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Topic Review
Multidetector CT Imaging Biomarkers in Shock
A severe mismatch between the supply and demand of oxygen is the common sequela of all types of shock, which present a mortality of up to 80%. Various organs play a protective role in shock and contribute to whole-body homeostasis. The ever-increasing number of multidetector CT examinations in severely ill and sometimes unstable patients leads to more frequently encountered findings leading to imminent death, together called “hypovolemic shock complex”. Features on CT include dense opacification of the right heart and major systemic veins, venous layering of contrast material and blood, densely opacified parenchyma in the right hepatic lobe, decreased enhancement of the abdominal organ, a dense pulmonary artery, contrast pooling in dependent lungs, and contrast stasis in pulmonary veins. These findings are biomarkers and prognostic indicators of paramount importance which stratify risk and improve patient outcomes.
  • 352
  • 11 Jul 2023
Topic Review
Steroidal (Glyco)Alkaloids: Classification
Steroidal (glycol)alkaloids S(G)As are secondary metabolites made of a nitrogen-containing steroidal skeleton linked to a (poly)saccharide, naturally occurring in the members of the Solanaceae and Liliaceae plant families. The genus Solanum is familiar to all of us as a food source (tomato, potato, eggplant), but a few populations have also made it part of their ethnobotany for their medicinal properties. The recent development of the isolation, purification and analysis techniques have shed light on the structural diversity among the SGAs family, thus attracting scientists to investigate their various pharmacological properties. 
  • 439
  • 11 Jul 2023
Topic Review
The Interaction between Pregnancy and COVID-19
Pregnancy does not increase susceptibility to SARS-CoV-2 infection but appears to worsen the clinical course of COVID-19 (e.g., increased risks of intensive care unit [ICU] admission, need for mechanical ventilation and ventilatory support, and death) compared with non-pregnant females of the same age, especially in those who are symptomatic.  The risk of an exacerbation is greatest in the third trimester. Other risk factors associated with being infected and hospitalised with COVID-19 include Black and Asian minority ethnic backgrounds, living in socioeconomically deprived areas, and working in healthcare or other public-facing occupations
  • 468
  • 11 Jul 2023
Topic Review
Extracellular Vesicles in Amyotrophic Lateral Sclerosis Onset
Amyotrophic lateral sclerosis (ALS) is a severe and incurable neurodegenerative disease characterized by the progressive death of motor neurons, leading to paralysis and death. It is a rare disease characterized by high patient-to-patient heterogeneity, which makes its study arduous and complex. Extracellular vesicles (EVs) have emerged as important players in the development of ALS.
  • 402
  • 11 Jul 2023
Topic Review
The Nervous System in Cancer Hallmarks
The nervous system communicates with the whole organism, regulating several physiological pathways. The modification of nerve activity could deregulate the state of cellular and tissue homeostasis which could drive cancer development.
  • 390
  • 11 Jul 2023
Topic Review
Hypothalamus and the Brainstem in Health and Obesity
The hypothalamus and brainstem are critical components of the homeostatic system that regulates appetite and energy balance. These key brain regions comprise of distinct neuronal populations and nuclei which exerts tremendous control over several facets of energy balance. Importantly, several of these neuronal populations exhibit both overlapping and also contrasting metabolic roles, thereby enabling the CNS to fine tune metabolic functions under physiological conditions.
  • 378
  • 11 Jul 2023
Topic Review
Metabolomic Profiling in Children with Celiac Disease
Celiac disease (CD) is included in the group of complex or multifactorial diseases, i.e., those caused by the interaction of genetic and environmental factors. Despite a growing understanding of the pathophysiological mechanisms of the disease, diagnosis is still often delayed and there are no effective biomarkers for early diagnosis. The only current treatment, a gluten-free diet (GFD), can alleviate symptoms and restore intestinal villi, but its cellular effects remain poorly understood. To gain a comprehensive understanding of CD’s progression, it is crucial to advance knowledge across various scientific disciplines and explore what transpires after disease onset. Metabolomics studies hold particular significance in unravelling the complexities of multifactorial and multisystemic disorders, where environmental factors play a significant role in disease manifestation and progression. 
  • 470
  • 10 Jul 2023
Topic Review
Plant-Based Diets effects on Skin Diseases
A plant-based diet refers to a way of eating that primarily focuses on consuming foods derived from plants. This includes a wide variety of vegetables, fruits, beans, lentils, legumes, nuts, seeds, fungi, and whole grains. Animal products and processed foods are limited or avoided in this dietary approach. Plant-based diets have been found to have benefits for various conditions and diseases and specific plant-based functional foods can play a role in supporting skin health. One of the targets of this dietary pattern is the gut microbiota, the community of microorganisms residing in our digestive system. Improving the health of the gut microbiota may contribute to some of the positive effects observed on overall health, including the skin. By adopting a plant-based diet, individuals can provide their bodies with a rich array of nutrients, antioxidants, and fiber that are abundant in plant foods. These components can support overall health and may have a positive impact on the condition of the skin. However, it's important to note that individual results may vary, and maintaining a balanced diet, as well as considering other factors like skincare routines and overall lifestyle, is essential for optimal skin health.
  • 477
  • 10 Jul 2023
Topic Review
Patient-Derived Cancer Models and Next-Generation Living Biobanks
Biobanks provide a platform for innovative biomedical research. Recent scientific advances in cryopreservation have enabled the prospect of establishing “living biobanks” that store viable, functional tissue or replicable cell types for years to decades.
  • 409
  • 10 Jul 2023
Topic Review
Next-Generation Sequencing in Acute Myeloid Leukemia
Cytological approaches have long been used in the diagnosis, prognosis, and management of acute myeloid leukemia (AML) and myelodysplastic neoplasms. Technological advances in molecular biology, in particular next-generation sequencing (NGS), have made it possible to establish a molecular list of several gene mutations in AML and MDS, within a matter of days.
  • 335
  • 10 Jul 2023
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