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Topic Review
Quercetin a Natural Therapeutic Candidate
This manuscript was provided as a comprehensive review of the anti-influenza virus effect of quercetin and its derivatives with critical evaluation. We provided different classifications and focused on viral pathogenesis, animal models, human studies, in silico and docking studies and molecular pathways of quercetin and derivatives effects comprehensively which is not included in similar articles. This review is a multidisciplinary collection of cell biology, biotechnology, drug development, and virus investigation.
  • 1.1K
  • 11 Jan 2021
Topic Review
Biomedical Applications of Plant-Mediated Zinc Oxide Nanoparticles
Zinc oxide nanoparticles have become one of the most popular metal oxide nanoparticles and recently emerged as a promising potential candidate in the fields of optical, electrical, food packaging, and biomedical applications due to their biocompatibility, low toxicity, and low cost. They have a role in cell apoptosis, as they trigger excessive reactive oxygen species (ROS) formation and release zinc ions (Zn2+) that induce cell death. The zinc oxide nanoparticles synthesized using the plant extracts appear to be simple, safer, sustainable, and more environmentally friendly compared to the physical and chemical routes. These biosynthesized nanoparticles possess strong biological activities and are in use for various biological applications in several industries. Initially, the present review discusses the synthesis and recent advances of zinc oxide nanoparticles from plant sources (such as leaves, stems, bark, roots, rhizomes, fruits, flowers, and seeds) and their biomedical applications (such as antimicrobial, antioxidant, antidiabetic, anticancer, anti-inflammatory, photocatalytic, wound healing, and drug delivery), followed by their mechanisms of action involved in detail. 
  • 1.1K
  • 21 Oct 2021
Topic Review
Medicinal Value of Black Mulberry
Roughly 100 species of Morus have been described, such as Morus alba (white mulberry), Morus rubra (red mulberry), and Morus nigra (black mulberry). The mulberry plant is monoecious or dioecious, reaching up to 10–12 m in height. Morus nigra (Moraceae family) is commonly distributed in Asia, Africa, Europe, and America. Given its therapeutic properties, the leaves, root barks, branches, and fruits are traditionally used in medicinal preparations to manage diabetes mellitus, atherosclerosis, hyperlipidemia, and hypertension. Various extracts of mulberry leaves were studied over the years, investigating their bioactive compounds’ pharmaceutical in public health concerns, such as diabetes, hepatic diseases, and cardiovascular diseases. This entry is based on a literature review and highlights the beneficial and therapeutic action of black mulberry extracts and their confirmed or hypothesized mechanism of action in diabetes, hepatic disorders, and cardiovascular disease, as indicated by the results of in vivo and in vitro studies, on cell lines, human and animal models.
  • 1.1K
  • 10 May 2021
Topic Review
Antibiotics in Avian Species
Bacterial infections are commonly diagnosed and treated with antibiotics in the avian species. Infected birds can spread zoonotic diseases such as influenza, psittacosis, pasteurellosis, and campylobacteriosis to humans, especially if they are in close contact with them, such as pet-owner settings, zoos, or pet shops. The elimination of bacterial infections in birds is therefore important for both human and avian health.
  • 1.1K
  • 08 Jun 2022
Topic Review
Biological Barriers to Oral Drug Delivery Systems
The oral route is the most preferred route for systemic and local drug delivery. However, the oral drug delivery system faces the harsh physiological and physicochemical environment of the gastrointestinal tract, which limits the bioavailability and targeted design of oral drug delivery system.
  • 1.1K
  • 08 Feb 2023
Topic Review
Solvent Injection for SLNs/NLCs Preparation
A number of studies have used the solvent injection method to produce solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs), and various drugs have been loaded into these carriers for different applications. Here, we present major SLNs and NLCs systems and details of applications that use this method in 2006-2020. Furthermore, we discuss the effects of various parameters of solvent injection method on SLNs and NLCs production and propose some suggestions regarding future developments and applications.
  • 1.1K
  • 20 Apr 2021
Topic Review
Plants Secondary Metabolites
Plant secondary metabolites were reported to inhibit carbohydrate metabolizing enzymes, possess kinase activating capacity, thereby affecting all the metabolic pathways of carbohydrate, lipid and protein, and can intervene in the insulin-signaling pathway, inflammatory response, and oxidative stress and restore molecular aberrations leading to insulin resistance and glucose intolerance.
  • 1.1K
  • 09 Oct 2021
Topic Review
Spray Drying for Direct Compression
Direct compression is a simple, quick and cost-effective drug manufacturing approaches of tableting.
  • 1.1K
  • 25 Feb 2021
Topic Review
Cardiomyopathies
Cardiomyopathies are defined as cardiac diseases, in which the heart muscle is affected showing functional and structural defects.
  • 1.1K
  • 04 Feb 2021
Topic Review
Papaverine and Its Mechanism of Action
Papaverine has been proven to be a high-value opioid alkaloid in the field of therapeutics either in solitude or in combination with other metabolites/molecules. Pharmacological research has revealed that papaverine demonstrates a variety of biological activities, including activity against erectile dysfunction, postoperative vasospasms, and pulmonary vasoconstriction, as well as antiviral, cardioprotective, anti-inflammatory, anticancer, neuroprotective, and gestational actions.
  • 1.1K
  • 07 Apr 2023
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