Topic Review
Biological Melatonin versus Synthetic Melatonin
Melatonin dietary supplements are widely consumed worldwide, with developed countries as the largest consumers, with an estimated annual growth rate of approximately 10% until 2027, mainly in developing countries. The wide use of melatonin against sleep disorders and particular problems, such as jet lag, has been added to other applications, such as anti-aging, anti-stress, immune system activation, anticancer, and others, which have triggered its use, normally without a prescription. The chemical industry currently covers 100% of the needs of the melatonin market.
  • 1.4K
  • 18 Apr 2023
Topic Review
Zinc
Zinc is an important micronutrient and is required for cell proliferation, differentiation, growth, and development. It takes part in the maintenance of homeostasis, DNA synthesis, RNA transcription, cell division, and activation. It is also involved in immune responses, oxidative stress, apoptosis, and aging. Its deficiency was found to increase the levels of lipid peroxidation in the mitochondrial and microsomal membrane and the osmotic fragility of the erythrocyte membrane.
  • 1.3K
  • 25 Dec 2020
Topic Review
Molecular Detection of Colorectal Cancer
Drug-specific therapeutic approaches for colorectal cancer (CRC) have contributed to a significant improvement in the health status of patients. However, a great need to improve personalization of treatments based on genetic and epigenetic tumor profiles to maximize quality and efficacy while limiting cytotoxicity remains. Currently, CEA and CA 19-9 are the only validated blood biomarkers in clinical practice. For this reason, laboratories are trying to identify new specific prognostic and, more importantly, predictive biomarkers for CRC patient profiles. Thus, the unique landscape of personalized biomarker data should have a clinical impact on CRC treatment strategies and molecular genetic screening tests should become the standard method for CRC diagnosis, as well as detection of disease progression.
  • 1.4K
  • 30 Apr 2021
Topic Review
Cocaine
Cocaine is one of the most consumed stimulants throughout the world, as official sources report. It is a naturally occurring sympathomimetic tropane alkaloid derived from the leaves of Erythroxylon coca, which has been used by South American locals for millennia. Cocaine can usually be found in two forms, cocaine hydrochloride, a white powder, or ‘crack’ cocaine, the free base. 
  • 1.3K
  • 27 Apr 2022
Topic Review
Integrative Body Psychotherapy
Integrative body psychotherapy (IBP) is a psychotherapy that recognizes and treats the somatic (physical), psychological/emotional, and spiritual nature of a human being. It is based on the premise that the body, mind, and spirit are not separate, but rather integrated parts of a whole person. Every experience has a physical, mental, emotional, and spiritual aspect, which manifests internally within the body and externally in relationship to others. IBP was first developed by Jack Lee Rosenberg starting in the late 1970s (see § History, below).
  • 1.3K
  • 14 Oct 2022
Topic Review
Patient-Centered Care for Depression Patients
People have specific and unique individual and contextual characteristics, so healthcare should increasingly opt for person-centered care models. Care planning focused on people with depression and/or anxiety disorder must be individualized, dynamic, flexible, and participatory. It must respond to the specific needs of the person, contemplating the identification of problems, the establishment of individual objectives, shared decision making, information and education, systematic feedback, and case management, and it should meet the patient’s preferences and satisfaction with care and involve the family and therapeutic management in care.
  • 1.3K
  • 18 Aug 2021
Topic Review Peer Reviewed
Limbic Encephalitis Associated with COVID-19
Limbic encephalitis (LE) is an inflammatory disease of the brain, in which lesion is anatomically limited in structures of the limbic system. In some cases, LE can start with symptoms of limbic dysfunction with further involvement of other regions of the brain. Classic LE syndrome includes such symptoms as the development of personality disorders, depression, sleep disorders, epileptic seizures, hallucinations and cognitive disorders (short-term and long-term memory impairment). The information of clinical examination, electroencephalogram (EEG), magnetic resonance imaging (MRI) and cerebrospinal fluid studies (CSF) suggest the diagnosis of LE in most patients with Coronavirus Disease 2019 (COVID-19).
  • 1.3K
  • 13 Apr 2022
Topic Review
Nutrition in Elderly Cancer Therapy
The continuous increase in life expectancy results in a steady increase of cancer risk, which consequently increases the population of older adults with cancer. Older adults have their age-related nutritional needs and often suffer from comorbidities that may affect cancer therapy. They frequently are malnourished and present advanced-stage cancer. Therefore, this group of patients requires a special multidisciplinary approach to optimize their therapy and increase quality of life impaired by aging, cancer, and the side effects of therapy. Evaluation strategies, taking advantage of comprehensive geriatric assessment tools, including the comprehensive geriatric assessment (CGA), can help individualize treatment. As epigenetics, an emerging element of the regulation of gene expression, is involved in both aging and cancer and the epigenetic profile can be modulated by the diet, it seems to be a candidate to assist with planning a nutritional intervention in elderly populations with cancer.
  • 1.3K
  • 09 Nov 2020
Topic Review
Hyperferritinemia
Ferritin is one of the most frequently requested laboratory tests in primary and secondary care, and levels often deviate from reference ranges. Serving as an indirect marker for total body iron stores, low ferritin is highly specific for iron deficiency. Hyperferritinemia is, however, a non-specific finding, which is frequently overlooked in general practice. In routine medical practice, only 10% of cases are related to an iron overload, whilst the rest is seen as a result of acute phase reactions and reactive increases in ferritin due to underlying conditions. Differentiation of the presence or absence of an associated iron overload upon hyperferritinemia is essential, although often proves to be complex.
  • 1.3K
  • 27 May 2021
Topic Review
Treatment of Mental Disorders
Mental disorders are classified as a psychological condition marked primarily by sufficient disorganization of personality, mind, and emotions to seriously impair the normal psychological and often social functioning of the individual. Individuals diagnosed with certain mental disorders can be unable to function normally in society. Mental disorders may consist of several affective, behavioral, cognitive and perceptual components. The acknowledgement and understanding of mental health conditions has changed over time and across cultures. There are still variations in the definition, classification, and treatment of mental disorders.
  • 1.3K
  • 29 Nov 2022
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