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Topic Review
Biography
Topic Review
Phytopharmaceutical Formulations and Other Uses of
Moringa oleifera
Moringa oleifera, also known as the “tree of life” or “miracle tree,” is classified as an important herbal plant due to its immense medicinal and non-medicinal benefits. The plant is used to cure wounds, pain, ulcers, liver disease, heart disease, cancer, and inflammation.
421
13 Feb 2023
Topic Review
Phytochemistry, Medicinal Uses and Pharmacological Activities of
Parkia
Parkia is a genus of flowering plants belonging to the family Fabaceae (subfamily, Mimosoideae) with pan-tropical distribution. The word Parkia was named after the Scottish explorer Mungo Park, who drowned in the Niger River, Nigeria in January 1805. The genus Parkia (Fabaceae, Subfamily, Mimosoideae) comprises about 34 species of mostly evergreen trees widely distributed across neotropics, Asia, and Africa.
438
10 Feb 2023
Topic Review
Citrus hystrix
DC for Metabolic Disorders
Metabolic disorder, which includes hypertension, diabetes mellitus, dyslipidemia, and obesity, represents a major global health concern due to increased morbidity and mortality. It occurs due to disturbance in normal metabolic process leading to redox and energy imbalance. Metabolic disorder, which includes hypertension, diabetes mellitus, dyslipidemia, and obesity, represents a major global health concern due to increased morbidity and mortality. It occurs due to disturbance in normal metabolic process leading to redox and energy imbalance.
648
10 Feb 2023
Topic Review
Trientine in Hypertrophic Cardiomyopathy
Trientine, a copper-chelating drug used in the management of patients with Wilson’s disease, demonstrates beneficial effects in patients with hypertrophic cardiomyopathy.
442
10 Feb 2023
Topic Review
Ivabradine Effects on Cardiac Function
Cardiac remodeling can cause ventricular dysfunction and progress to heart failure, a cardiovascular disease that claims many lives globally. Ivabradine, a funny channel (If) inhibitor, is used in patients with chronic heart failure as an adjunct to other heart failure medications.
432
10 Feb 2023
Topic Review
Advanced Drug Delivery for Treating Sjögren’s Dry Eye
Sjögren’s syndrome is a chronic and insidious autoimmune disease characterized by lymphocyte infiltration of exocrine glands. Patients typically present with dry eye (keratoconjunctivitis sicca), dry mouth (xerostomia), and other systemic manifestations. The current management for Sjögren's syndrome dry eye (SSDE) has been ineffective as it only targets ocular surface inflammation and dryness without addressing the specific disease process. Ophthalmologists often adopt a trial-and-error approach, which allows the cycle of dry eye disease (DED) to progress and potentially cause permanent damage to the lacrimal functional unit. Topical treatments also depend on patients' ability to administer eye drops and their compliance. These limitations emphasize the need for personalized, targeted treatments that address the underlying pathophysiology of SSDE. This article aims to present new advances in ocular drug delivery for more effective treatment.
536
10 Feb 2023
Topic Review
Pleiotropic Effects of Vitamin D in Inflammatory-Based Diseases
Numerous pleiotropic effects have been reported for vitamin D (vit D) since its discovery a century ago. Today it is well known that in addition to its pivotal role in calcium homeostasis and bone metabolism, vit D has antibacterial, anti-proliferative, immunomodulatory, and anti-inflammatory actions, among other beneficial properties. In the context of inflammatory-based diseases, vit D and its receptor VDR might fulfil their roles as gene regulators through direct gene regulation and epigenetic mechanisms.
380
10 Feb 2023
Topic Review
Biomedical Applications of Modified Dextran
Native DEX (Dextran) exhibits low-cell-adhesive properties and in order to obtain hydrogels with controlled cell-scaffold interactions, specific molecules must be incorporated. Many research groups have chemically modified DEX by introducing functional groups into the molecule through cross-linking reactions, therefore improving mechanical strength and drug-loading ability and increasing the number of compound classes that can be obtained. Furthermore, DEX has been shown to have metal chelating activity and antioxidant properties, as well as antitumour activity by regulating apoptosis and autophagy.
536
10 Feb 2023
Topic Review
Antitumour Activity of Natural Products Containing Isoxazole/Isoxazoline Moiety
Isoxazoles and isoxazolines are five-membered heterocyclic molecules containing nitrogen and oxygen. Isoxazole and isoxazoline are the most popular heterocyclic compounds for developing novel drug candidates. As biosynthetic technology has advanced, A growing number of natural products are being developed for cancer therapy as clinical candidates. As a result, scientists have created several isoxazole and isoxazoline derivatives with anti-cancer properties based on natural products.
542
09 Feb 2023
Topic Review
The Application of Smart Biomaterials in Diabetic Wounds
Diabetes mellitus is a complicated metabolic disease that has become one of the fastest-growing health crises in modern society. Diabetic patients may suffer from various complications, and diabetic foot is one of them. It can lead to increased rates of lower-extremity amputation and mortality, even seriously threatening the life and health of patients. Because its healing process is affected by various factors, its management and treatment are very challenging. To address these problems, smart biomaterials have been developed to expedite diabetic wound closure and improve treatment outcomes.
328
09 Feb 2023
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