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Topic Review
Genetics of Pustular Psoriasis
Psoriasis is a chronic inflammatory skin disease characterized by the appearance of clearly demarcated erythematous and scaly plaques. It can be divided into various types, including plaque, nail, guttate, inverse, and pustular psoriasis. Plaque psoriasis is the most commonly occurring type, though there is another rare but severe pustular autoinflammatory skin disease called generalized pustular psoriasis (GPP), which manifests with acute episodes of pustulation and systemic symptoms.
  • 247
  • 28 Jun 2023
Topic Review
Endoscopic Vacuum Therapy in the Upper Gastrointestinal Tract
Anastomotic leaks after gastrointestinal surgery have an important impact on surgical outcomes because of the high morbidity and mortality rates. Multiple treatment options exist requiring an individualized patient-tailored treatment plan after multidisciplinary discussion. Endoscopic vacuum therapy (EVT) is a novel treatment option that is nowadays recognized as an effective and useful endoscopic approach to treat leaks or perforations in both the upper and lower gastrointestinal tract.
  • 353
  • 28 Jun 2023
Topic Review
Trans-Regulatory KLF14 Gene
Krüpple-Like family of transcription factor-14 (KLF14) is a master trans-regulatory gene that has multiple biological regulatory functions and is involved in many pathological mechanisms. It controls the expressions of several other genes which are involved in multiple regulatory functions. 
  • 370
  • 28 Jun 2023
Topic Review
Adenoids and Tonsils: Immune System's Tireless Gatekeepers
Within the intricate realm of the mucosal immune system resides a captivating duo: the adenoids (or pharyngeal tonsils) and the tonsils (including palatine, tubal, and lingual variations), which harmoniously form the Waldeyer’s ring. As they are strategically positioned at the crossroads of the respiratory and gastrointestinal systems, these exceptional structures fulfill a vital purpose. They function as formidable “gatekeepers” by screening microorganisms—both bacteria and viruses—with the mission to vanquish local pathogens via antibody production. However, under specific circumstances, their function can take an unsettling turn, inadvertently transforming them into reservoirs for pathogen incubation.
  • 531
  • 28 Jun 2023
Topic Review
Mediterranean Diet and Male Fertility
Diet has an impact on male reproductive potential, but few studies have focused on the specific impact of food groups or dietary patterns on fertility. Male reproductive health, as indicated by improved semen parameters and increased chances of conceiving, is associated with the Mediterranean diet, while the Western diet is considered a risk factor for male infertility.
  • 495
  • 28 Jun 2023
Topic Review
Dimethyltryptamine
Dimethyltryptamine (DMT) is an indole alkaloid and a derivative of tryptamine (a metabolite of the essential amino acid tryptophan), which exists in many biological systems (endogenous substance) including plants and animals. DMT produces intense but short-lived (up to 30–60 min) psychedelic and hallucinogenic experiences. There is also increasing evidence that endogenous DMT plays a role in the central (CNS) and peripheral nervous system (PNS), and it may act as a neurotransmitter by acting as a non-selective serotonin agonist principally on the 5-hydroxytryptamine (5-HT1A and 5-HT2A) receptors.
  • 774
  • 27 Jun 2023
Topic Review
Diagnosis and Treatment of Endometrial Cancer
The incidence and death rates of endometrial cancer are rising globally. International guidelines recommend radical hysterectomy and bilateral salpingo-oophorectomy as the standard of care for this cancer; however, fertility-sparing alternatives should be tailored to motivated women of reproductive age, establishing an appropriate cost–benefit balance between childbearing desire and cancer risk. New molecular classifications such as that of The Cancer Genome Atlas (TCGA) provide a robust supplementary risk assessment tool that can tailor the treatment options to the patient’s needs, curtail over- and under-treatment, and contribute to the spread of fertility-preserving strategies.
  • 227
  • 27 Jun 2023
Topic Review
Lipid Abnormalities in Cerebrotendinous Xanthomatosis
Cerebrotendinous xanthomatosis (CTX) is an autosomal recessive disorder caused by pathogenic variants in CYP27A1, leading to a deficiency in sterol 27-hydroxylase. This defect results in the accumulation of cholestanol and bile alcohols in various tissues, including the brain, tendons, and peripheral nerves. Elevated levels of cholestanol are consistently observed. Most patients present normal or low serum cholesterol levels. The decrease in chenodeoxycholic acid (CDCA) leads to increased synthesis of cholesterol metabolites such as bile alcohols 23S-pentol and 25-tetrol 3-glucuronide, which may serve as surrogate follow-up markers in patients with CTX. Lipid abnormalities in CTX have clinical implications. Cholestanol deposition in tissues contributes to the clinical manifestations, including neurological symptoms and tendon xanthomas. Dyslipidemia and abnormal cholesterol metabolism may also contribute to the increased risk of atherosclerosis and cardiovascular complications observed in some CTX patients.
  • 300
  • 27 Jun 2023
Topic Review
The Diagnosis of Community-Acquired Pneumonia
Community-acquired pneumonia (CAP) is among the most common causes of death and one of the leading healthcare concerns worldwide. It can evolve into sepsis and septic shock, which have a high mortality rate, especially in critical patients and comorbidities. The diagnosis of CAP generally necessitates an infiltration on Chest X-rays (CXR) in a patient with fever, dyspnea, cough, and sputum.
  • 334
  • 27 Jun 2023
Topic Review
Pancreatic Cancer Molecular Manifestation and Pathways Regulation
Pancreatic cancer is challenging, with a poor progression and limited treatment options. Its tumorigenesis or metastasis involves, pathways, including phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT), RAS, janus kinase (JAK)/signal transducer, and activator of transcription (STAT), NF-κB, Hippo/yes-kinase-associated protein (hippo/YAP), and Wingless/int1 (WNT). These pathways are associated with numerous cellular processes linked to pancreatic cancer, such as apoptosis, angiogenesis, differentiation, immunological regulations, metabolism, migration, and cell proliferation. 
  • 206
  • 27 Jun 2023
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