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All Topic Review Biography
Topic Review
Current Application of DNSPEs in Drug Delivery
A drug nanocrystal self-stabilized Pickering emulsion (DNSPE) is a novel Pickering emulsion with drug nanocrystals as the stabilizer. As a promising drug delivery system, DNSPEs have attracted increasing attention due to their high drug loading capacity and ability to reduce potential safety hazards posed by surfactants or specific solid particles.
  • 140
  • 28 Feb 2024
Topic Review
Impact of Pharmacogenomics in Clinical Practice
Polymorphisms of genes encoding drug metabolizing enzymes and transporters can significantly modify pharmacokinetics, and this can be associated with significant differences in drug efficacy, safety, and tolerability. Moreover, genetic variants of some components of the immune system can explain clinically relevant drug-related adverse events. Knowledge of how genetic variations can modify the effectiveness, safety, and tolerability of a drug can lead to the adjustment of usually recommended drug dosages, improve effectiveness, and reduce drug-related adverse events. 
  • 138
  • 19 Jan 2024
Topic Review
Nano-Formulations for Pulmonary Delivery
With the development of nanotechnology and confronting the problems of traditional pharmaceutical formulations in treating lung diseases, inhalable nano-formulations have attracted interest. Inhalable nano-formulations for treating lung diseases allow for precise pulmonary drug delivery, overcoming physiological barriers, improving aerosol lung deposition rates, and increasing drug bioavailability. They are expected to solve the difficulties faced in treating lung diseases. 
  • 138
  • 07 Feb 2024
Topic Review
Development and Regulatory Approval of Biosimilars
Biological therapies have transformed high-burden treatments. As the patent and exclusivity period for biological medicines draws to a close, there is a possibility for the development and authorization of biosimilars. These products boast comparable levels of safety, quality, and effectiveness to their precursor reference products. Biosimilars, although similar to reference products, are not identical copies and should not be considered generic substitutes for the original. Their development and evaluation involve a rigorous step-by-step process that includes analytical, functional, and nonclinical evaluations and clinical trials. Clinical studies conducted for biosimilars aim to establish similar efficacy, safety, and immunogenicity, rather than demonstrating a clinical benefit, as with the reference product. 
  • 138
  • 29 Feb 2024
Topic Review
Multicomponent Mixtures and Single Compounds from Lentinula edodes
Apart from the isolation of single substances, complexly composed products, so-called multicomponent mixtures (more than one constituent substances, MOCSs), are obtained from the natural materials. A multicomponent mixture contains numerous individual constituents with different functionalities. By using the example of Lentinula edodes (Berk.) Pegler, shiitake, it is shown that this is the case not only for plants but also for medicinal mushrooms. Lentinan, a polysaccharide isolated from the mycelium, is used as a single compound as part of an integrated tumor therapy.
  • 138
  • 28 Feb 2024
Topic Review
Medical and Non-Medical USA Opioid Crisis
Drug overdose deaths in the USA rose from 16,849 in 1999 to nearly 110,000—of which an estimated 75,000 involved opioids—in 2022. On a yearly basis, the opioid casualty rate is higher than the combined number of victims of firearm violence and car accidents. The COVID-19 epidemic might have helped to worsen the addiction crisis in the USA by stimulating drug use among adolescents and diverting national attention to yet another public health crisis. So far, the failure to effectively respond to the opioid crisis is due to the gap between narcotic product regulation, regulation of marketing practices and the rise of a corporate-dominated health care system. 
  • 136
  • 12 Nov 2023
Topic Review
Cardioprotective Properties of Kaempferol
Cardiac diseases, such as myocardial infarction and heart failure, have become a major clinical problem globally. The accumulating data demonstrate that bioactive compounds with antioxidant and anti-inflammatory properties have favorable effects on clinical problems. Kaempferol is a flavonoid found in various plants; it has demonstrated cardioprotective properties in numerous cardiac injury models. 
  • 133
  • 11 Sep 2023
Topic Review
RNA Combined with Nanoformulation to Advance Therapeutic Technologies
Nucleic acid-based therapies have the potential to address numerous diseases that pose significant challenges to more traditional methods. RNA-based therapies have emerged as a promising avenue, utilizing nanoformulation treatments to target a range of pathologies. Nanoformulation offers several advantages compared to other treatment modalities, including targeted delivery, low toxicity, and bioactivity suitable for drug loading. Various types of nanoformulations are available, such as liposomes, polymeric nanoparticles (NPs), magnetic NPs, nanoshells, and solid lipid nanoparticles (SLNs). RNA-based therapy utilizes intracellular gene nanoparticles with messenger RNA (mRNA) emerging prominently in cancer therapy and immunotechnology against infectious diseases. The approval of mRNA-based technology opens doors for future technological advancements, particularly self-amplifying replicon RNA (repRNA). RepRNA is a novel platform in gene therapy, comprising viral RNA with a unique molecular property that enables the amplification of all encoded genetic information countless times. As a result, repRNA-based therapies have achieved significant levels of gene expression.
  • 130
  • 19 Dec 2023
Topic Review
Cultivation and Pharmacological Activities of Taxus mairei
Taxus mairei (Lemée and H.Lév.) S.Y.Hu, indigenous to the southern regions of China, is an evergreen tree belonging to the genus Taxus of the Taxaceae family. Owing to its content of various bioactive compounds, it exhibits multiple pharmacological activities and has been widely applied in clinical medicine.
  • 128
  • 14 Mar 2024
Topic Review
Off-Label Prescribing in Pediatric Population
Off-label prescribing is widespread among pediatricians, and it is unlikely that this trend will soon be bound by a uniform legal framework. This is necessitated by the fact that there are four variables: the patient’s health condition, the physician’s experience and knowledge, the legislative measures (laws, directives, guidelines, and recommendations), and finally, the pharmaceutical industry. There is considerable concern worldwide about the use of off-label medicines in children. 
  • 121
  • 06 Dec 2023
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