Topic Review
Food Classification and Long-Tailed Image Recognition
Food classification serves as the basic step of image-based dietary assessment to predict the types of foods in each input image. However, foods in real-world scenarios are typically long-tail distributed, where a small number of food types are consumed more frequently than others, which causes a severe class imbalance issue and hinders the overall performance. In addition, none of the existing long-tailed classification methods focus on food data, which can be more challenging due to the inter-class similarity and intra-class diversity between food images. 
  • 416
  • 30 Jun 2023
Topic Review
Umbilical Cord-Derived Mesenchymal Stromal Cells in COVID-19 Treatment
Coronavirus disease 2019 (COVID-19), the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which counts more than 650 million cases and more than 6.6 million of deaths worldwide, affects the respiratory system with typical symptoms such as fever, cough, sore throat, acute respiratory distress syndrome (ARDS), and fatigue. Uumbilical-cord-derived mesenchymal stromal cells (UC-MSCs)  could be a potent tool against phlogistic status, not only during the last pandemic caused by SARS-CoV-2, but also for other future pandemic or respiratory tract inflammatory diseases. However, a series of challenges still lies ahead, comprising the accomplishment of all the tests required by the regulatory bodies.
  • 288
  • 30 Jun 2023
Topic Review
Lasers in Orthodontics
The orthodontics field is constantly looking for innovations to improve mechanical efficiency of tooth movement and patient's quality of life during treatment. New scientific reports on phototherapy and how it can optimize different stages of corrective treatment (before, during and after treatment) are discussed. Recurrent conditions that can be treated with lasers include removal of carious tissue, dentine hypersensitivity, and temporomandibular disorders. There is evidence that laser treatment optimize recovery, enabling the individual to start orthodontic treatment sooner. Along orthodontic interventions, photobiomodulation therapy is indicated for post-activation analgesia, repairing traumatic ulcers, and accelerating tooth movement. In addition, antimicrobial photodynamic therapy is also suitable for effective decontamination of oral infections such as herpes lesions and peri-implantitis. Finally, high-intensity lasers are a powerful ally in removing brackets and restoring the red aesthetics. The use of light sources in orthodontic routines has many advantages, including simplicity of technique, ease of handling of the appliance, minimal invasiveness, and patient comfort during the procedure. It is crucial that professionals develop a critical view of technological advances to provide safe, evidence-based treatments. Laser treatment improves the patient's experience during orthodontic treatment and minimizes side effects of clinical procedures.
  • 316
  • 30 Jun 2023
Topic Review
Smartphone Keystroke Dynamics for Understanding Neurocognitive Functioning
Can digital technologies provide a passive unobtrusive means to observe and study cognition outside of the laboratory? Previously, cognitive assessments and monitoring were conducted in a laboratory or clinical setting, allowing for a cross-sectional glimpse of cognitive states. 
  • 326
  • 30 Jun 2023
Topic Review
Microorganisms Affect Severe Combined Immunodeficiency Patients
Severe combined immunodeficiency (SCID) is a primary inherited immunodeficiency disease that presents before the age of three months and can be fatal. It is usually due to opportunistic infections caused by bacteria, viruses, fungi, and protozoa resulting in a decrease in number and impairment in the function of T and B cells. Microorganisms can affect SCID Patients' condition.
  • 298
  • 30 Jun 2023
Topic Review
Intestinal Barrier Dysfunction and Microbiota–Gut–Brain Axis
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with multifactorial etiology, characterized by impairment in two main functional areas: (1) communication and social interactions, and (2) skills, interests and activities. ASD patients often suffer from gastrointestinal symptoms associated with dysbiotic states and a “leaky gut.” A key role in the pathogenesis of ASD has been attributed to the gut microbiota, as it influences central nervous system development and neuropsychological and gastrointestinal homeostasis through the microbiota–gut–brain axis.
  • 565
  • 30 Jun 2023
Topic Review
Probiotics on Benign Gynaecological Disorders
Probiotics are live microorganisms that confer beneficial effects on human health when an adequate dose is administered. The use of probiotics has gained tremendous interest from the public due to its promising effects in the management of various reproductive diseases.
  • 447
  • 30 Jun 2023
Topic Review
Classical Hodgkin Lymphoma
Hodgkin lymphoma, a hematological malignancy of lymphoid origin that typically arises from germinal-center B cells, has an excellent overall prognosis. However, the treatment of patients who relapse or develop resistant disease still poses a substantial clinical and research challenge, even though current risk-adapted and response-based treatment techniques produce overall survival rates of over 95%. The appearance of late malignancies after the successful cure of primary or relapsed disease continues to be a major concern, mostly because of high survival rates. Particularly in pediatric HL patients, the chance of developing secondary leukemia is manifold compared to that in the general pediatric population, and the prognosis for patients with secondary leukemia is much worse than that for patients with other hematological malignancies.
  • 326
  • 30 Jun 2023
Topic Review
Membrane Transport Proteins in Cancer
The membrane transport and channel proteins are highly relevant for the use of pharmacological ascorbate in cancer therapy and are involved in the transfer of active substances such as ascorbate, hydrogen peroxide, and iron that predominantly must enter malignant cells to induce antiproliferative effects and especially ferroptosis.
  • 305
  • 30 Jun 2023
Topic Review
Irreversible Electroporation in Oncology
Locoregional therapies play an ever-increasing role in contemporary oncology. Researchers provide an up-to-date, informed analysis of locoregional therapies harnessing electric pulses. Irreversible electroporation (IRE), gene electrotransfer (GET), electrochemotherapy (ECT), calcium electroporation (Ca-EP), and tumour-treating fields (TTF) are integral to the therapeutic strategy in several solid tumours, ranging from skin cancers to visceral and bone metastases.
  • 387
  • 30 Jun 2023
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