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Topic Review
Newer HER2 Therapies for Gastric Adenocarcinomas
Human epidermal growth factor receptor-2 (HER2) is a well-known target for approximately 15% of gastric adenocarcinomas (GACs). Although a plethora of HER2-targeted agents are marketed, currently only two agents are approved for GAC. These two agents are used only in the metastatic setting. Trastuzumab is utilized in combination with front-line chemotherapy, and trastuzumab deruxtecan is given following failure of trastuzumab therapy.
  • 248
  • 31 Oct 2023
Topic Review
Monoclonal Antibody-Based First-Line Treatment in Gastric Cancer
Gastric cancer is the fifth most common malignancy worldwide and one of the main causes of cancer-related death. While surgical treatment is the only curative option for early disease, many have inoperable or advanced disease at diagnosis. Treatment in this case would be a combination of chemotherapy and immunotherapy. Gastro-esophageal (GEJ) and gastric cancer (GC) genetic profiling with molecular diagnostic techniques has significantly changed the therapeutic landscape in advanced cancers. The identification of key players in GEJ and GC survival and proliferation, such as human epidermal growth factor 2 (HER2), vascular endothelial growth factor (VEGF), and programmed cell death protein 1 (PD-1)/programmed cell death ligand-1 (PD-L1), has allowed for the individualization of advanced cancer treatment and significant improvement in overall survival and progression-free survival of patients. 
  • 318
  • 31 Oct 2023
Topic Review
Detection of Antibiotic-Resistant Bacteria
Antibiotic resistance is a global public health concern, posing a significant threat to the effectiveness of antibiotics in treating bacterial infections. The accurate and timely detection of antibiotic-resistant bacteria is crucial for implementing appropriate treatment strategies and preventing the spread of resistant strains.
  • 340
  • 31 Oct 2023
Topic Review
Huntington’s Disease Drug Development
Huntington’s Disease (HD) is a severely debilitating neurodegenerative disorder in which sufferers exhibit different combinations of movement disorders, dementia, and behavioral or psychiatric abnormalities. The disorder is a result of a trinucleotide repeat expansion mutation that is inherited in an autosomal dominant manner. While there is still no treatment to alter the course of HD, there are medications that lessen abnormal movement and psychiatric symptoms.
  • 210
  • 31 Oct 2023
Topic Review
Radiosurgery for Brain Metastases
Stereotactic radiosurgery (SRS) has transformed the management of brain metastases by achieving local tumor control, reducing toxicity, and minimizing the need for whole-brain radiation therapy (WBRT). Nevertheless, radiation treatment may induce brain changes, visible in neuroimaging, that are often difficult to distinguish from progressive disease.
  • 217
  • 31 Oct 2023
Topic Review
Smartphone Applications in Dentistry
Nowadays, smartphones are regularly used by people of all ages, and mobile health apps (MHAs) represent an important means of spreading information related to oral health, which is the state of the mouth and teeth, including the gums and other tissues. Several apps have been designed to promote prevention, diagnosis, and therapeutic adherence monitoring.
  • 290
  • 31 Oct 2023
Topic Review
Medical Therapies for Adenomyosis
Uterine Adenomyosis is a benign condition characterized by the presence of endometrium-like epithelial and stromal tissue in the myometrium. Several medical treatments have been proposed, but still, no guidelines directing the management of adenomyosis are available. While a hysterectomy is typically regarded as the definitive treatment for adenomyosis, the scarcity of high-quality data leaves patients desiring fertility with limited conservative options.
  • 188
  • 30 Oct 2023
Topic Review
Parkinson’s Disease and Cardiac 123I-MIBG
Cardiac sympathetic denervation, as documented on 123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy, is relatively sensitive and specific for distinguishing Parkinson’s disease (PD) from other neurodegenerative causes of parkinsonism. 
  • 396
  • 30 Oct 2023
Topic Review
In Vivo Organ/Tissue Genome Editing in Newborn Pups
Germline manipulation is based on gene delivery to early embryos, such as fertilized eggs (zygotes), through pronuclear microinjection of nucleic acids, electroporation (EP) in the presence of nucleic acids, or transduction in the presence of viral vectors.
  • 357
  • 30 Oct 2023
Topic Review
Clinical Approach to Immune Thrombocytopenia
Primary immune thrombocytopenia (ITP) is a complex autoimmune disease whose hallmark is a deregulation of cellular and humoral immunity leading to increased destruction and reduced production of platelets. The heterogeneity of presentation and clinical course hampers personalized approaches for diagnosis and management.
  • 284
  • 30 Oct 2023
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