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Topic Review
Anterior-Segment Optical-Coherence Tomography
Anterior-segment optical-coherence tomography (AS-OCT) is used to assess the iridocorneal angle and its alterations. The introduction of AS-OCT has led to improved assessments of the anatomy of the iridocorneal-angle and diagnoses of several mechanisms of angle closure which often result in raised intraocular pressure (IOP). Continuous advancements in AS-OCT technology and software, along with an extensive research in the field, have resulted in a wide range of possible parameters that may be used to diagnose and follow up on patients with this spectrum of diseases. However, the clinical relevance of such variables needs to be explored thoroughly.
  • 987
  • 14 Feb 2021
Topic Review
Lewy Body Dementia Mice Model
Lewy bodies are pathological characteristics of Lewy body dementia (LBD) and are composed of α-synuclein (α-Syn), which is mostly degraded via the ubiquitin–proteasome system. More importantly, 26S proteasomal activity decreases in the brain of LBD patients. 
  • 987
  • 22 Sep 2021
Topic Review
Arisaema Jacquemontii Blume
Arisaema jacquemontii Blume (Araceae) is a medicinally important plant and is used for the treatment of different diseases specially in dermatological disorders. Alkaloids, phenols, terpenes, flavonoids, glycosides, tannins have been reported from this plant. Antioxidant, antifungal, antibacterial and anticancer activities are also shown by Arisaema jacquemontii. 
  • 987
  • 15 Aug 2022
Topic Review
Chemotherapy-Induced Neuropathy and Diabetes
Diabetes mellitus and cancer are among the four most common chronic diseases, and are two of the leading causes of death worldwide [1]. Treatment of cancer patients with chemotherapy is influenced by multiple aspects, including neuropathy induced by chemotherapy drugs their self.
  • 986
  • 06 Oct 2021
Topic Review
Multiple Trace Theory
Multiple trace theory is a memory consolidation model advanced as an alternative model to strength theory. It posits that each time some information is presented to a person, it is neurally encoded in a unique memory trace composed of a combination of its attributes. Further support for this theory came in the 1960s from empirical findings that people could remember specific attributes about an object without remembering the object itself. The mode in which the information is presented and subsequently encoded can be flexibly incorporated into the model. This memory trace is unique from all others resembling it due to differences in some aspects of the item's attributes, and all memory traces incorporated since birth are combined into a multiple-trace representation in the brain. In memory research, a mathematical formulation of this theory can successfully explain empirical phenomena observed in recognition and recall tasks.
  • 986
  • 30 Sep 2022
Topic Review
Tumor-Associated Macrophages
Resident macrophage populations within tumors are termed tumor-associated macrophages (TAMs) and can comprise up to half of the tumor mass. In established solid malignancies, the anti-tumor functions of TAMs such as phagocytosis and cytotoxic activity are suppressed, and TAMs are subverted to facilitate tumor growth.
  • 986
  • 29 Mar 2022
Topic Review
Antibiotic Hybrids
An emerging strategy in the fight against antimicrobial resistance is the development of antibiotic hybrids. The term “hybrid” suggests a two-component molecule with biological activity that retains the activity of the individual components after hybridization, acting synergistically. For example, hybrid drugs that incorporate two active compounds into a single molecule could be used to expand the biological activity and prevent the development of bacterial resistance.
  • 986
  • 22 Sep 2022
Topic Review
Annona muricata and Its Anticancer Activity
Annona muricata is a member of the family Annonaceae and is familiar for its medicinal properties. A. muricata has been identified to have promising compounds that could potentially be utilized for the treatment of cancer. The most prevalent phytochemical components identified and isolated from this plant are alkaloids, phenols, and acetogenins.
  • 986
  • 14 Oct 2022
Topic Review
Optical Coherence Tomography (OCT) Findings
The main OCT biomarkers related to progression to advanced AMD include drusen volume, hyperreflective foci (HRF), reticular pseudodrusen or subretinal drusenoid deposits (SDD), incomplete retinal pigment epithelial and outer retinal atrophy (iRORA), hyper-transmission defects, and OCT-reflective drusen substructures (ODS).
  • 985
  • 07 Jan 2022
Topic Review
HRCT of Drug-Induced ILD
Interstitial Lung Diseases (ILDs) represent a heterogeneous group of pathologies, which may be related to different causes. A low percentage of these lung diseases may be secondary to the administration of drugs or substances. Several different high resolution computed tomography (HRCT) patterns related to pulmonary drug toxicity have been reported in literature, and the most frequent ILDs patterns reported include Nonspecific Interstitial Pneumonia (NSIP), Usual Interstitial Pneumonia (UIP), Hypersensitivity Pneumonitis (HP), Organizing Pneumonia (OP), Acute Respiratory Distress Syndrome (ARDS), and Diffuse Alveolar Damage (DAD). 
  • 985
  • 14 Jul 2021
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