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Topic Review
Biography
Topic Review
SARS-CoV-2 Persistence
The recent pandemic caused by Sars-Cov-2 has caused a lot of confusion regarding containment protocols. Unfortunately, many of the characteristics of this virus are still unclear. The purpose of this article is to clarify what are the current notions regarding the persistence of the virus in the environment. Different factors were considered such as surfaces, temperature, humidity and pH; in relation to the inactivation time of the virus.
811
21 Sep 2020
Topic Review
Engineering Drug Delivery Systems
Engineering drug delivery systems (DDS) aim to release bioactive cargo to a specific site within the human body safely and efficiently. Hydrogels have been used as delivery matrices in different studies due to their biocompatibility, biodegradability, and versatility in biomedical purposes. Microparticles have also been used as drug delivery systems for similar reasons. The combination of microparticles and hydrogels in a composite system has been the topic of many research works. These composite systems can be injected in loco as DDS. The hydrogel will serve as a barrier to protect the particles and retard the release of any bioactive cargo within the particles. Additionally, these systems allow different release profiles, where different loads can be released sequentially, thus allowing a synergistic treatment. The reported advantages from several studies of these systems can be of great use in biomedicine for the development of more effective DDS.
811
04 Oct 2021
Topic Review
Cardiovascular Risk Stratification and Cancer
Cancer patients receiving a potentially cardiotoxic oncologic therapy have an increased risk of cardiovascular adverse events (CVAEs), especially in presence of concomitant arterial hypertension (AH). Therefore, cancer patients should be evaluated before, during and after cardiotoxic treatments, to early identify new-onset or worsening AH or CVAEs. An expert panel of oncology networks from Piedmont and Aosta Valley (North-Western Italy) aimed to provide recommendations to support health professionals in selecting the best management strategies for patients, considering the impact on outcome and the risk–benefit ratio of diagnostic/therapeutic tools.
811
28 Jan 2021
Topic Review
Growth Factors Regulation in Angiogenesis
Cardiovascular disease (CVD) remains a major cause of morbidity and mortality all over the world. Angiogenesis is controlled by cell–cell and cell-extracellular matrix (ECM) interactions through crosstalk between vascular endothelial growth factor (VEGF) and Notch signaling mechanisms.
811
31 May 2023
Topic Review
Vitamin K in Preventing Osteoarthritis
Cartilage calcification impairs the function of knee joints. Vitamin K can prevent cartilage calcification by regulating the carboxylation of matrix proteins, such as matrix gla protein. Prevention of calcium crystal formation also suppresses inflammation cytokines production by joint tissues.
811
30 Oct 2020
Topic Review
Wearable Sensors and Machine Learning for Hypovolemia Problems
Hypovolemia is a physiological state of reduced blood volume that can exist as either (1) absolute hypovolemia because of a lower circulating blood (plasma) volume for a given vascular space (dehydration, hemorrhage) or (2) relative hypovolemia resulting from an expanded vascular space (vasodilation) for a given circulating blood volume (e.g., heat stress, hypoxia, sepsis). The external environment and the user's level of physical activity can exacerbate hypovolemic challenges to the body. Noninvasive, wearable sensing systems are being developed to track a user's ability to compensate for these challenges.
811
13 Jan 2022
Topic Review
Deep Learning Applications in Tumor Pathology
The revolution of artificial intelligence and its impacts on our daily life has led to tremendous interest in the field and its related subtypes: machine learning and deep learning. Scientists and developers have designed machine learning- and deep learning-based algorithms to perform various tasks related to tumor pathologies, such as tumor detection, classification, grading with variant stages, diagnostic forecasting, recognition of pathological attributes, pathogenesis, and genomic mutations. Pathologists are interested in artificial intelligence to improve the diagnosis precision impartiality and to minimize the workload combined with the time consumed, which affects the accuracy of the decision taken.
811
15 Nov 2022
Topic Review
Sulforaphane
Sulforaphane (SFN) is a natural glucosinolate found in cruciferous vegetables that acts as a chemopreventive agent, but its mechanism of action is not clear. Due to antioxidative mechanisms being thought central in preventing cancer progression, SFN could play a role in oxidative processes. Since redox imbalance with increased levels of reactive oxygen species (ROS) is involved in the initiation and progression of bladder cancer, this mechanism might be involved when chemoresistance occurs.
810
02 Jul 2021
Topic Review
Yersinia Species
Yersinia spp. are non-spore-forming Gram-negative bacilli. They comprise only three species known to cause disease in humans, namely Y. pestis, Y. enterocolitica and Y. pseudotuberculosis. Since infective endocarditis (IE) is rarely caused by Yersinia, the management of these infections can be problematic due to the lack of experience.
810
25 Feb 2021
Topic Review
Bisphenol A in Related Pathological Conditions
Bisphenol A (BPA) is one of the so-called endocrine disrupting chemicals (EDCs) and is thought to be involved in the pathogenesis of different morbid conditions: immune-mediated disorders, type-2 diabetes mellitus, cardiovascular diseases, and cancer.
810
27 Mar 2023
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