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All Topic Review Biography
Topic Review
Immunotherapy for Malignant Pleural Mesothelioma
Malignant pleural mesothelioma (MPM) is a locally aggressive disease related to asbestos exposure with a median survival for untreated patients of 4–8 months. The growing research in the field of MPM has culminated in the approval of new therapies that improve patient survival. New combinations of immunotherapy with chemotherapy could further improve patient outcomes.
  • 177
  • 08 Jan 2024
Topic Review
Chondroitin Sulphate Based Nanoparticle Production
Joint damage is a major symptom of osteoarthritis, a degenerative disease that worsens over time. Due to its poor regenerative and self-healing properties, cartilage repair after lesions or debilitating disease is a major clinical issue.
  • 122
  • 08 Jan 2024
Topic Review
TAMs and PD-1 Networking in Gastric Cancer
Gastric cancer (GC) is one of the most common and aggressive types of cancer. Immune checkpoint inhibitors (ICIs) have proven effective in treating various types of cancer. The use of ICIs in GC patients is currently an area of ongoing research. The tumor microenvironment (TME) also seems to play a crucial role in cancer progression. Tumor-associated macrophages (TAMs) are the most abundant population in the TME. TAMs are capable of displaying programmed cell death protein 1 (PD-1) on their surface and can form a ligand with programmed death ligand 1 (PD-L1), which is found on the surface of cancer cells. Therefore, it is expected that TAMs may significantly influence the immune response related to immune checkpoint inhibitors (ICIs).
  • 107
  • 08 Jan 2024
Topic Review
Applications of 3D Printing in Dentistry
3D printing technologies include stereolithography, digital light processing, fused deposition modeling, selective laser sintering/melting, photopolymer jetting, powder binder, and 3D laser bioprinting. The main categories of 3D printing materials are polymers, metals, and ceramics. Despite limitations in printing accuracy and quality, 3D printing technology is now able to offer people a wide variety of potential applications in different fields of dentistry, including prosthodontics, implantology, oral and maxillofacial, orthodontics, endodontics, and periodontics. Understanding the existing spectrum of 3D printing applications in dentistry will serve to further expand its use in the dental field. Three-dimensional printing technology has brought about a paradigm shift in the delivery of clinical care in medicine and dentistry. 
  • 208
  • 08 Jan 2024
Topic Review
Inferior Mesenteric Artery Ligation Level in Rectal-Cancer Surgery
Within the intricate field of rectal cancer surgery, the contentious debate over the optimal level of ligation of the inferior mesenteric artery (IMA) persists as an ongoing discussion, influencing surgical approaches and patient outcomes.
  • 133
  • 08 Jan 2024
Topic Review
Pulmonary Hypertension Screening Methods for ILD Patients
Heightened suspicion for pulmonary hypertension (PH) arises when the advancement of dyspnoea in interstitial lung disease (ILD) patients diverges from the expected pattern of decline in pulmonary function parameters. The complexity of PH associated with ILD (PH-ILD) diagnostics is emphasized by the limitations of transthoracic echocardiography in the ILD population, necessitating the exploration of alternative diagnostic approaches. Cardiac magnetic resonance imaging (MRI) emerges as a promising tool, offering insights into hemodynamic parameters and providing valuable prognostic information. The potential of biomarkers, alongside pulmonary function and cardiopulmonary exercise tests, is explored for enhanced diagnostic and prognostic precision.
  • 143
  • 08 Jan 2024
Topic Review
New Settings of CAR-T Cell Therapy for Lymphoma
Anti-CD19 chimeric antigen receptor (CAR)-T cell therapy has led to a treatment paradigm shift for B-cell non-Hodgkin lymphomas, first with the approval for relapsed/refractory (R/R) large B-cell lymphomas and subsequently for R/R mantle cell and follicular lymphoma. Many efforts are continuously being made to extend the therapeutic setting in the lymphoma field. Several reports are supporting the safety and efficacy of CAR-T cells in patients with central nervous system disease involvement. Anti-CD30 CAR-T cells for the treatment of Hodgkin lymphoma are in development and early studies looking for the optimal target for T-cell malignancies are ongoing. Anti-CD19/CD20 and CD19/CD22 dual targeting CAR-T cells are under investigation in order to increase anti-lymphoma activity and overcome tumor immune escape. Allogeneic CAR product engineering is on the way, representing a rapidly accessible ‘off-the-shelf’ and potentially more fit product. 
  • 138
  • 08 Jan 2024
Topic Review
Pharmacokinetics-Pharmacodynamics of Surgical Antimicrobial Prophylaxis
Appropriate surgical antimicrobial prophylaxis (SAP) is an important measure in preventing surgical site infections (SSIs). Although antimicrobial pharmacokinetics–pharmacodynamics (PKPD) is integral to optimizing antibiotic dosing for the treatment of infections, there is less research on preventing infections postsurgery. Whereas clinical studies of SAP dose, preincision timing, and redosing are informative, it is difficult to isolate their effect on SSI outcomes. Antimicrobial PKPD aims to explain the complex relationship between antibiotic exposure during surgery and the subsequent development of SSI. It accounts for the many factors that influence the PKs and antibiotic concentrations in patients and considers the susceptibilities of bacteria most likely to contaminate the surgical site. 
  • 184
  • 08 Jan 2024
Topic Review
Virtual Reality for Rehabilitation of Acquired Cognitive Disorders
Virtual Reality (VR) is presented as a transformative tool that immerses individuals in interactive environments, offering promising opportunities for enhancing cognitive functions and improving quality of life.
  • 175
  • 05 Jan 2024
Topic Review
Chemistry and Radiochemistry of DOTAZOL
Bisphosphonates are therapeutic agents that have been used for almost five decades in the treatment of various bone diseases, such as osteoporosis, Paget disease and prevention of osseous complications in cancer patients. In nuclear medicine, simple bisphosphonates such as 99mTc-radiolabelled oxidronate and medronate remain first-line bone scintigraphic imaging agents for both oncology and non-oncology indications. In addition, bifunctional bisphosphonates such as DOTAZOL can be tagged with radiometals for theranostic applications.
  • 230
  • 05 Jan 2024
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