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Topic Review
Colchicine in Managing Skin Conditions
Colchicine is a natural alkaloid with anti-inflammatory properties used to treat various disorders, including some skin diseases. Colchicine could be, as a single therapy or in combination with other drugs, a possible treatment to manage several skin diseases.
  • 895
  • 13 Apr 2022
Topic Review
Chitosan/Graphene Oxide Composite Films
The healing of wounds is still one of the challenging clinical problems for which an efficient and fast treatment is needed. Therefore, recent studies have created a new generation of wound dressings which can accelerate the wound healing process with minimum side effects. Chitosan, a natural biopolymer, is an attractive candidate for preparing biocompatible dressings. The biodegradability, non-toxicity and antibacterial activity of chitosan have made it a promising biopolymer for treating wounds. Graphene oxide has also been considered by researchers as a non-toxic, inexpensive, and biocompatible material for wound healing applications. This review discusses the potential use of chitosan/graphene oxide composite films and their application in wound dressing and drug delivery systems. 
  • 889
  • 02 Sep 2021
Topic Review
The Role of Hormones in Hidradenitis Suppurativa
Hidradenitis suppurativa (HS) is a chronic inflammatory disease manifesting in inverse body regions. In HS, there appears to be a dysregulated adipokine release that is shifted towards pro-inflammatory adipokines. Insulin resistance is significantly more common in HS than in healthy patients regardless of BMI, age, and gender. Insulin resistance in HS patients leads to further cardiovascular disease. The mechanism of insulin resistance and role of adipokines should be investigated in future studies to better provide the pathomechanisms of HS. The role of androgens seems to be important in a certain subgroup of female patients. Anti-androgenic therapy can be useful and helpful in some patients.
  • 882
  • 19 Dec 2022
Topic Review
Management of Chronic Spontaneous Urticaria Using Anti-IgE Antibodies
Chronic spontaneous urticaria (CSU) considerably alters patients’ quality of life, often for extended periods, due to pruriginous skin lesions, impaired sleep, unexpected development of angioedema, and failure of conventional treatments in properly controlling signs and symptoms. Although the production of specific immunoglobulin E (IgE) antibodies against certain allergens is not a characteristic of the disease, treatment with omalizumab, a monoclonal anti-IgE antibody, proved efficient and safe in patients with moderate to severe chronic spontaneous urticaria uncontrolled by H1-antihistamines. Ligelizumab, a high-affinity monoclonal anti-IgE antibody, may also efficiently relieve symptoms of unresponsive chronic urticaria to standard therapies. 
  • 876
  • 27 Jul 2022
Topic Review
Microalgae Bioactive Compounds to Topical Applications Products
Microalgae are complex photosynthetic organisms found in marine and freshwater environments that produce valuable metabolites. Microalgae-derived metabolites have gained remarkable attention in different industrial biotechnological processes and pharmaceutical and cosmetic industries due to their multiple properties, including antioxidant, anti-aging, anti-cancer, phycoimmunomodulatory, anti-inflammatory, and antimicrobial activities. These properties are recognized as promising components for state-of-the-art cosmetics and cosmeceutical formulations.
  • 861
  • 13 Jun 2022
Topic Review
Acne Inversa
Acne inversa, namely, Hidradenitis suppurativa (HS), is a chronic inflammatory skin disease affecting ~1% of the global population. HS typically occurs after puberty, with the average age of onset in the second or third decades of life and with a female predominance. Approximately one third of patients are genetically predisposed. Moreover, lifestyle factors, such as smoking and obesity, play a crucial role in the clinical course of HS.
  • 826
  • 29 Sep 2021
Topic Review
Application of Silver in Medicine and Pharmacy
In the context of the growing resistance of microorganisms to available, widely used antibiotics, silver plays a key role. There is only one known case of bacterial resistance to silver—the Pseudomonas stutzeri strain, which naturally occurs in silver mines. The development of research in the field of coordination chemistry offers great opportunities in the design of new substances in which silver ions can be incorporated. 
  • 838
  • 06 Nov 2023
Topic Review
Psoriasis
Psoriasis is a common immune-mediated inflammatory skin disease characterized by well-demarcated scaly raised plaques.
  • 815
  • 22 Apr 2021
Topic Review
Superficial Spindle Cell Mesenchymal Tumors
Superficial spindle cell mesenchymal tumors form a diverse group of lesions with benign and malignant entities that are often very similar clinically and/or histologically. In children, the patient’s age; the lesion site; the presentation as a mass, nodule, or plaque; and the location in the dermis or subcutis are important features that will guide the dermatologist and the pathologist.
  • 801
  • 02 Oct 2021
Topic Review
Inflammation of the Lips (Cheilitis) and Perioral Skin
Lip inflammation may manifest as mainly reversible cheilitis, mainly irreversible, or cheilitis connected to dermatoses or systemic diseases. Therefore, knowing a patient’s medical history is important, especially whether their lip lesions are temporary, recurrent, or persistent. Sometimes temporary contributing factors, such as climate and weather conditions, can be identified and avoided—exposure to extreme weather conditions (e.g., dry, hot, or windy climates) may cause or trigger lip inflammation. Emotional and psychological stress are also mentioned in the etiology of some lip inflammations (e.g., exfoliative cheilitis) and may be associated with nervous habits such as lip licking. 
  • 795
  • 12 Jan 2023
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