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Topic Review
The Clinical Features and Diagnosis of Uremic Pruritus
Uremic pruritus, or chronic kidney disease-associated pruritus, is common, bothersome, and sometimes debilitating in patients with chronic kidney disease or end-stage renal disease. Due to its variable clinical manifestations, the diagnosis of uremic pruritus requires exquisite evaluation. Excluding itch resulting from other dermatological causes as well as other systemic conditions is essential for a proper diagnosis. The pathophysiology of uremic pruritus remains uncertain. Hypotheses including toxin deposition, immune system dysregulation, peripheral neuropathy, and opioid imbalance are supposed.
  • 433
  • 18 May 2022
Topic Review
Novel Treatments for Atopic Dermatitis
Atopic Dermatitis is a chronic, inflammatory skin disease characterized by strong pruritus that less commonly affects adults. This condition is associated with a poorer quality of life in comparison with the general population and causes sleep disturbances and coexisting comorbidities. Recently, new agents have been developed to treat this condition.
  • 430
  • 27 Dec 2021
Topic Review
Medical and Surgical Treatment of Hidradenitis Suppurativa
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease presenting with recurrent inflammatory lesions in intertriginous body regions. HS has a pronounced impact on patients’ quality of life and is associated with a variety of comorbidities. Treatment of HS is often complex, requiring an individual approach with medical and surgical treatments available.
  • 427
  • 16 Dec 2022
Topic Review
Contemporary Treatment Patterns in Relapsed/Refractory CTCL
The treatment pattern of cutaneous T-cell lymphoma (CTCL) remains diverse and patient-tailored. A European observational study provided real-world data on the current treatments used in the management of CTCL across three lines of therapy. As a result, there was a significant level of heterogeneity in treatment types than expected by European guidelines. 
  • 426
  • 06 Jan 2022
Topic Review
Response of Refractory Systemic Lupus Erythematosus to Anifrolumab
Systemic lupus erythematosus (SLE) is a clinically heterogeneous autoimmune disease, and organ manifestations, such as lupus nephritis (LN) or skin disease, may be refractory to standard treatment. Therefore, new agents are required to allow for a more personalized therapeutic approach. Several new therapies have been approved internationally, including voclosporine for LN and anifrolumab for moderately to severely active SLE. 
  • 425
  • 22 Jun 2022
Topic Review
Nanotechnology and Metal Nanoparticles for Wound Healing
Wound healing is an intricate physiological process consisting of a series of molecular and cellular events that facilitate the regeneration of the skin, a protective barrier against the external environment. Since its inception, hydrogels have advanced the field of wound healing, insofar as to promote damaged tissue healing within a hydrated milieu. As well, the integration of therapeutic nanoparticles (NP) and biomolecules into hydrogels for local wound application has been shown to enhance and accelerate healing. 
  • 425
  • 03 Aug 2023
Topic Review
Eosinophils and Basophils in Bullous Pemphigoid
Bullous pemphigoid (BP) is an autoimmune blistering skin disease, of which the incidence has increased in recent years. BP is characterized by circulating IgG and IgE autoantibodies against the hemidesmosomal proteins BP180 and BP230.
  • 424
  • 06 Jul 2023
Topic Review
Vitamin D and Non-Melanoma Skin Cancer
Non-melanoma skin cancers (NMSC) are the most common type of skin malignancies among humans (particularly fair-skinned populations of European descent) and its incidence rates have been on the rise globally for decades [1]. The best defined role of vitamin D in humans is in supporting the normal development and maintenance of bone tissues and in regulating calcium metabolism [7,8]. Furthermore, there is growing evidence that vitamin D plays a role in many fundamental biological processes (e.g., cell proliferation, angiogenesis, and modulation of the immune system) [9] implicated in carcinogenesis. 
  • 423
  • 26 Oct 2021
Topic Review
Psoriasis; Pathogenisis and green remedies
Although psoriasis remains one of the most devastating inflammatory disorders due to its huge negative impact on patients’ quality of life, new “green” treatment approaches still need to be fully explored.
  • 422
  • 11 Mar 2023
Topic Review
Light-based Treatments
Light-based treatments, chiefly photodynamic therapy and phototherapy, are currently applied in skin diseases. The current knowledge about the mechanisms of action of light-based treatments in skin diseases leans to the possible involvement of epigenetic and oxidative stress mechanisms. To better understand and exploit, to the fullest, these relatively safe and reproducible treatments, several studies have focused on miRNAs, small non-encoding RNAs (22–24 nucleotides), after light-based treatments.
  • 419
  • 11 Nov 2021
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