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All Topic Review Biography
Topic Review
Promising Lead Compounds for Resistant-Tuberculosis
According to WHO report, globally about 10 million active tuberculosis cases, resulting in about 1.6 million deaths, further aggravated by drug-resistant tuberculosis and/or comorbidities. Incomplete therapeutic regimen, meager dosing, and the capability of the latent and/or active state tubercular bacilli to abide and do survive against contemporary first-line and second-line antitubercular drugs escalate the prevalence of drug-resistant tuberculosis. To explore and identify the most potential antitubercular drug candidate among various reported compounds, here we focused to highlight the promising lead derivatives of isoniazid, coumarin, griselimycin, and antimicrobial peptides. The aim of the present review is to fascinate significant lead compounds in the development of potential clinical drug candidates that might be more precise and effective against drug-resistant tuberculosis, the world research looking for a long time.
  • 981
  • 10 Dec 2020
Topic Review
Microvascular Tissue Engineering
Tissue engineering and regenerative medicine have come a long way in recent decades, but the lack of functioning vasculature is still a major obstacle preventing the development of thicker, physiologically relevant tissue constructs. A large part of this obstacle lies in the development of the vessels on a microscale—the microvasculature—that are crucial for oxygen and nutrient delivery. 
  • 981
  • 23 Jun 2021
Topic Review
Standard for Automated ECG Interpretation
Diagnostic statements for automated ECG interpretation algorithms are the fundamental output, and the accuracy of these statements should be well characterized by algorithm testing, including both ECG contour and ECG rhythm diagnostic statements. The methods for measuring accuracy have been consistently and well defined, and previously included in ECG standards. However, the current industry ECG standards have omitted these historical requirements to test the accuracy of diagnostic statements, which is a gap that is being addressed in 80601-2-86.
  • 980
  • 17 Sep 2021
Topic Review
Irinotecan
Irinotecan has been used in the treatment of various malignancies for many years. Still, the knowledge regarding this drug is expanding. The pharmacogenetics of the drug is the crucial component of response to irinotecan. Furthermore, new formulations of the drug are introduced for it enhanced delivery. Novel formulations of drugs (e.g., liposomal formulations, dendrimers, and nanoparticles) have a huge potential to avoid potentially life-threatening side effects of the iriniotecan. 
  • 980
  • 14 Jul 2020
Topic Review
Treating Traumatic Brain Injuries
Traumatic brain injury (TBI) is defined as an injury caused by an external force that results in the disruption of normal brain function. In the United States, between 2016–2017, there were approximately 451,000 cases of TBI that resulted in hospitalization. The most common mechanisms of injury contributing to TBI were unintentional falls and motor vehicle crashes.
  • 981
  • 05 Aug 2021
Topic Review
Colchicine in Managing Skin Conditions
Colchicine is a natural alkaloid with anti-inflammatory properties used to treat various disorders, including some skin diseases. Colchicine could be, as a single therapy or in combination with other drugs, a possible treatment to manage several skin diseases.
  • 979
  • 13 Apr 2022
Topic Review
ERK/MAPK Pathway in Gastric Cancer
Gastric Cancer (GC) is turning out today to be one of the most important welfare issues for both Asian and European countries. Indeed, while the vast majority of the disease burden is located in China and in Pacific and East Asia, GC in European countries still account for about 100.000 deaths per year. With this review article, we aimed to focus the attention on one of the most complex cellular pathways involved in GC proliferation, invasion, migration and metastasis: the MAP Kinases. Such large kinases family is to date constantly studied, since their discovery more than 30 years ago, due to the important role that it plays in the regulation of physiological and pathological processes. Interactions with other cellular proteins as well as miRNAs and lncRNAs may modulate their expression influencing the cellular biological features. Here, we summarize the most important and recent studies involving MAPK in GC. At the same time, we need to underlie that, differently from cancers arising from other tissues, where MAPK pathways seems to be a gold target for anticancer therapies, GC seems to be unique in any aspect. Our aim is to review the current knowledge in MAPK pathways alterations leading to GC, including H. pylori MAPK-triggering to derail from gastric normal epithelium to GC and to encourage researches involved in MAPK signal transduction, that seems to definitely sustain GC development.
  • 979
  • 28 Oct 2020
Topic Review
Excoriation Disorder
Excoriation disorder is an obsessive-compulsive spectrum mental disorder that is characterized by the repeated urge or impulse to pick at one's own skin to the extent that either psychological or physical damage is caused.
  • 979
  • 15 Nov 2022
Topic Review
Periodontitis and Systemic Disorder
Periodontitis, a major oral disease, affects a vast majority of the population but has been often ignored without realizing its long-fetched effects on overall human health. A realization in recent years of its association with severe diseases such as carditis, low birth weight babies, and preeclampsia has instigated dedicated research in this area. In the arena of periodontal medicines, the studies of past decades suggest a link between human periodontal afflictions and certain systemic disorders such as cardiovascular diseases, diabetes mellitus, respiratory disorders, preterm birth, autoimmune disorders, and cancer. Although, the disease appears as a locoregional infection, the periodontal pathogens, in addition their metabolic products and systemic mediators, receive access to the bloodstream, thereby contributing to the development of systemic disorders. Mechanism-based insights into the disease pathogenesis and association are highly relevant and shall be useful in avoiding any systemic complications.
  • 979
  • 30 Sep 2021
Topic Review
Rostering in Air Traffic Control
Most Air Traffic Controllers (ATCOs) must cover uninterrupted work shifts for 24 h a day, seven days a week. The proper planning of a shift schedule requires consideration of at least three elements: the specific characteristics of the controller task, the physiological needs of the operator, and the definition of rest periods within rostering.
  • 979
  • 19 May 2022
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