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All Topic Review Biography
Topic Review Peer Reviewed
Traumatic Optic Neuropathy: Update on Management
Traumatic optic neuropathy is one of the causes of visual loss caused by blunt or penetrating head trauma and is classified as both direct and indirect. Clinical history and examination findings usually allow for the diagnosis of traumatic optic neuropathy. There is still controversy surrounding the management of traumatic optic neuropathy; some physicians advocate observation alone, while others recommend steroid therapy, surgery, or both. In this entry, researchers tried to highlight traumatic optic neuropathy’s main pathophysiologic mechanisms with the most available updated treatment. Recent research suggests future therapies that may be helpful in traumatic optic neuropathy cases.
  • 585
  • 13 Jan 2023
Topic Review
Traumatic Cerebral Haemorrhage
Traumatic brain injury (TBI) remains a major cause of death and disability worldwide. For all ages and TBI severities, crude incidence rates ranged from 47.3 to 694 per 100,000 population per year (country-level studies) and from 83.3 to 849 per 100,000 population per year (regional-level studies).
  • 395
  • 07 Feb 2022
Topic Review
Traumatic Cardiac Arrest
A paradigm shift in traumatic cardiac arrest (TCA) perception switched the traditional belief of futility of TCA resuscitation to a more optimistic perspective, at least in selected cases. The goal of TCA resuscitation is to rapidly and aggressively treat the common potentially reversible causes of TCA. Advances in diagnostics and therapy in TCA are ongoing; however, they are not always translating into improved outcomes. Further research is needed to improve outcome in this often young and previously healthy patient population.
  • 164
  • 26 Jan 2024
Topic Review
Traumatic Brain Injury and Secondary Neurodegenerative Disease
Traumatic brain injury (TBI) is a devastating event with severe long-term complications. TBI and its sequelae are one of the leading causes of death and disability in those under 50 years old. It is clear that neurotrauma can incite chronic neurodegenerative processes. Chronic traumatic encephalopathy, Parkinson’s disease, and many other neurodegenerative syndromes have all been associated with a history of traumatic brain injury. 
  • 319
  • 11 Oct 2022
Topic Review
Traumatic Brain Injury
Traumatic brain injury (TBI) is a major health concern worldwide and is classified based on severity into mild, moderate, and severe. The mechanical injury in TBI leads to a metabolic and ionic imbalance, which eventually leads to excessive production of reactive oxygen species (ROS) and a state of oxidative stress. To date, no drug has been approved by the food and drug administration (FDA) for the treatment of TBI. Nevertheless, it is thought that targeting the pathology mechanisms would alleviate the consequences of TBI. For that purpose, antioxidants have been considered as treatment options in TBI and were shown to have a neuroprotective effect. Of these, edaravone and mitoquinone seem to be promising. 
  • 835
  • 21 Oct 2020
Topic Review
Traumatic Brain Injuries Biomarkers in Sports-Related Context
Traumatic brain injury (TBI) affects 69 million people every year. One of the main limitations in managing TBI patients is the lack of univocal diagnostic criteria, including the absence of standardized assessment methods and guidelines. Immediacy and accuracy in diagnosis and management of TBIs are critically unmet medical needs. Especially in the context of sports-associated TBI, there is a strong need for prognostic indicators to help diagnose and identify at-risk subjects to avoid their returning to play while the brain is still highly vulnerable. Fluid biomarkers may emerge as new prognostic indicators to develop more accurate prediction models, improving risk stratification and clinical decision-making.
  • 291
  • 18 Apr 2023
Topic Review
Traumatic Brachial Plexus
Traumatic brachial plexus injuries are rare but serious consequences of major traumas. Pre-ganglionic lesions are considered irreparable, while post-ganglionic injuries can be potentially treated if an early diagnosis is available.
  • 597
  • 18 Feb 2021
Topic Review
Traumatic Axonal Injury in Concussion
Traumatic axonal injury (TAI) indicates the tearing of axons by indirect shearing forces during acceleration, deceleration, and rotation of the brain or direct head trauma. Since the 1960s, histopathological ones after autopsy have revealed TAI in patients with concussion who died from other causes. The diagnosis of TAI in live patients with concussion is limited because conventional brain MRI is not sensitive to detecting TAI in concussion.
  • 339
  • 02 Jun 2022
Topic Review
Trauma-Related Thoracic Outlet Syndrome
Thoracic outlet syndrome (TOS) is a group of symptoms that result from compression of the neurovascular bundle that exits the thoracic outlet. The thoracic outlet is defined as an anatomical area in the lower neck, extended from the supraclavicular fossa to the axilla, and consists of three main spaces, the interscalene triangle, the costoclavicular, and the subcoracoid space. These confined spaces go through relevant structures, which include the subclavian and axillary arteries, their venous counterparts, and the brachial plexus (BP).
  • 162
  • 07 Nov 2023
Topic Review
Trauma Systems Therapy
Trauma Systems Therapy (TST) is a mental health treatment model for children and adolescents who have been exposed to trauma, defined as experiencing, witnessing, or confronting "an event or events that involved actual or threatened death or serious injury, or a threat to the physical integrity of self or others". TST focuses on the child's emotional and behavioral needs as well as the environments where the child lives (home, school, community). The treatment model includes four components (skill-based psychotherapy, home and community-based care, advocacy, and psychopharmacology) that are fully described in a published manual. A clinical trial showed that TST is effective in improving the mental health and well-being of children who have been traumatized. TST has also been successfully replicated. TST is not just for victims, but also educates the victims' significant others in order for them to support the victims in their recovery and help them control their emotions during future stressful events. When referring to TST, therapists analyze four categories: the reason a child may need TST, the signs and symptoms expressed by the child, the management and treatment methods and the results of children who have gone through TST. A look at what causes emotional trauma, the families involved, and how therapy can heal the child as well as the adult are also important factors.
  • 379
  • 11 Nov 2022
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