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Topic Review
Exosome-Based Drug Delivery in Lupus
Exosomes are lipid-bilayer-enclosed extracellular vesicles released by many cell types in both normal and pathological conditions, and which transport nucleic acids, lipids and proteins between cells. Due to their suitable proprieties, as well as their known therapeutic effects, exosome-based nanocarriers have a bright future as next-generation drug delivery vehicles.
  • 623
  • 18 Mar 2021
Topic Review
Matrix Metalloproteinases
Matrix metalloproteinases (MMPs) are zinc-dependent proteases that have been extensively studied in the context of extracellular matrix (ECM) breakdown and remodelling.
  • 667
  • 18 Mar 2021
Topic Review
Honey in Reversing Metabolic Syndrome
Honey is a natural by-product from the flower nectar and aerodigestive tract of honey bees, which contains various complex biochemical components. Fructose (36%) and glucose (31%) are the main carbohydrate constituents of honey.
  • 797
  • 18 Mar 2021
Topic Review
Salvia divinorum
Salvia divinorum Epling and Játiva is a psychoactive Mexican mint used for centuries by Mazatec Indian shamans or curanderos of north-eastern Oaxaca, Mexico, for divinatory and religious purposes and physical healing.
  • 3.4K
  • 18 Mar 2021
Topic Review
Roxadustat
Roxadustat is the first oral drug in the class of new erythropoiesis drugs and a potent HIF-PHD inhibitor, exerted to treat anemia in patients with CKD. In phase 1, 2 and 3 studies with CKD-affected patients, roxadustat was more effective to stimulate erythropoiesis for anemia correction than previously used drugs. Roxadustat can be orally given, unlike other erythropoiesis drugs with parenteral administration only, which grants roxadustat a considerable advantage.
  • 848
  • 16 Mar 2021
Topic Review
Galectin-3
Galectin-3 is a member of the galectins family of carbohydrate-binding proteins with specificity for N-acetyllactosamine (LacNAc)-containing glycoproteins, and the only known one with a single carbohydrate recognition domain and a unique N-terminus.
  • 659
  • 16 Mar 2021
Topic Review
Angiotensin II Type 2 Receptor
Preclinical evidence, accumulated over the past decade, indicates that the angiotensin II type 2 receptor (AT2R) stimulation exerts significant neuroprotective effects in various animal models of neuronal injury, notably in the central nervous system.   Studies of brain AT2R distribution and function are outshining the recent findings about AT2R in peripheral sensoryneurons and pain modulation. While AT2R, as an atypical G protein-coupled receptor, and its related signaling are still under investigation, pharmacological studies have shown that stimulation of AT2R leads to neuritogenesis in vitro and in vivo. This review aims to report the evidence of potential neuroprotective and neuroregenerative roles of AT2R in the peripheral nervous system (PNS).
  • 1.0K
  • 10 Mar 2021
Topic Review
Cell-Free DNA
Cell-free DNA (cfDNA) testing, is an emerging “liquid biopsy” tool for noninvasive lymphoma detection, and an increased amount of data are now available to use this technique with accuracy, especially in classical Hodgkin lymphoma (cHL) and diffuse large B-cell lymphoma (DLBCL). The advantages of cfDNA include simplicity of repeated blood sample acquisition over time; dynamic, noninvasive, and quantitative analysis; fast turnover time; reasonable cost; and established consistency with results from tumor genomic DNA. cfDNA analysis offers an easy method for genotyping the overall molecular landscape of pediatric and adult cHL and may help in cases of diagnostic difficulties between cHL and other lymphomas.
  • 656
  • 10 Mar 2021
Topic Review
TG2 in Inflammation and Sepsis
Transglutaminase 2 (TG2) is a crosslinking enzyme that forms a covalent bond between lysine and glutamine. TG2 plays important roles in diverse cellular processes, including extracellular matrix stabilization, cytoskeletal function, cell motility, adhesion, signal transduction, apoptosis, and cell survival.
  • 424
  • 10 Mar 2021
Topic Review
CYP2D6 and Tamoxifen Metabolism
Tamoxifen is an important adjuvant endocrine therapy in estrogen receptor (ER)-positive breast cancer patients. It is metabolized into its most active antiestrogenic metabolite endoxifen, predominantly by cytochrome P450 2D6 (CYP2D6). Many factors, including genetic variation in CYP2D6, influence tamoxifen metabolism and pharmacokinetics.
  • 899
  • 09 Mar 2021
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