained considerable attention due to its remarkable nutritional composition and numerous health benefits. The pharmaceutical importance of broccoli is widely known as antimicrobial, antioxidant, anticancer, immunomodulator, antidiabetic, hepatoprotective, cardioprotective, and anti-amnesic.
  • 256
  • 26 Jul 2023
Topic Review
Pharmaceutical Properties of Gabapentin
Gabapentin (GBP) is a common name for 1-(aminomethyl)cyclohexaneacetic acid (C9H17NO2, CAS Registry No. 60142-96-3), a GABA (γ-aminobutyric acid) derivative and a popular active pharmaceutical ingredient (API). It has a molecular weight of 171.34 and two pKa values of 3.68 and 10.70.
  • 84
  • 13 Mar 2024
Topic Review
Pharmacists and Medication Regimen Complexity
Medication regimen complexity (MRC) may influence health outcomes, such as hospitalisation, hospital readmission and medication adherence. Pharmacists have been referred to as health professionals with the opportunity to act on MRC reduction.
  • 348
  • 31 Aug 2021
Topic Review
Pharmacogenetic Testing
Pharmacogenomics is a study of how the genome background is associated with drug resistance and how therapy strategy can be modified for a certain person to achieve benefit. The pharmacogenomics (PGx) testing becomes of great opportunity for physicians to make the proper decision regarding each non-trivial patient that does not respond to therapy. Although pharmacogenomics has become of growing interest to the healthcare market during the past five to ten years the exact mechanisms linking the genetic polymorphisms and observable responses to drug therapy are not always clear. Therefore, the success of PGx testing depends on the physician’s ability to understand the obtained results in a standardized way for each particular patient. The review aims to lead the reader through the general conception of PGx and related issues of PGx testing efficiency, personal data security, and health safety at a current clinical level.
  • 564
  • 07 Jan 2021
Topic Review
Pharmacogenetics in Chronic Kidney Disease
Chronic kidney disease (CKD) is an important global public health problem due to its high prevalence and morbidity. Although the treatment of nephrology patients has changed considerably, ineffectiveness and side effects of medications represent a major issue. Pharmacogenetics could fill this gap.
  • 511
  • 28 Jul 2021
Topic Review
Pharmacogenetics of Antidepressants
Pharmacotherapy for neuropsychiatric disorders, such as depression, has been characterized by significant inter-individual variability in drug response and the development of side effects. Pharmacogenetics, as a key part of personalized medicine, aims to optimize therapy according to a patient’s individual genetic signature by targeting genetic variations involved in pharmacokinetic or pharmacodynamic processes. Pharmacokinetic variability refers to variations in a drug’s absorption, distribution, metabolism, and elimination, whereas pharmacodynamic variability results from variable interactions of an active drug with its target molecules.
  • 244
  • 29 May 2023
Topic Review
Pharmacogenomics Variability of Lipid-Lowering Therapies
The exponential expansion of genomic data coupled with the lack of appropriate clinical categorization of the variants is posing a major challenge to conventional medications for many common and rare diseases. To narrow this gap and achieve the goals of personalized medicine, a collaborative effort should be made to characterize the genomic variants functionally and clinically with a massive global genomic sequencing of “healthy” subjects from several ethnicities. Familial-based clustered diseases with homogenous genetic backgrounds are amongst the most beneficial tools to help address this challenge
  • 398
  • 11 Oct 2021
Topic Review
Pharmacokinetic Analysis of Ethanol in a Human Study
In the pharmacokinetic analysis of ethanol after oral administration, only single- or two-compartment models are used, but their precision in estimating pharmacokinetic parameters might be insufficient. Pharmacokinetic parameters obtained using pharmacokinetic models differ depending on the type of model used. The estimated pharmacokinetic parameters depend on the type of model used. The classic Widmark model in particular overestimated the fraction of absorbed ethanol from the gastrointestinal system to systemic circulation. 
  • 410
  • 23 Oct 2023
Topic Review
Pharmacokinetics of Tocotrienol
Tocotrienols are valuable nutraceuticals due to their numerous pharmacological properties, particularly in preventing or treating non-communicable diseases, including cardiovascular, musculoskeletal, metabolic, and skin disorders, as well as cancers.
  • 182
  • 13 Oct 2023
Topic Review
Pharmacokinetics/Pharmacogenetics in Atypical LAI Antipsychotics
Over the last two decades, pharmacogenetics and pharmacokinetics have been increasingly used in clinical practice in Psychiatry due to the high variability regarding response and side effects of antipsychotic drugs. Specifically, long-acting injectable (LAI) antipsychotics have different pharmacokinetic profile than oral formulations due to their sustained release characteristics. In addition, most of these drugs are metabolized by CYP2D6, whose interindividual genetic variability results in different metabolizer status and, consequently, into different plasma concentrations of the drugs. In this context, there is consistent evidence which supports the use of therapeutic drug monitoring (TDM) along with pharmacogenetic tests to improve safety and efficacy of antipsychotic pharmacotherapy. 
  • 490
  • 07 Jul 2021
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